Sleep Fragmentation and Attention in Alzheimer's Disease

阿尔茨海默病的睡眠碎片化和注意力

• 批准号: 7144853
• 负责人: CATHERINE Sue COLE
• 金额: $ 9.55万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7144853
• 关键词: Alzheimer' s disease; REM sleep; attention; behavioral /social science research tag; clinical research; cognition; human subject; pathologic process; patient oriented research; polysomnography; psychic activity level; sleep deprivation; wakefulness

DESCRIPTION (provided by applicant): The overarching goal of this proposed 3 year career development award is (PWAD). Specifically, I will 1) pursue advanced training in the use and interpretation of objective measurements of sleep and cognition in PWAD, 2) gain detailed knowledge of mechanisms underlying sleep and the cognitive manifestations of AD, and 3) acquire the skills needed to build a program of research aimed at understanding the mechanisms of acute and chronically fragmented sleep and its effect on PWAD. In addition to coursework, guided studies, and attendance at professional meetings. I propose to begin by investigating the effect of 1 night of sleep fragmentation and 1 night of undisturbed recovery sleep on attention in PWAD. Although there is beginning evidence that sleep fragmentation affects attention in persons without cognitive impairment, no one has studied it in PWAD. Alzheimer's disease is primarily thought of as a disease of impaired memory and although attention is not the same as memory, the ability to pay attention is a prerequisite for memory and the inability to pay attention may cause or worsen memory complaints. I am an advanced practice nurse and in my practice I have cared for older adults, many of whom had dementia. Postdoctoral study at the University of Arkansas for Medical Sciences with Drs. Kathy Richards and Cornelia Beck has opened a new career path in the area of sleep research in PWAD that has the potential to increase understanding of the short-term and long-term effects of sleep fragmentation on cognition in PWAD and hopefully, to target interventions that will slow their memory decline. But I am a novice in this field and need the additional time a career development award provides to continue to develop expertise. Since our mutual commitment to this project I have worked to develop a proposal that will complement and not duplicate Drs. Richards and Beck's work.

描述(由申请者提供)：这个拟议的3年职业发展奖的首要目标是(PWAD)。具体地说，我将1)在PWAD中使用和解释客观的睡眠和认知测量方法进行高级培训，2)详细了解潜在的睡眠机制和AD的认知表现，3)获得必要的技能，以建立一个研究计划，旨在了解急性和慢性零碎睡眠的机制及其对PWAD的影响。除了课程作业、指导学习和参加专业会议之外。我建议首先调查1晚零碎睡眠和1晚不受干扰的恢复睡眠对PWAD患者注意力的影响。尽管有初步证据表明，睡眠碎片会影响没有认知障碍的人的注意力，但还没有人在PWAD中对其进行研究。阿尔茨海默病最初被认为是一种记忆受损的疾病，尽管注意力与记忆不同，但注意力的能力是记忆的先决条件，注意力不集中可能会导致或恶化记忆问题。我是一名高级实习护士，在我的实习中我照顾过老年人，其中许多人患有痴呆症。在阿肯色医学大学与Kathy Richards博士和Cornelia Beck博士进行的博士后研究为PWAD的睡眠研究领域开辟了一条新的职业道路，有可能增加对睡眠碎片对PWAD认知的短期和长期影响的了解，并有望针对将减缓他们记忆衰退的干预措施。但我是这个领域的新手，需要职业发展奖提供的额外时间来继续发展专业知识。自从我们共同致力于这个项目以来，我一直在努力制定一项提案，该提案将补充而不是重复理查兹和贝克博士的工作。