Selective screening for osteoporosis in younger postmenopausal women

年轻绝经后女性骨质疏松症的选择性筛查

• 批准号: 7467908
• 负责人: MARGARET L GOURLAY
• 金额: $ 13.24万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-11 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7467908
• 关键词: Advanced Development; Advisory Committees; Age; Aging; Award; Bone Density; Classification; Clinic; Clinical Research; Cohort Studies; Communities; Condition; Data; Data Analyses; Databases; Decision Making; Development; Development Plans; Diagnosis; Elderly; Eligibility Determination; Environment; Family Practice; Feasibility Studies; Forearm; Fracture; Funding; Goals; Indium; Lead; Leadership; Learning; Measures; Mentors; Mentorship; Methodology; Methods; Morbidity - disease rate; North Carolina; Osteoporosis; Outcome; Patients; Pattern; Peripheral; Pilot Projects; Population; Population Study; Postmenopause; Predictive Value; Preventive; Primary Health Care; Principal Investigator; Probability; Protocols documentation; Range; Recruitment Activity; Research; Research Design; Research Methodology; Research Personnel; Research Project Grants; Risk; Risk Assessment; Score; Screening procedure; Self Assessment; Services; Specialist; Techniques; Testing; Therapeutic; Universities; Vertebral column; Woman; aged; base; calcaneum; career; concept; cost; diagnostic accuracy; hip bone; indexing; instrument; mortality; older women; osteoporosis with pathological fracture; prevent; professor; programs; skills; tool

DESCRIPTION (provided by applicant): Candidate: Margaret Gourlay, MD, MPH is an assistant professor of Family Medicine at the University of North Carolina. Career Development Plan: the candidate will participate in coursework and mentored research to learn essential skills in osteoporosis study design and implementation and to develop academic leadership. Immediate Objective: to acquire expertise in epidemiologic and densitometric concepts in osteoporosis screening research. Long-term Objective: to decrease fracture-related morbidity and mortality in the elderly by advancing the development of an evidence-based osteoporosis screening protocol for postmenopausal women under age 65 in primary care practices. Specific Aims: 1) determine if two existing methods of fracture risk assessment are accurate in younger postmenopausal women, 2) determine if existing osteoporosis risk assessment tools are accurate in younger postmenopausal women, and 3) test the feasibility of a study of selective screening to identify osteoporosis in younger postmenopausal women. Research Methods: in aims 1 and 2, secondary analyses of data from the two largest US osteoporosis cohort studies (NORA, SOF) will compare the ability of a fracture index vs. peripheral bone density to predict fracture in postmenopausal women aged 50 to 64, and will compare the ability of osteoporosis risk tools to identify peripheral osteoporosis in younger vs. older postmenopausal women. In aim 3, a feasibility study that includes central and peripheral bone density measures will provide preliminary data for an R01 study of selective osteoporosis screening in younger postmenopausal women. Environment: patients will be recruited from 3 UNC primary care clinics and community family medicine clinics for the aim 3 feasibility study conducted in the NIH-funded General Clinical Research Center at UNC. Mentorship: mentorship will be provided by two highly successful NIA-funded researchers on aging (Drs. Sloane and Zimmerman), a national expert on screening methodology (Dr. Ransohoff), osteoporosis specialists (Drs. Rubin and Ontjes), and a biostatistical expert (Dr. Preisser). Investigators from NORA (Dr. Miller) and SOF (Dr. Ensrud) will supervise the analyses in aims 1 and 2. Relevance: osteoporosis is a common, preventable condition that leads to high fracture-related morbidity and mortality in postmenopausal women. This study will test osteoporosis screening strategies for postmenopausal women under 65 with the goal of preventing fracture.

描述（由申请人提供）：候选人：玛格丽特Gourlay，医学博士，公共卫生硕士是家庭医学助理教授在北卡罗来纳州的大学。职业发展计划：候选人将参加课程和指导研究，学习骨质疏松症研究设计和实施的基本技能，并发展学术领导能力。近期目标：获得骨质疏松症筛查研究中流行病学和密度测量概念的专业知识。长期目标：通过在初级保健实践中推进65岁以下绝经后妇女的循证骨质疏松症筛查方案的制定，降低老年人与骨质疏松症相关的发病率和死亡率。具体目标：1）确定两种现有的骨折风险评估方法在年轻绝经后妇女中是否准确，2）确定现有的骨质疏松风险评估工具在年轻绝经后妇女中是否准确，3）测试选择性筛查研究的可行性，以确定年轻绝经后妇女的骨质疏松症。研究方法：在目标1和2中，对来自两项最大的美国骨质疏松症队列研究（诺拉，SOF）的数据进行二次分析，将比较骨折指数与外周骨密度预测50 - 64岁绝经后妇女骨折的能力，并将比较骨质疏松症风险工具识别年轻与老年绝经后妇女外周骨质疏松症的能力。在目标3中，一项包括中心和外周骨密度测量的可行性研究将为在年轻绝经后妇女中进行选择性骨质疏松症筛查的R 01研究提供初步数据。工作环境：将从3个初级保健诊所和社区家庭医学诊所招募患者，用于在NIH资助的通用临床研究中心进行的aim 3可行性研究。导师制：两名非常成功的由国家老龄化研究所资助的老龄化研究人员（Sloane博士和齐默尔曼博士）、一名国家筛查方法专家（Ransohoff博士）、骨质疏松症专家（Rubin博士和Ontjes博士）和一名生物统计专家（Preisser博士）将提供指导。来自诺拉（米勒博士）和SOF（Ensrud博士）的研究者将监督目标1和2中的分析。相关性：骨质疏松症是一种常见的，可预防的疾病，导致绝经后妇女的高绝经相关的发病率和死亡率。这项研究将测试65岁以下绝经后妇女的骨质疏松症筛查策略，目的是预防骨折。