UCPPS 中的尿路上皮变化：尿液蛋白质组和生物标志物-猫眼课题宝

UCPPS 中的尿路上皮变化：尿液蛋白质组和生物标志物

批准号：

7570944

负责人：

ALVIN Y LIU

金额：

$13.0万

依托单位：

UNIVERSITY OF WASHINGTON

依托单位国家：

美国

项目类别：

财政年份：

2008

资助国家：

美国

项目状态：

已结题

起止时间：

2008-09-15 至 2013-06-30

来源：

https://reporter.nih.gov/project-details/7570944

关键词：

Address Antibodies Basic Science Bioinformatics Biological Biological Assay Biological Markers Biological Process Biopsy Biopsy Specimen Bladder Bladder Urothelial Cell Cell Cycle Cell Proliferation Cells Characteristics Chronic Prostatitis Clinical Clinical Data Clinical Trials Condition Data Data Analyses Databases Defect Diagnosis Diagnostic Disease Economic Burden Enrollment Epidemiologic Studies Epidermal Growth Factor Etiology Exclusion Female Floor Foundations Frequencies Functional disorder Funding Future Gene Expression Genes Genetic Genitourinary system Goals Growth Factor Guidelines Heparin Binding Immune Immunofluorescence Immunologic Individual Inflammation Inflammatory Inflammatory Response Interstitial Cystitis Invasive Laboratories Leukocytes Link Lower urinary tract Malignant Neoplasms Measures Mediator of activation protein Messenger RNA Molecular National Institute of Diabetes and Digestive and Kidney Diseases Natural History Noise Organ Pain Pain-Free Participant Pathogenesis Pathology Pathway Analysis Pathway interactions Patients Pattern Pelvis Peptides Persons Phenotype Physiological Potassium Prevention Procedures Process Production Prostatic Proteins Proteome Proteomics Rate Reporting Research Research Personnel Research Project Grants Reservations Sampling Scientist Sensory Serum Severities Sialoglycopeptides Signal Pathway Specificity Specimen Starvation Stress Substance P Symptoms Syndrome Technology Testing Tissues Translating Translational Research Twin Multiple Birth UPK3 gene Universities Urine Urologic Diseases Urothelial Cell Urothelium Washington Woman Work base chemokine chronic pelvic pain concept cost cytokine disease phenotype improved lower urinary tract symptoms men micturition urgency novel strategies painful bladder syndrome prognostic relating to nervous system research clinical testing response tandem mass spectrometry tool urinary urologic

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中文摘要

翻译

这些拟议研究直接涉及3个RFA目标。首先，我们提供基础/转化科学一项考虑UCPPS发病机制中局部泌尿生殖道因素的研究。其次，我们讨论RFA 要求进行研究，以确定和验证UCPPS的生物标志物。我们的策略是利用最先进的蛋白质组学以一种新的方法分析IC/PBS和CP/CPPS患者的尿液标本，验证新的生物标志物，可能会改善诊断，预测UCPPS自然史，并预测或测量对治疗的反应。第三，这项工作还解决了RFA优先阐明发病机制关于UCPPS这些蛋白质/肽标记物可能通过对UCPPS重要的特定细胞途径起作用病理值得注意的是，如果成功，这项技术可以在整个网络中推广，为未来的临床试验和更有针对性的治疗特定的尿路上皮缺陷奠定了基础。

英文摘要

These proposed studies directly address 3 RFA objectives. First, we offer a basic/translational science study that considers local urogenital tract factors in the pathogenesis of UCPPS. Second, we address RFA request for studies to identify and validate biomarkers for UCPPS. Our strategy uses cutting-edge proteomic analysis of urine specimens from patients with IC/PBS and CP/CPPS in a new approach to identify and validate new biomarkers that potentially could improve diagnosis, predict UCPPS natural history, and predict or measure response to treatment. Third, this work also addresses the RFA priority to elucidate the pathogenesis of UCPPS. These protein/peptide markers may act via specific cellular pathways important to UCPPS pathology. Notably, if successful, this technology can be exported across the Network and could establish a foundation for future clinical trials and for more targeted therapies to treat specific urothelial defects.

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