Insulin Signaling, Lipoproteins and Atherosclerosis
Insulin Signaling, Lipoproteins and Atherosclerosis
批准号:
7329715
负责人:
ALAN richard TALL
金额:
$55.25万
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-07-01 至 2012-06-30
关键词:
Apolipoproteins BApoptosisApoptoticAreaAtherosclerosisCD36 geneCaenorhabditis elegansCaloric RestrictionCellsCholesterolCollaborationsDataDiabetes MellitusEnzymesExclusionFailureFoam CellsGeneticGlucoseHepaticHepatocyteHistonesHyperinsulinismInduction of ApoptosisInsulinInsulin ReceptorInsulin ResistanceInsulin Signaling PathwayKnock-outLDL Cholesterol LipoproteinsLaboratoriesLeptinLesionLigationLinkLipoproteinsLiverLongevityLow-Density LipoproteinsMammalian CellMediatingMetabolicMetabolismModelingModificationMolecular TargetMusNecrosisNuclearNumbersOrthologous GenePeripheralPhosphorylationPlasmaPredispositionProtein OverexpressionProteinsReagentRegulationRoleSerumSignal PathwaySignal TransductionSirtuinsStimulusStressTLR4 geneTestingTransgenesVery low density lipoproteinWeekWorkbasebiological adaptation to stressdeprivationfeedingin vivoinsulin signalinginterestknock-downlipid biosynthesismacrophageoxidized low density lipoproteinresearch studyresponsescavenger receptortranscription factoruptake
中文摘要
IAmtehcehroasncislemrostiacrevapsocourlayrudnisdearsteooisd.aImnsaujloinr与oartbthideitycealnludladrelaevthelincaduiasbeestemsa,的关系不同于传统的管理方式
糖尿病的症状。在最近与Tabas和Accili实验室的合作研究中,我们表明
[中英文摘要][晓雨-0920交稿]这是一种新的rmeaicsedisupltaykedeofemctoivdeifieindsuLliDnLsiagndalincgr,检测方法。
对Fc负荷等刺激诱导的细胞凋亡有明显的抑制作用。细胞凋亡的易感性与未能诱导
Iinktot aLcDtiLvRity-/-哑巴isntrfeosrmsaretisopnoonfsea.dvAacnccoerdinlegslyio,nbsoncoenmtaainrrinogw itnracrnesapslaendtantuiomnbferorsmofIRapdoepfictoietinct小鼠
Idminecacrcerreaoaspsehedadgseaigsthneanrliondsgclalterhgroeosruigsnh.eTcprhoretiscuencrvoderedrslyh.ineIngpahtiycpoInRtvhse,rswsiseromefoftohduiesnl、dpLrtDojLehRcat-v/i-semtlhoiacweteinrwsVituhLliDnpLer/reLipsDhisLetarlaenlvceIRlswdaoenrfsidceinesncy和
如果他们或安全的话,他们可能会受到威胁,他们也会受到威胁,也会受到威胁。
肝脏胰岛素信号与脂蛋白代谢改变的关系。在AIM 1WE中
Iwitllhcdoellafebcotrivaeteintosuilninvesigtingaltiengt.heInmpeacrthicaunliasrmwseawndill cdoentesremqiunencifedseocrfeinacsredasIRedsiagpnoaplintogsiasnidn ImowaecroApkhtaagcetty
导致核FoxO1/3活性增加,内质网应激/CHOP诱导和细胞凋亡增加。在AIM 2
Iwleesiownilallemxtaecnrdopohuarginesvivinocrsetuadsiesmanadcrfouprhthaegreaxpoloprteosthiseahnydpoathesriosmthaactodmepfelecxtivtye.在RseullaintsDigstuadlinegs中
项目1和3将测试SRA和FoxO在调节这些影响方面的作用。在目标3中,我们将确定
Idinecgreradsaetdionhewpiathtiicninthseulisnecsrigentoarlyinpgaltehawdasyt.oTdhecsreeaxspeedrhimepeantisc cFomxOpl1emacetnivtiyasnedothofuPsroinrte3asexDamapinoinBg
IipmropvaidcteonfehwepmatoiclecFuolxaor i1nsoivgehrtsexipntroestshieoncaounsheespoaftidcialibpeidticanddysllipipoidperomteiainamndetiatsbovlaismcu.laTrhicsopmropjleicattimonasy.
