The Ages Study: The Reykjavik Study of Healthy Aging for the New Millennium_NIDCD

年龄研究：雷克雅未克新千年健康老龄化研究_NIDCD

• 批准号: 8733934
• 负责人: VILMUNDUR GUDNASON
• 金额: $ 15万
• 依托单位: ICELANDIC HEART ASSOCIATION
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8733934
• 关键词: Acoustics; Age; Agreement; Air; Alzheimer' s Disease; Audiometry; Bilateral; Body Weight Changes; Body mass index; Brain imaging; Child; Collaborations; Confidentiality; Data; Data Collection; Distant; Dizziness; Documentation; Ear; Ear Diseases; Education; Environment; Epidemiology; Equilibrium; Evaluation; First Degree Relative; Frequencies; Funding; Gender; Genetic; Genetic Predisposition to Disease; Genome Scan; Genotype; Glomerular Filtration Rate; Hand Strength; Hearing; Hearing Aids; Hospitalization; Human Resources; Iceland; Interview; Investigation; Ipsilateral; Isometric Exercise; Knowledge; Lightheadedness; Measures; National Institute of Neurological Disorders and Stroke; National Institute on Aging; National Institute on Deafness and Other Communication Disorders; Otoscopy; Parents; Participant; Phenotype; Physical activity; Policies; Predisposition; Presbycusis; Presyncopes; Prevention; Privacy; Protocols documentation; Publications; Questionnaires; Reporting; Sampling; Second Degree Relative; Siblings; Smoking History; Susceptibility Gene; Symptoms; Syncope; Testing; Tinnitus; Training; Tympanometry; United States National Institutes of Health; Vertigo; Vision; Weight; Work; acoustic reflex; aged; aging gene; base; cohort; experience; falls; fasting glucose; follow-up; gene environment interaction; grasp; healthy aging; hearing impairment; high risk; meetings; middle age; offspring; operation; quadriceps muscle; response; visual image movement

NIDCD Project Description: The AGES-Reykjavik Study is examining genetic susceptibility and gene/environment interaction as these contribute to phenotypes common in old age, including hearing loss. The NIDCD funding of the hearing component and balance questionnaires for this study will support audiometric examinations consisting of otoscopy, acoustic immittance (bilateral tympanometry and ipsilateral acoustic reflexes), and pure-tone, air-conduction audiometry to determine hearing thresholds in each ear at 500, 1000, 2000, 3000, 4000, 6000, and 8000 Hz. Through a prior IntraAgency Agreement with the National Institute on Aging (NIA), NIDCD funded hearing exams on about 5,200 subjects, aged 67 to 93 years in the Age, Gene/Environment Susceptibility; Reykjavik (AGES/Reykjavik I) in Reykjavik, Iceland from 2001 through 2006. Subsequently, AGES¿Reykjavik II, 2007¿2010 (approximately 3,500 surviving subjects), was funded by NIA and co-sponsoring ICs (NIDCD, NEI, and NINDS) to conduct longitudinal follow-up exams. With NIDCD funding, questions have been asked about use of hearing aids, subjective evaluation of hearing acuity including the Gallaudet scale, tinnitus (frequency and duration), ear diseases and operations, and other factors related to hearing. Questions were also added in AGES-RS II, 2007¿2010, regarding specific dizziness/balance and falling problems that study participants had experienced (since AGES I) or currently. In order to examine broad genetic effects, first-degree relatives have been identified in the existing AGES data (i.e., siblings and parent-child combinations). Second-degree relatives or more distant cousins can also be identified. Further investigation of the genetics of hearing loss will be accomplished through participation in a broad genome scan for associations with defined phenotypes, including age-related hearing loss defined on the basis of results in AGES I. Additional follow-up studies of hearing status and balance/dizziness questions were performed in 2012 on a younger, randomly-selected AGES offspring cohort (n=500) and, in 2013, this offspring sample will be augmented with approximately 400 younger offspring subjects who, based on their parents¿ genotypes and exam results (phenotypes) are at very high risk of developing Alzheimer¿s. These subjects will also be tested for hearing loss and balance/dizziness questionnaire responses will be obtained. Other measures collected throughout on AGES subjects and their offspring include brain imaging, detailed vision exams, and many other assessments. Available covariates include: age, gender, education, weight at midlife, weight change from midlife, smoking history, physical activity, quadriceps strength and hand grip strength (determined by Isometric dynamometry), co-morbid conditions, hospitalization in previous 5 years, CRP, fasting glucose, and glomerular filtration rate or GFR (adjusted for body mass index [BMI]).

NIDCD项目描述：AGES-Reykjavik研究正在研究遗传易感性和基因/环境相互作用，因为这些因素有助于老年人常见的表型，包括听力损失。NIDCD资助本研究的听力组成部分和平衡问卷将支持听力检查，包括耳镜检查、声导抗（双侧鼓室导抗和同侧声反射）和纯音气导测听，以确定每只耳朵在500、1000、2000、3000、4000、6000和8000 Hz下的听力阈值。2001年至2006年，通过与国家老龄问题研究所签订的机构内协议，国家残疾人和发展研究所资助了在冰岛雷克雅未克进行的年龄、基因/环境易感性（雷克雅未克第一次老龄问题研究所）听力检查，对象为约5 200名年龄在67至93岁之间的受试者。随后，年龄雷克雅未克II，2007年至2010年（约3，500名存活受试者）由NIA和共同赞助的IC（NIDCD、NEI和NINDS）资助进行纵向随访检查。在NIDCD的资助下，询问了有关助听器的使用、包括Gallaudet量表在内的听力敏锐度主观评估、耳鸣（频率和持续时间）、耳部疾病和手术以及与听力有关的其他因素的问题。在AGES-RS II，2007 <$2010中还增加了关于研究参与者经历过（自AGES I以来）或目前存在的特定头晕/平衡和跌倒问题的问题。为了研究广泛的遗传效应，在现有的AGES数据中已经确定了一级亲属（即，兄弟姐妹和父子组合）。二级亲属或更远的堂兄弟也可以被识别。将通过参与广泛的基因组扫描来完成对听力损失遗传学的进一步研究，以确定与定义的表型的关联，包括根据AGES I结果定义的年龄相关听力损失。2012年，对一个随机选择的年轻AGES后代队列（n=500）进行了听力状态和平衡/头晕问题的额外随访研究，2013年，该后代样本将增加约400名年轻后代受试者，这些受试者根据其父母的基因型和检查结果（表型），患阿尔茨海默病的风险非常高。还将对这些受试者进行听力损失测试，并将获得平衡/头晕问卷回答。对AGES受试者及其后代收集的其他措施包括大脑成像，详细的视力检查和许多其他评估。可用的协变量包括：年龄、性别、教育、中年体重、中年体重变化、吸烟史、体力活动、股四头肌力量和握力（通过等轴测力法测定）、共病情况、过去5年的住院情况、CRP、空腹血糖和肾小球滤过率或GFR（根据体重指数[BMI]校正）。