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Psychotherapy for Depressed Primary Care Patients

抑郁初级保健患者的心理治疗

基本信息

批准号：
7319640
负责人：
Lisa A Uebelacker
金额：
$ 18.11万
依托单位：
BUTLER HOSPITAL (PROVIDENCE, RI)
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-12-01 至 2010-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7319640
关键词：
Adherence Antidepressive Agents Attention Award Characteristics Clinical Clinical Research Clinical Trials Competence Data Depressed mood Disease remission Educational process of instructing Family Family member Feedback Goals Grant Individual Intervention Knowledge Learning Literature Love Major Depressive Disorder Manuals Manuscripts Measures Medical Mental Depression Mentored Patient-Oriented Research Career Development Award Mentorship Outcome Outcome Measure Patients Pharmaceutical Preparations Pharmacological Treatment Pharmacotherapy Population Preparation Price Primary Care Physician Primary Health Care Problem Solving Procedures Process Provider Psychiatrist Psychotherapy Randomized Controlled Clinical Trials Randomized Controlled Trials Range Research Research Ethics Research Personnel Research Project Grants Resources Staging Symptoms Testing Training Week Woman Work Writing base career collaborative care depressive symptoms design experience improved medical schools medication compliance men problem solving therapy programs psychoeducation psychopharmacologic psychosocial satisfaction single episode major depressive disorder size skills treatment effect treatment trial trial comparing

项目摘要

DESCRIPTION (provided by candidate): This application is a resubmission of a request for a Mentored Patient-Oriented Research Career Development Award (K23) that will enable Dr. Uebelacker to develop her career as a clinical researcher with a programmatic line of research on treatments for depression that are accessible to a wide range of individuals and families. In particular, she will focus on the primary care setting. Primary care providers treat many individuals with major depressive disorder, usually with an antidepressant. However, at least half of these individuals do not respond fully to this treatment strategy. Thus, Dr. Uebelacker's initial goal is to develop an integrated problem-solving therapy for patients and families (IPST-PF) to augment "usual treatment" for primary care patients with persistent depression despite initial pharmacotherapy. Dr. Uebelacker's training goals are: 1) to develop expertise in clinical research in primary care settings; 2) to develop expertise in the design, execution, and analysis of clinical trials; 3) to improve knowledge of research ethics; 4) to develop increased competence in clinical work and research with multicultural populations; 5) to understand clinical and research issues in the use of psychotropic medications; and 6) to improve grant-writing and manuscript preparation skills. This training will be accomplished through 1) resources at Brown Medical School; 2) mentorship from Drs. Ivan Miller, Charles Eaton, and Lawrence Price, and consultants Drs. Wayne Katon and Debra Lobato; 3) coursework, seminars, and supervised clinical experiences; and 4) implementation of the proposed project. Dr. Uebelacker will implement a 5-year research project, during which she will develop and test IPST-PF for primary care patients with persistent depression. IPST-PF will be based on problem-solving therapy, and will include psychoeducation, problem-solving, and a focus on medication adherence. Family members will attend some therapy sessions. IPST-PF will augment treatment-as-usual. The first 18 months of the proposed award will be devoted to developing IPST-PF and piloting it in an open trial. Subsequently, Dr. Uebelacker will conduct a small randomized trial, comparing IPST-PF plus treatment-as-usual to treatment-as-usual. These data will be used to estimate an effect size, which in turn will be used to justify an R01 application for a full-scale clinical trial.

描述（由候选人提供）：此应用程序是一个指导的以患者为导向的研究职业发展奖（K23）的请求重新提交，这将使Uebelacker博士发展她的职业生涯作为一个临床研究人员与抑郁症的治疗，可访问范围广泛的个人和家庭的研究方案线。特别是，她将专注于初级保健环境。初级保健提供者治疗许多患有重度抑郁症的人，通常使用抗抑郁药。然而，这些人中至少有一半对这种治疗策略没有完全反应。因此，Uebelacker博士的最初目标是为患者和家庭开发一种综合解决问题的治疗方法（IPST-PF），以加强对持续抑郁的初级保健患者的“常规治疗”，尽管最初的药物治疗。博士Uebelacker的培训目标是：1）在初级保健环境中发展临床研究的专业知识; 2）发展临床试验设计，执行和分析的专业知识; 3）提高研究伦理知识; 4）发展临床工作和研究的能力与多元文化人群; 5）了解精神药物使用中的临床和研究问题;（6）提高基金撰写和论文准备技能。该培训将通过以下方式完成：1）布朗医学院的资源; 2）来自Ivan米勒、Charles Eaton和Lawrence Price博士以及顾问韦恩Katon和Debra Lobato博士的指导; 3）课程、研讨会和监督临床经验;以及4）实施拟议项目。 Uebelacker博士将实施一项为期5年的研究项目，在此期间，她将开发和测试IPST-PF用于持续性抑郁症的初级保健患者。IPST-PF将基于解决问题的治疗，并将包括心理教育，解决问题，并专注于药物依从性。家庭成员将参加一些治疗会议。IPST-PF将增加常规治疗。该奖项的前18个月将致力于开发IPST-PF并在公开试验中进行试点。随后，Uebelacker博士将进行一项小型随机试验，比较IPST-PF加常规治疗与常规治疗。这些数据将用于估计效应量，进而用于证明R 01申请用于全面临床试验的合理性。