Real-time Diffuse near-IR Optical Tomography with EEG Recordings

带脑电图记录的实时漫反射近红外光学断层扫描

基本信息

  • 批准号:
    7480254
  • 负责人:
  • 金额:
    $ 3.32万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-07-15 至 2011-07-14
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Recent developments in imaging (i.e. functional MRI) have endowed researchers with the ability to visualize brain activity in real time. However, many of these imaging techniques 1) are expensive and timeconsuming to use; 2) do not allow subjects to fully interact with their environment; and 3) do not allow for truly simultaneous electrical measurements. Dynamic Near-infrared Optical Tomography (DYNOT) is a new non-invasive imaging technology that allows the researcher to explore hemodynamic changes in the brain in real time. Hb changes can be correlated to brain activity using current theories on the physiologic requirements for brain function, similar to the Blood-Oxygen Level Dependent (BOLD) response obtained with fMRI. The technology is economical, can be made portable, and allows for combination with other physiological monitoring technologies, namely EEC and associated single-cell electrical recordings. This project aims to combine the latest version of DYNOT technology, functional imaging in freely moving animals, with multi and intra-cellular neural recordings of various brain regions, in rats undergoing pre-established learning tasks that elicit a specific response in one of three brain regions. Both DYNOT & EEC/single cell recordings can be simultaneously measured from probes/electrodes attached to the animal's head, allowing for study of the switching among memory systems as tasks are performed. Furthermore, the experimental setup is well suited for an emerging signal processing methodology in neuroscience, called synchrony index, which is capable of measuring the phase-locking between a set of intracellular recordings within the hippocampus. Synchrony index calculations on sets of EEG/intracellular recordings from the three brain regions to be studied will allow us to demonstrate communication between the neurons in these regions. The combined recordings with synchrony index calculations will permit the study of learning and memory storage, as well as interconnections between a variety of brain regions in real time, all while the subject is free to interact with all aspects of the environment. Successful demonstration of this integrated approach will set the stage for the exploration of a spectrum of other normal brain functions and pathologies involving real-world stimuli, learning, and memory storage/recall. In the future, this work can have applications in the study of ADHD, epilepsy, Alzheimer's Disease, stroke, brain edema, and meningeal hemorrhages.
描述(由申请人提供): 最近的发展,在成像(即功能磁共振成像)赋予研究人员的能力,以可视化的大脑活动在真实的时间。然而,这些成像技术中的许多1)使用起来昂贵且耗时; 2)不允许受试者与其环境充分交互;以及3)不允许真正同时的电测量。动态近红外光学断层成像(DYNOT)是一种新的无创成像技术,它可以使研究者真实的实时地探索脑血流动力学的变化。血红蛋白的变化可以与脑活动使用目前的理论对脑功能的生理要求,类似于血氧水平依赖(BOLD)的反应得到的功能磁共振成像。该技术是经济的,可以制成便携式,并允许与其他生理监测技术,即EEC和相关的单细胞电记录相结合。该项目旨在将最新版本的DYNOT技术联合收割机,自由移动动物的功能成像,与不同脑区的多细胞和细胞内神经记录相结合,在大鼠中进行预先建立的学习任务,在三个脑区之一引起特定反应。DYNOT和EEC/单细胞记录可以同时从连接到动物头部的探针/电极进行测量,从而可以研究任务执行时记忆系统之间的切换。此外,该实验装置非常适合神经科学中新兴的信号处理方法,称为同步指数,其能够测量海马内一组细胞内记录之间的锁相。同步指数计算的EEG/细胞内记录从三个大脑区域进行研究,将使我们能够证明在这些地区的神经元之间的通信。结合同步指数计算的记录将允许学习和记忆存储的研究,以及在真实的时间内各种大脑区域之间的互连,同时受试者可以自由地与环境的各个方面进行交互。这种综合方法的成功演示将为探索其他正常大脑功能和病理的光谱奠定基础,这些功能和病理涉及现实世界的刺激,学习和记忆存储/回忆。将来,这项工作可以应用于ADHD,癫痫,阿尔茨海默病,中风,脑水肿和脑膜炎的研究。

项目成果

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Mark Farber其他文献

Mark Farber的其他文献

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{{ truncateString('Mark Farber', 18)}}的其他基金

Real-time Diffuse near-IR Optical Tomography with EEG Recordings
带脑电图记录的实时漫反射近红外光学断层扫描
  • 批准号:
    7644839
  • 财政年份:
    2007
  • 资助金额:
    $ 3.32万
  • 项目类别:
Real-time Diffuse near-IR Optical Tomography with EEG Recordings
带脑电图记录的实时漫反射近红外光学断层扫描
  • 批准号:
    7333545
  • 财政年份:
    2007
  • 资助金额:
    $ 3.32万
  • 项目类别:

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