Enhancing new developments in ToF-SIMS through researcher exchanges
通过研究人员交流促进 ToF-SIMS 的新发展
基本信息
- 批准号:EP/F012985/1
- 负责人:
- 金额:$ 13.99万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2007
- 资助国家:英国
- 起止时间:2007 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We are involved in a programme of a research that is advancing the capability of the technique - Time of Flight Secondary Ion Mass Spectrometry - ToF-SIMS. which, by bombarding the surface with moderate energy particles, analyses the surface chemistry of materials by removing and analysing molecular and atomic fragments in the form of charged particles (or ions). The research has two directions. First we are capitalising on our exciting advances using bucky-ball (C60) and metal cluster beams to bombard the surface. C60 beams in particular remove molecules rather gently (ensuring that they are much less damaged in the removal process than under atomic beam bombardment), but in large quantities, enhancing sensitivity and analytical efficiency. Our research in collaboration with Prof Webbs' group in the University of Surrey is seeking to understand how these beams remove molecules from the surface, so that we can tailor their use to the samples to be analysed. This fundamental research is accompanied by some adventurous instrumental developments in collaboration with two small high technology UK companies - Ionoptika Ltd and SIA Ltd. We are developing a totally new instrument that exploits the capability of the C60 beam and uniquely combines ToF-SIMS and the complementary infra-red spectroscopy ATR-IR technique.We believe that the success of this project will be greatly enhanced by developing some closer collaborations via exchange visits with a number of international experts in their fields. Four areas will be developed: 1. To optimise the operation of the polyatomic ion beam: By reversing the operation of a computer model, developed by Prof Garrison of Penn State University, that describes the way the cluster beam hits the surface to remove molecules, so that it tells us what the cluster beam should be like to remove the molecules we want in large quantities. This has not been done before, but it would greatly help the experimentalists to rapidly chose the right conditions for the ion beam to get the data they need. Prof Garrison will visit Manchester and Surrey for 4 months and Prof Webb will visit Penn State to bring these ideas to fruition.2. To Enhance ionisation: Mass Spectrometry can only detect ions, but the proportion of species emitted as ions is less than 0.01%. It is obvious that if this could be increased the sensitivity would be dramatically enhanced. In a 4 month visit to Manchester Prof Winograd will seek to develop his ideas on new ways of getting the molecules to pick up protons, changing them into detectable positive ions as they leave the surface.3. To enhance the efficiency of data processing software: The new instrument we are developing with Ionoptika and SAI Ltd will turn out a very large amount of information much faster than any current instrument. The computer that processes this information needs to do it very efficiently. A world expert in developing the software to proceess large amounts of data very quickly in an understandable manner, Prof Reichenbach from Nebraska will spend three months in Manchester to collaborate with our own software engineer, Dr Henderson and those of SAI and Ionoptika to begin to develop a software package that will meet our needs. Dr Henderson will go to the US to develop the work further.3. Prof Heeren's group in Amsterdam have developed an instrument of rather different design aimed at doing a similar job to the one we are building. We propose to map out the ways in which the designs complement each other using our C60 ion beam system. We will lend the Amsterdam group one of our C60 ion beams, then exchange researchers and carry out a similar set of experiments on each system. Based on the results of this series of experiments we will map out the complementary capabilities of the two instruments and develop a long-term collaboration in the area of analytical and imaging mass spectrometry of biological systems.
