Functional Relevance of Spontaneous BOLD Fluctuations

这项研究的目的是了解目前人类大脑的内在持续功能 即使在没有任务或刺激的情况下。具体而言，目前的研究将表征功能性 fMRI BOLD信号的内在或自发波动的相关性。这些自发的影响 波动对任务相关的BOLD反应以及自发波动的影响， 行为将被检查。确定神经元自发波动之间的关系 活动，神经元对刺激的反应，以及由此产生的行为对于理解 大脑的运作。此外，自发BOLD波动的功能相关性对于 了解不同病理条件下这些波动的干扰。

The objective of this research is to understand the intrinsic ongoing functionality of the human brain present even in the absence of tasks or stimuli. Specifically, the current study will characterize the functional relevance of intrinsic or spontaneous fluctuations in the fMRI BOLD signal. The effect of these spontaneous fluctuations on task-related BOLD responses as well as the influence of spontaneous fluctuations on behavior will be examined. Determining the relationship between spontaneous fluctuations in neural activity, the neuronal response to a stimulus, and the resulting behavior is critical to understanding the operation of the brain. Further, the functional relevance of spontaneous BOLD fluctuations is important for understanding reported disturbances in these fluctuations in different pathological conditions.