Functional Bowel Disorders in Chinese Medicine

国际补充和替代医学研究中心(ICRC)的目标 应用程序是继续发展可持续的国际研究合作，将 协助保存香港传统中医药的知识和应用 还有中国。香港中文大学(中大)研究人员；综合医学中心 在马里兰大学，巴尔的摩大学，伊利诺伊大学，芝加哥大学，西悉尼大学， 和梅奥医学中心将合作进行严格的、多学科的肠道功能研究 精神障碍与中医。我们会在中大进行三个项目：第一个项目会评估 电针应激诱导的新生大鼠IBS模型的行为和内脏反应 疼痛和结肠、脊髓和中枢5-羟色胺能神经递质系统；项目#2将建立 利用体外回肠大鼠或豚鼠制剂的中草药制剂的生物效力，以及 使用新生大鼠应激诱导的IBS模型的安全性、不良反应和毒性。项目3将是一个试点项目 临床试验评估该中药制剂对IBS患者的安全性和剂量反应。支持 将由管理核心提供，该管理核心将协调计划并提供氛围 加强进一步的研究工作；植物核心负责认证、标准化和 草药质量控制；以及数据管理和统计分析核心，以提供 研究设计、实施和统计分析方面的专业知识。这些单位将共同解决科学问题 运用针灸和草药疗法治疗肠易激综合征，并进行中医翻译研究。 正在进行的合作将为发展强大的、多学科的、 竞争激烈、持久的研究努力，将科学严谨与传统的本土化研究相结合 知识。

The goal of this International Center for Research on Complementary and Alternative Medicine (ICRC) application is to continue development of a sustainable international research collaboration that will contribute to the preservation of knowledge and use of Traditional Chinese Medicine (TCM) in Hong Kong and China. Investigators from the Chinese University of Hong Kong (CUHK); Center for Integrative Medicine at the University of Maryland Baltimore; the University of Illinois, Chicago; the University of Western Sydney; and Mayo Medical Center will collaborate on rigorous, multi-disciplinary research on functional bowel disorders and TCM. We will conduct three projects at CUHK: Project #1 will evaluate the effect of electroacupuncture using a rat neonatal stress induced IBS model on behavioral and visceral responses to pain and colonic, spinal, and central serotonergic neurotransmitter systems; Project #2 will establish the biological potency of the TCM herbal preparation using in vitro ileal rat or guinea pig preparations, and the safety, adverse effects, and toxicity using the rat neonatal stress induced IBS model. Project #3 will be a pilot clinical trial evaluating the safety and dose-response of the herbal formulation in patients with IBS. Support will be provided by an Administrative Core, which will coordinate the program and provide an atmosphere to enhance further research efforts; a Botanical Core responsible for authentication, standardization, and quality control of herbal materials; and a Data Management and Statistical Analysis Core to provide expertise on study design, conduct, and statistical analyses. Together these units will address the science underlying the use of acupuncture and herbal therapy for IBS and conduct translational research in TCM. The ongoing collaboration will provide the foundation for development of a strong, multidisciplinary, competitive, and long-lasting research endeavor that will integrate scientific rigor with traditional, indigenous knowledge.