我们参与了一项研究计划,该计划正在推进该技术的能力-飞行时间二次离子质谱- ToF-SIMS。它通过用中等能量粒子轰击表面,通过去除和分析带电粒子(或离子)形式的分子和原子碎片来分析材料的表面化学。研究有两个方向。首先,我们正在利用我们令人兴奋的进步,使用巴基球(C60)和金属簇束轰击表面。特别是C60束可以相当温和地去除分子(确保它们在去除过程中比原子束轰击下受到的损害要小得多),但数量很大,提高了灵敏度和分析效率。我们与萨里大学Webbs教授小组合作的研究正在寻求了解这些光束如何从表面去除分子,以便我们可以根据待分析的样本量身定制它们的用途。这项基础研究伴随着与两家小型高科技英国公司- Ionoptika Ltd和SIA Ltd合作的一些冒险的仪器开发。我们正在开发一种全新的仪器,该仪器利用C60光束的能力,并独特地结合了ToF-SIMS和互补的红外光谱ATR-红外技术。我们相信,通过与一些国际专家在各自领域的互访,发展一些更密切的合作,将大大提高该项目的成功。将开发四个领域:1。优化多原子离子束的操作:通过反转由宾夕法尼亚州立大学的Garrison教授开发的计算机模型的操作,该模型描述了簇束撞击表面以去除分子的方式,因此它告诉我们簇束应该是什么样的,以大量去除我们想要的分子。这是以前没有做过的,但它将极大地帮助实验人员快速选择离子束的正确条件,以获得他们需要的数据。加里森教授将访问曼彻斯特和萨里4个月,韦伯教授将访问宾夕法尼亚州立大学,使这些想法的成果。增强电离:质谱法只能检测离子,但以离子形式发射的物质比例小于0.01%。很明显,如果能够增加这一点,灵敏度将大大提高。在对曼彻斯特为期4个月的访问中,Winograd教授将寻求发展他的想法,即让分子拾取质子的新方法,当它们离开表面时,将它们变成可检测的正离子。为了提高数据处理软件的效率:我们与Ionoptika和SAI Ltd合作开发的新仪器将比任何现有仪器更快地产生大量信息。处理这些信息的计算机需要非常高效地完成。来自内布拉斯加州的赖兴巴赫教授是一位世界级的软件开发专家,他将在曼彻斯特逗留三个月,与我们自己的软件工程师亨德森博士以及SAI和Ionoptika的软件工程师合作,开始开发一个满足我们需求的软件包。亨德森博士将去美国进一步发展这项工作。海伦教授在阿姆斯特丹的研究小组开发了一种设计截然不同的仪器,目的是完成与我们正在建造的仪器类似的工作。我们建议使用我们的C60离子束系统来绘制这些设计相互补充的方式。我们将把我们的一个C60离子束借给阿姆斯特丹小组,然后交换研究人员,在每个系统上进行一系列类似的实验。根据这一系列实验的结果,我们将绘制出两种仪器的互补能力,并在生物系统的分析和成像质谱领域开展长期合作。
项目成果
期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The effect of the H:C ratio on the sputtering of molecular solids by fullerenes
H:C比对富勒烯分子固体溅射的影响
- DOI:10.1002/sia.3421
- 发表时间:2011
- 期刊:
- 影响因子:1.7
- 作者:Webb R
- 通讯作者:Webb R
A molecular dynamics study of a 5 keV C 60 fullerene impact on a two-component organic molecular sample
5 keV C 60 富勒烯对双组分有机分子样品影响的分子动力学研究
- DOI:10.1002/sia.3527
- 发表时间:2011
- 期刊:
- 影响因子:1.7
- 作者:Ponomarev M
- 通讯作者:Ponomarev M
New System for Efficient and Rapid Encoding of Mass Spectral Data for Interactive Visualization of 2D and 3D Hyperspectral Images
用于高效快速编码质谱数据以实现 2D 和 3D 高光谱图像交互式可视化的新系统
- DOI:
- 发表时间:2008
- 期刊:
- 影响因子:0
- 作者:A Henderson
- 通讯作者:A Henderson
Efficient encoding and rapid decoding for interactive visualization of large three-dimensional hyperspectral chemical images.
高效编码和快速解码,用于大型三维高光谱化学图像的交互式可视化。
- DOI:10.1002/rcm.3962
- 发表时间:2009
- 期刊:
- 影响因子:0
- 作者:Reichenbach SE
- 通讯作者:Reichenbach SE
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John Vickerman的其他文献
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{{ truncateString('John Vickerman', 18)}}的其他基金
Novel ion beams to enhance ionization in molecular secondary ion mass spectrometry
新型离子束增强分子二次离子质谱中的电离
- 批准号:
EP/K01353X/1 - 财政年份:2012
- 资助金额:
$ 13.99万 - 项目类别:
Research Grant
A new dynamic in mass spectral imaging for biological systems
生物系统质谱成像的新动态
- 批准号:
EP/G045623/1 - 财政年份:2009
- 资助金额:
$ 13.99万 - 项目类别:
Research Grant
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