英文摘要
IAmtehcehroasncislemrostiacrevapsocourlayrudnisdearsteooisd.aImnsaujloinr creasuisetaonfcme oartbthideitycealnludladrelaevthelincaduiasbeestemsa,nbyutotfhteheucnodmerplylicnagtions
of diabetes. In recent collaborative studies with the Tabas and Accili laboratories, we have shown that
Itmrancsrcorpiphtaiogneasl feroxmpreinssuiolin oref cCeDp3to6r a(InRd) SdeRfAic,ieinct rmeaicsedisupltaykedeofemctoivdeifieindsuLliDnLsiagndalincgr,eiansceredaseudscpeopstitb-ility
to apoptosis induced by FC loading and other stimuli. Apoptotic susceptibility is related to a failure to induce
IAinktot aLcDtiLvRity-/-dumrinceg trheesuEltRs isntrfeosrmsaretisopnoonfsea.dvAacnccoerdinlegslyio,nbsoncoenmtaainrrinogw itnracrnesapslaendtantuiomnbferorsmofIRapdoepfictoietinct mice
Idminecacrcerreaoaspsehedadgseaigsthneanrliondsgclalterhgroeosruigsnh.eTcprhoretiscuencrvoderedrslyh.ineIngpahtiycpoInRtvhse,rswsiseromefoftohduiesnl,dpLrtDojLehRcat-v/i-semtlhoiacweteinrwsVituhLliDnpLer/reLipsDhisLetarlaenlvceIRlswdaoenrfsidceinesncy and
Ifautrhtheerorsecvlearlousaiste, maceticnhganbiostmhsatlinthkeinlgevinesl uolfinthresviesstasneclewainll,mancdroaplshoaginetfhoeamlivecre.llTshteo parthopeorossacllwerilolsies,ekantod also
the relationship between insulin signaling in the liver and alterations in lipoprotein metabolism. In Aim 1we
Iwitllhcdoellafebcotrivaeteintosuilninvesigtingaltiengt.heInmpeacrthicaunliasrmwseawndill cdoentesremqiunencifedseocrfeinacsredasIRedsiagpnoaplintogsiasnidn lmowaecroApkhtaagcetsivity
leads to increased nuclear FoxO1/3 activity, increased ER stress/CHOP induction and apoptosis. In Aim 2
Iwleesiownilallemxtaecnrdopohuarginesvivinocrsetuadsiesmanadcrfouprhthaegreaxpoloprteosthiseahnydpoathesriosmthaactodmepfelecxtivtye. inRseullaintesdigsntuadliniegs in
Projects 1 and 3 will test the role of SRA and FoxOs in mediating these effects. In Aim 3 we will determine if
Idinecgreradsaetdionhewpiathtiicninthseulisnecsrigentoarlyinpgaltehawdasyt.oTdhecsreeaxspeedrhimepeantisc cFomxOpl1emacetnivtityhoasnedothf uPsroinjecrte3asexdamapinoinBg the
IipmropvaidcteonfehwepmatoiclecFuolxaOr i1nsoivgehrtsexipntroestshieoncaounsheespoaftidcialibpeidticanddysllipipoidperomteiainamndetiatsbovlaismcu.laTrhicsopmropjleicattimonasy.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
New therapeutic approaches in clonal hematopoiesis and atherosclerosis
-
批准号:10719058
-
项目类别:
-
资助金额:$69.47万
-
财政年份:2023
-
负责人:ALAN richard TALL
-
依托单位:
Clonal hematopoiesis, inflammasomes and atherosclerosis
-
批准号:10581564
-
项目类别:
-
资助金额:$54.41万
-
财政年份:2021
-
负责人:ALAN richard TALL
-
依托单位:
Clonal hematopoiesis, inflammasomes and atherosclerosis
-
批准号:10339390
-
项目类别:
-
资助金额:$54.41万
-
财政年份:2021
-
负责人:ALAN richard TALL
-
依托单位:
TTC39B in Metabolism
-
批准号:10064114
-
项目类别:
-
资助金额:$47.35万
-
财政年份:2014
-
负责人:ALAN richard TALL
-
依托单位:
