PILOT STUDY FOR IDENTIFYING URINARY PROSTATE CANCER BIOMARKERS

鉴定尿路前列腺癌生物标志物的试点研究

• 批准号: 8365472
• 负责人: ALVIN Y LIU
• 金额: $ 2.87万
• 依托单位: BATTELLE PACIFIC NORTHWEST LABORATORIES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365472
• 关键词: Biological Markers; Biology; Biopsy; Development; Funding; Genomics; Grant; Investigation; Malignant Neoplasms; Malignant neoplasm of prostate; National Center for Research Resources; Pilot Projects; Principal Investigator; Proteins; Proteomics; Research; Research Infrastructure; Resources; Sampling; Screening for cancer; Source; Technology; Testing; United States National Institutes of Health; Urine; cancer cell; cost; multiple reaction monitoring; serum PSA; urinary

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Urinary prostate cancer protein biomarkers are important for early cancer detection. A urine test at this point can significantly reduce the number of unnecessary biopsies done as a result of elevated serum PSA. The application of genomics to cancer cells has allowed the identification of a number of candidate biomarkers for further investigations. This pilot study will utilize the advanced targeted proteomic technology using multiple reaction monitoring (MRM) under the resource center for testing the discriminatory power of identified cancer proteins in urine samples. The application is also anticipated to drive further development and optimization of the targeted MRM technology.

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