Urothelial Changes in UCPPS: Urinary Proteomes and Biomarkers

UCPPS 中的尿路上皮变化：尿液蛋白质组和生物标志物

• 批准号: 7570944
• 负责人: ALVIN Y LIU
• 金额: $ 13万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7570944
• 关键词: Address; Antibodies; Basic Science; Bioinformatics; Biological; Biological Assay; Biological Markers; Biological Process; Biopsy; Biopsy Specimen; Bladder; Bladder Urothelial Cell; Cell Cycle; Cell Proliferation; Cells; Characteristics; Chronic Prostatitis; Clinical; Clinical Data; Clinical Trials; Condition; Data; Data Analyses; Databases; Defect; Diagnosis; Diagnostic; Disease; Economic Burden; Enrollment; Epidemiologic Studies; Epidermal Growth Factor; Etiology; Exclusion; Female; Floor; Foundations; Frequencies; Functional disorder; Funding; Future; Gene Expression; Genes; Genetic; Genitourinary system; Goals; Growth Factor; Guidelines; Heparin Binding; Immune; Immunofluorescence Immunologic; Individual; Inflammation; Inflammatory; Inflammatory Response; Interstitial Cystitis; Invasive; Laboratories; Leukocytes; Link; Lower urinary tract; Malignant Neoplasms; Measures; Mediator of activation protein; Messenger RNA; Molecular; National Institute of Diabetes and Digestive and Kidney Diseases; Natural History; Noise; Organ; Pain; Pain-Free; Participant; Pathogenesis; Pathology; Pathway Analysis; Pathway interactions; Patients; Pattern; Pelvis; Peptides; Persons; Phenotype; Physiological; Potassium; Prevention; Procedures; Process; Production; Prostatic; Proteins; Proteome; Proteomics; Rate; Reporting; Research; Research Personnel; Research Project Grants; Reservations; Sampling; Scientist; Sensory; Serum; Severities; Sialoglycopeptides; Signal Pathway; Specificity; Specimen; Starvation; Stress; Substance P; Symptoms; Syndrome; Technology; Testing; Tissues; Translating; Translational Research; Twin Multiple Birth; UPK3 gene; Universities; Urine; Urologic Diseases; Urothelial Cell; Urothelium; Washington; Woman; Work; base; chemokine; chronic pelvic pain; concept; cost; cytokine; disease phenotype; improved; lower urinary tract symptoms; men; micturition urgency; novel strategies; painful bladder syndrome; prognostic; relating to nervous system; research clinical testing; response; tandem mass spectrometry; tool; urinary; urologic

These proposed studies directly address 3 RFA objectives. First, we offer a basic/translational science study that considers local urogenital tract factors in the pathogenesis of UCPPS. Second, we address RFA request for studies to identify and validate biomarkers for UCPPS. Our strategy uses cutting-edge proteomic analysis of urine specimens from patients with IC/PBS and CP/CPPS in a new approach to identify and validate new biomarkers that potentially could improve diagnosis, predict UCPPS natural history, and predict or measure response to treatment. Third, this work also addresses the RFA priority to elucidate the pathogenesis of UCPPS. These protein/peptide markers may act via specific cellular pathways important to UCPPS pathology. Notably, if successful, this technology can be exported across the Network and could establish a foundation for future clinical trials and for more targeted therapies to treat specific urothelial defects.

这些拟议研究直接涉及3个RFA目标。首先，我们提供基础/转化科学 一项考虑UCPPS发病机制中局部泌尿生殖道因素的研究。其次，我们讨论RFA 要求进行研究，以确定和验证UCPPS的生物标志物。我们的策略是利用最先进的蛋白质组学 以一种新的方法分析IC/PBS和CP/CPPS患者的尿液标本， 验证新的生物标志物，可能会改善诊断，预测UCPPS自然史，并预测或 测量对治疗的反应。第三，这项工作还解决了RFA优先阐明发病机制 关于UCPPS这些蛋白质/肽标记物可能通过对UCPPS重要的特定细胞途径起作用 病理值得注意的是，如果成功，这项技术可以在整个网络中推广， 为未来的临床试验和更有针对性的治疗特定的尿路上皮缺陷奠定了基础。