INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY

描述（由申请人提供） 全球环境卫生问题只能通过多个国家和机构的合作行动来解决，但这需要有效的领导和协调。 国际化学品安全方案（化学品安全方案）成立于1980年，是对环境污染物造成的潜在健康风险进行科学评估的牵头国际协调机构。 国际化学品安全方案由世界卫生组织（卫生组织）管理，但涉及许多其他联合国、区域、国际、国家和非政府组织。 化学品安全方案通过国际公认的科学专家组成的广泛多样的网络的努力完成其大部分工作。 国家卫生研究所/国家环境卫生科学研究所在国际化学品安全方案的形成过程中发挥了关键作用，国家环境卫生科学研究所（内部和外部）继续在国际化学品安全方案的许多活动中发挥重要的领导作用。 卫生组织/国际化学品安全方案区域间研究股设在国家环境卫生研究所校园内，以执行国家环境卫生研究所-卫生组织合作协定所支持的活动，该协定涉及以下全球性跨领域环境卫生问题：⑴儿童健康与环境; ⑵毒理基因组学/基因-环境相互作用/生物标志物; ⑶持久性有毒物质和内分泌干扰物; ⑷改进风险评估方法;（5）制定综合风险评估方法，重点是混合物。 为实现这些目标，已经制定了一个逐步实施的原型战略，该战略非常有效。 这一战略将区域办法与灵活的模块化进程相结合，考虑到不可预见的科学机会的不确定性，产生独特的科学知识，并最终导致发展中国家和发达国家科学家之间的研究合作。此外，这一战略还促进了更多的多伙伴支助和协作行动。 合作协议支持的活动产生了大量出版物、科学家和卫生保健专业人员培训、合作研究机会、生成独特的科学信息和启动数据收集档案、教育、提高认识和信息传播。各国利用这些产品在国家和区域一级制定基于证据的公共卫生、预防和补救政策。

DESCRIPTION (provided by applicant) Global environmental health concerns can only be addressed through the cooperative actions of multiple countries and institutions, but this requires effective leadership and coordination. The International Programme on Chemical Safety (IPCS) was established in 1980 as the lead international coordinating body to provide science-based assessments of the potential health risks posed by environmental contaminants. IPCS is managed by the World Health Organization (WHO) but involves many other United Nations, regional, international, national, and non-governmental organizations. IPCS accomplishes most of its work through the efforts of a broad diverse network of internationally recognized scientific experts. The National Institute of Health (NIH)/National Institute of Environmental Health Sciences (NIEHS) played a key role in the formation of IPCS, and NIEHS (intramural and extramural) continues to play a significant leadership role for many IPCS activities. A WHO/IPCS Interregional Research Unit (IRRU) is located on the NIEHS campus to implement the activities supported by the NIEHS-WHO Cooperative Agreement, which addresses the following global cross-cutting environmental health issues: 1) children's health and the environment; 2) toxicogenomics/gene-environment interactions/biomarkers; 3) persistent toxic substances and endocrine disruptors; 4) improved risk assessment methodologies; and 5) development of an integrated risk assessment approach with an emphasis on mixtures. A prototype, step-wise implementation strategy, shown to work very effectively has been developed to implement these aims. This strategy combines a regional approach with a flexible, modular process that allows for uncertainties of unforeseen scientific opportunities, generates unique scientific knowledge, and ultimately leads to the collaboration of research among scientists in developing and developed countries. In addition, this strategy has served as a catalyst for additional multi-partner support and collaborative actions. The activities supported by the Cooperative Agreement result in numerous publications, training of scientists and health care professionals, collaborative research opportunities, generation of unique scientific information and initiation of data collection archives, education, awareness raising, and information dissemination. Countries use these products to put in place evidence based public health, prevention, and remediation policies at the national and regional level.