The Ages Study: The Reykjavik Study of Healthy Aging for the New Millennium_NIDCD

NIDCD项目描述：AGES-雷克雅未克的研究正在研究遗传易感性和基因/环境相互作用，因为这些因素导致了老年人常见的表型，包括听力损失。NIDCD对听力部分的资助和这项研究的平衡问卷将支持听力检查，包括耳镜检查、声导抗(双侧鼓室导纳测量和同侧声反射)，以及纯音、空气传导测听，以确定每只耳朵在500、1000、2000、3000、4000、6000和8000赫兹的听力阈值。通过与国家老龄研究所(NIA)事先达成的机构内协议，NIDCD资助了2001年至2006年在冰岛雷克雅未克对年龄、基因/环境易感性；雷克雅未克(AGEs/雷克雅未克一世)年龄在67岁至93岁之间的约5 200名受试者的听力检查。随后，由NIA和共同赞助的ICS(NIDCD、NEI和NINDS)资助的AGES，2007？2010年(约3,500名幸存受试者)进行了纵向后续检查。在NIDCD的资助下，提出了关于助听器的使用、听力的主观评估(包括Gallaudet等级)、耳鸣(频率和持续时间)、耳朵疾病和手术以及其他与听力有关的因素的问题。AGES-RS II，2007？2010中也增加了关于研究参与者(从I岁起)或目前经历的具体头晕/平衡和跌倒问题的问题。为了检查广泛的遗传效应，在现有的年龄数据中确定了一级亲属(即兄弟姐妹和亲子组合)。二级亲属或更远的表亲也可以被识别出来。对听力损失遗传学的进一步研究将通过参与广泛的基因组扫描来完成，以寻找与定义的表型的关联，包括根据年龄I的结果定义的年龄相关性听力损失。2012年，对随机选择的较年轻的子代队列(n=500)进行了关于听力状况和平衡/头晕问题的其他后续研究，2013年，将在这个子代样本中增加大约400名年轻的子代受试者，这些受试者根据他们的父母的基因型别和检查结果(表现型)，患阿尔茨海默氏症的风险非常高。这些受试者还将接受听力损失测试，并获得平衡/头晕问卷答复。在整个年龄范围内收集的关于受试者及其后代的其他测量包括大脑成像、详细的视力检查和许多其他评估。可用的协变量包括：年龄、性别、教育程度、中年体重、中年体重变化、吸烟史、体力活动、股四头肌力量和握力(通过等长测力法确定)、合并症情况、过去5年的住院时间、C反应蛋白、空腹血糖和肾小球滤过率(根据体重指数[BMI]进行调整)。

NIDCD Project Description: The AGES-Reykjavik Study is examining genetic susceptibility and gene/environment interaction as these contribute to phenotypes common in old age, including hearing loss. The NIDCD funding of the hearing component and balance questionnaires for this study will support audiometric examinations consisting of otoscopy, acoustic immittance (bilateral tympanometry and ipsilateral acoustic reflexes), and pure-tone, air-conduction audiometry to determine hearing thresholds in each ear at 500, 1000, 2000, 3000, 4000, 6000, and 8000 Hz. Through a prior IntraAgency Agreement with the National Institute on Aging (NIA), NIDCD funded hearing exams on about 5,200 subjects, aged 67 to 93 years in the Age, Gene/Environment Susceptibility; Reykjavik (AGES/Reykjavik I) in Reykjavik, Iceland from 2001 through 2006. Subsequently, AGES¿Reykjavik II, 2007¿2010 (approximately 3,500 surviving subjects), was funded by NIA and co-sponsoring ICs (NIDCD, NEI, and NINDS) to conduct longitudinal follow-up exams. With NIDCD funding, questions have been asked about use of hearing aids, subjective evaluation of hearing acuity including the Gallaudet scale, tinnitus (frequency and duration), ear diseases and operations, and other factors related to hearing. Questions were also added in AGES-RS II, 2007¿2010, regarding specific dizziness/balance and falling problems that study participants had experienced (since AGES I) or currently. In order to examine broad genetic effects, first-degree relatives have been identified in the existing AGES data (i.e., siblings and parent-child combinations). Second-degree relatives or more distant cousins can also be identified. Further investigation of the genetics of hearing loss will be accomplished through participation in a broad genome scan for associations with defined phenotypes, including age-related hearing loss defined on the basis of results in AGES I. Additional follow-up studies of hearing status and balance/dizziness questions were performed in 2012 on a younger, randomly-selected AGES offspring cohort (n=500) and, in 2013, this offspring sample will be augmented with approximately 400 younger offspring subjects who, based on their parents¿ genotypes and exam results (phenotypes) are at very high risk of developing Alzheimer¿s. These subjects will also be tested for hearing loss and balance/dizziness questionnaire responses will be obtained. Other measures collected throughout on AGES subjects and their offspring include brain imaging, detailed vision exams, and many other assessments. Available covariates include: age, gender, education, weight at midlife, weight change from midlife, smoking history, physical activity, quadriceps strength and hand grip strength (determined by Isometric dynamometry), co-morbid conditions, hospitalization in previous 5 years, CRP, fasting glucose, and glomerular filtration rate or GFR (adjusted for body mass index [BMI]).