TTC39B in Metabolism
-
批准号:10308034
-
项目类别:
-
资助金额:$46.69万
-
财政年份:2014
-
负责人:ALAN richard TALL
-
依托单位:
TTC39B in Metabolism
-
批准号:9386771
-
项目类别:
-
资助金额:$40.0万
-
财政年份:2014
-
负责人:ALAN richard TALL
-
依托单位:
TTC39B in Metabolism
-
批准号:8962161
-
项目类别:
-
资助金额:$40.0万
-
财政年份:2014
-
负责人:ALAN richard TALL
-
依托单位:
Hyperinsulinemia, mTOR activity and plasma lipoproteins
-
批准号:8275590
-
项目类别:
-
资助金额:$38.63万
-
财政年份:2012
-
负责人:ALAN richard TALL
-
依托单位:
ABCA1/G1 and LXRs in Atherogenesis
-
批准号:10171606
-
项目类别:
-
资助金额:$51.04万
-
财政年份:2011
-
负责人:ALAN richard TALL
-
依托单位:
ABCG1 and endothelial function
-
批准号:8207861
-
项目类别:
-
资助金额:$40.25万
-
财政年份:2011
-
负责人:ALAN richard TALL
-
依托单位:
ABCA1/ABCG1 in myeloid populations and atherogenesis
-
批准号:8675919
-
项目类别:
-
资助金额:$39.45万
-
财政年份:2011
-
负责人:ALAN richard TALL
-
依托单位:
ABCA1/G1 and LXRs in Atherogenesis
-
批准号:10406915
-
项目类别:
-
资助金额:$50.26万
-
财政年份:2011
-
负责人:ALAN richard TALL
-
依托单位:
ABCA1/ABCG1 in myeloid populations and atherogenesis
-
批准号:8085576
-
项目类别:
-
资助金额:$40.25万
-
财政年份:2011
-
负责人:ALAN richard TALL
-
依托单位:
ABCG1 and endothelial function
-
批准号:8038742
-
项目类别:
-
资助金额:$40.25万
-
财政年份:2011
-
负责人:ALAN richard TALL
-
依托单位:
ABCA1/G1 and LXRs in Atherogenesis
-
批准号:8889088
-
项目类别:
-
资助金额:$40.38万
-
财政年份:2011
-
负责人:ALAN richard TALL
-
依托单位:
ABCA1/ABCG1 in myeloid populations and atherogenesis
-
批准号:8269807
-
项目类别:
-
资助金额:$40.25万
-
财政年份:2011
-
负责人:ALAN richard TALL
-
依托单位:
ABCA1/ABCG1 in myeloid populations and atherogenesis
-
批准号:8465264
-
项目类别:
-
资助金额:$38.32万
-
财政年份:2011
-
负责人:ALAN richard TALL
-
依托单位:
ABCG1 and endothelial function
-
批准号:8402623
-
项目类别:
-
资助金额:$38.32万
-
财政年份:2011
-
负责人:ALAN richard TALL
-
依托单位:
ABCA1/G1 and LXRs in Atherogenesis
-
批准号:9889981
-
项目类别:
-
资助金额:$51.79万
-
财政年份:2011
-
负责人:ALAN richard TALL
-
依托单位:
Cholesterol efflux, CHIP and inflammasome activation
-
批准号:10735980
-
项目类别:
-
资助金额:$61.69万
-
财政年份:2011
-
负责人:ALAN richard TALL
-
依托单位:
国内基金
海外基金
登录
查看更多内容
Epac1/2通过蛋白酶体调控中性粒细胞NETosis和Apoptosis在急性肺损伤中的作用研究
-
批准号:LBY21H010001
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2020
-
负责人:郑绪阳
-
依托单位:
基于Apoptosis/Ferroptosis双重激活效应的天然产物AlbiziabiosideA的抗肿瘤作用机制研究及其结构改造
-
批准号:81703335
-
项目类别:青年科学基金项目
-
资助金额:20.0万元
-
批准年份:2017
-
负责人:卫高菲
-
依托单位:
双肝移植后Apoptosis和pyroptosis在移植物萎缩差异中的作用和供受者免疫微环境变化研究
-
批准号:81670594
-
项目类别:面上项目
-
资助金额:58.0万元
-
批准年份:2016
-
负责人:陈昊
-
依托单位:
Serp-2 调控apoptosis和pyroptosis 对肝脏缺血再灌注损伤的保护作用研究
-
批准号:81470791
-
项目类别:面上项目
-
资助金额:73.0万元
-
批准年份:2014
-
负责人:董家鸿
-
依托单位:
Apoptosis signal-regulating kinase 1是七氟烷抑制小胶质细胞活化的关键分子靶点?
-
批准号:81301123
-
项目类别:青年科学基金项目
-
资助金额:23.0万元
-
批准年份:2013
-
负责人:王海莲
-
依托单位:
APO-miR(multi-targeting apoptosis-regulatory miRNA)在前列腺癌中的表达和作用
-
批准号:81101529
-
项目类别:青年科学基金项目
-
资助金额:22.0万元
-
批准年份:2011
-
负责人:陈雪芹
-
依托单位:
放疗与细胞程序性死亡(APOPTOSIS)相关性及其应用研究
-
批准号:39500043
-
项目类别:青年科学基金项目
-
资助金额:9.0万元
-
批准年份:1995
-
负责人:梁克
-
依托单位: