Sleep Fragmentation and Attention in Alzheimer's Disease

描述（由申请人提供）：这个提议的3年职业发展奖项的总体目标是（PWAD）。具体来说，我将1)在PWAD中使用和解释客观睡眠和认知测量方面接受高级培训，2)获得睡眠机制和AD认知表现的详细知识，3)获得建立旨在理解急性和慢性睡眠碎片化机制及其对PWAD影响的研究项目所需的技能。除了课程作业、指导学习和参加专业会议之外。我建议首先调查1晚睡眠中断和1晚不受干扰的恢复性睡眠对PWAD患者注意力的影响。虽然有初步的证据表明，睡眠碎片会影响没有认知障碍的人的注意力，但还没有人对重度睡眠障碍患者进行研究。阿尔茨海默病主要被认为是一种记忆受损的疾病，尽管注意力和记忆不一样，但注意力的能力是记忆的先决条件，无法集中注意力可能会导致或加重记忆问题。我是一名高级执业护士，在我的实践中，我照顾过老年人，其中许多人患有痴呆症。在阿肯色大学医学科学博士后研究与博士。凯西·理查兹和科妮莉亚·贝克在睡眠研究领域开辟了一条新的职业道路，这条道路有可能增加对睡眠碎片化对PWAD患者认知的短期和长期影响的理解，并有希望针对干预措施减缓他们的记忆衰退。但我是这个领域的新手，需要职业发展奖提供的额外时间来继续发展专业知识。由于我们对这个项目的共同承诺，我已经努力制定了一项建议，将补充而不是重复博士。理查兹和贝克的作品。

DESCRIPTION (provided by applicant): The overarching goal of this proposed 3 year career development award is (PWAD). Specifically, I will 1) pursue advanced training in the use and interpretation of objective measurements of sleep and cognition in PWAD, 2) gain detailed knowledge of mechanisms underlying sleep and the cognitive manifestations of AD, and 3) acquire the skills needed to build a program of research aimed at understanding the mechanisms of acute and chronically fragmented sleep and its effect on PWAD. In addition to coursework, guided studies, and attendance at professional meetings. I propose to begin by investigating the effect of 1 night of sleep fragmentation and 1 night of undisturbed recovery sleep on attention in PWAD. Although there is beginning evidence that sleep fragmentation affects attention in persons without cognitive impairment, no one has studied it in PWAD. Alzheimer's disease is primarily thought of as a disease of impaired memory and although attention is not the same as memory, the ability to pay attention is a prerequisite for memory and the inability to pay attention may cause or worsen memory complaints. I am an advanced practice nurse and in my practice I have cared for older adults, many of whom had dementia. Postdoctoral study at the University of Arkansas for Medical Sciences with Drs. Kathy Richards and Cornelia Beck has opened a new career path in the area of sleep research in PWAD that has the potential to increase understanding of the short-term and long-term effects of sleep fragmentation on cognition in PWAD and hopefully, to target interventions that will slow their memory decline. But I am a novice in this field and need the additional time a career development award provides to continue to develop expertise. Since our mutual commitment to this project I have worked to develop a proposal that will complement and not duplicate Drs. Richards and Beck's work.