Defining the mechanism(s) by which the cellular inhibitor of apoptosis protein 2 (cIAP2) contributes to early stage atherosclerosis development by directly promoting the participation of key apoptotic pathways within lesion-associated macrophages

确定凋亡蛋白细胞抑制剂 2 (cIAP2) 通过直接促进病变相关巨噬细胞内关键凋亡途径的参与来促进早期动脉粥样硬化发展的机制

• 批准号: 191299
• 负责人: Whitman Stewart C
• 金额: $ 48.64万
• 依托单位: University of Ottawa Heart Institute
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-09-01 至 2014-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=191299&lang=en
• 关键词: Apoptosis; Atherosclerosis; Bone Marrow Transplantation; Macrophage; Mouse Models Of Disease

Objective: Under different circumstances both anti- and pro-apoptotic mechanisms contribute to the development and progression of atherosclerosis, yet the molecular events leading to these processes are not clearly understood. Macrophages are a key compon

目的：在不同的情况下，抗细胞凋亡和促细胞凋亡机制都有助于动脉粥样硬化的发生和进展，但导致这些过程的分子事件尚不清楚。宏程序是一个关键组件，