CONTROL SYSTEM FOR MRI MONITORED THERMAL THERAPIES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 项目摘要 我们建议开发、实施和验证计算机化控制系统用于MR监测的热治疗（间质激光热治疗和冷冻治疗），该系统将连接到我们的0.5T开放配置介入MR扫描仪上。该系统将利用3D MRI信息，提供听觉和视觉预先警告信号以及治疗终点的报警信号。我们的目标是直接满足癌症治疗的临床需求，即对异质组织中的肿瘤热治疗进行准确的3D时空监测和控制，目前超出了人类的能力，以保证患者的安全性，同时优化治疗效果。我们提出的系统将在达到终点之前提供可识别的先前警告信号，并且当热暴露水平或治疗边界满足或超过预定义的3D边界或安全限制时，在热治疗终点发生时提供警报信号。 项目开始日期：2001年8月1日 项目结束日期：2007年7月31日 未来计划 重点将放在开始第二阶段试验，在人体冷冻治疗病例中使用控制系统。在软件模块2软件完成之前，系统将仅限于使用（经确认的）基于光流的预测方法进行监测。 由于软件编程和软件集成方面的困难，软件模块二的进展似乎比预期的要慢。 合作对NCIGT的好处 U41为该项目提供了帮助，因为它支持我们MRT套件中发生的热疗，这是该项目中开发的软件的主要目标。 对项目的好处 该项目为U41成像和MR引导治疗核心提供帮助，因为该项目是一个技术开发项目，应提高BWH热治疗的技术和能力水平。 出版物 斯图尔特·G作者：Maryellen R. M.放大图片作者：Michael R.放大图片作者：莫里森，Eric货车Sonnenberg，Sridhar Shankar，Kelly H.作者：Simon K.沃菲尔德，“MRI引导下经皮冷冻治疗肝转移瘤的三维评估”，美国X线杂志。 R.中村、K.Tuncali、P.R.莫里森、N.Hata、S.G.Silverman、R.Kikinis、F.A.Jolesz、G. P. Zientara，“MR引导冷冻治疗的控制系统-使用自动分割和3D光流进行治疗边界的短期预测”，计算机科学讲义（Springer-Verlag，Heidelberg），第7届医学图像计算和计算机辅助干预MICCAI国际会议，圣马洛法国，2004年9月，第3217卷，PT.第二卷，第542 -550页。 D.Mitsouras、W.S.Hoge、F. J. Rybicki、A.Edelman、G. P. Zientara，“使用多个接收器线圈的非傅立叶编码并行MRI”，Magn Res Med，52：321-328，2004年。 摘要 Kemal Tuncali、加里P Zientara、Ryoichi中村、Paul R莫里森、Simon K沃菲尔德、Stuart G Silverman，MRI引导经皮冷冻消融术的3D计算机化监测：动物模型和回顾性临床病例应用中的系统确认，北美放射学会第91届科学大会和年会摘要，芝加哥，伊利诺伊州，2005年11月。 K Tuncali，R中村，EN Wildenberg，PR莫里森，SK沃菲尔德，GP Zientara，SG Silverman，“图像引导经皮肿瘤消融的3D计算机化监测：系统在动物模型和回顾性临床病例应用中的确认”，第五届介入MRI研讨会摘要，马萨诸塞州波士顿，2004年10月。 D. Mitsouras，R.V. Mulkern，A.S. Edelman，G. P. Zientara，F. J. Rybicki，“3D超快速自旋回波内容积MRI：神经成像应用”，第12届国际磁共振学会会议摘要，京都，日本，2004年5月。 D Mitsouras、R V Mulkern、A Edelman、G P Zientara、F J Rybicki，“采用超短、非选择性、硬脉冲重聚焦放射性脉冲的两个缩小视野3D快速自旋回波磁共振成像方法的神经成像应用”，北美放射学会第90届科学大会和年会摘要，芝加哥，伊利诺伊州，2004年11月。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Project Summary We propose to develop, implement, and validate use of a computerized control system for MR-monitored thermal therapies (interstitial laser thermal therapy and cryotherapy) that is to be attached to our 0.5T open configuration interventional MR scanner. The system will utilize 3D MRI information, providing audible and visual prior warning signals and an alarm signal at the therapy endpoint. We aim to directly answer the cancer treatment clinical need for accurate 3D spatial-temporal monitoring and control of tumor thermal therapies in heterogeneous tissue, currently beyond human capability, to guarantee patient safety while optimizing therapy effectiveness. Our proposed system will provide recognizable prior warning signals before the endpoint is reached, and an alarm signal at the instance when the thermal therapy endpoint occurs, as the thermal exposure level or therapy boundary meets or exceeds predefined 3D boundaries or safety limits. Project Start: 01-AUG-2001 Project End: 31-JUL-2007 Plans Going Forward Emphasis will be on beginning Trial Phase Two, the use of the control system in human cryotherapy cases. The system will be limited to using the (validated) optical flow-based prediction method for monitoring until the Software Module Two software is complete. The progress on Software Module Two appears to be slower than anticipated due to the software programming and software integration difficulties. Benefits of Collaboration to the NCIGT The U41 provides aid to the project in that it supports the thermal therapies occuring in our MRT suite that are the prime target of the software developed in this project. Benefits to the Project The project provides aid to the U41 Imaging and MR-guided therapy cores in that this project is a technical development project that should raise the technical and level of the capabilities available for thermal therapies at BWH. Publications Stuart G. Silverman, Maryellen R. M. Sun, Kemal Tuncali, Paul R. Morrison, Eric van Sonnenberg, Sridhar Shankar, Kelly H. Zou, Simon K. Warfield, "Three-Dimensional Assessment of MRI-Guided Percutatneous Cryotherapy of Liver Metastases, American Journal of Roentgenology. R.Nakamura, K.Tuncali, P.R.Morrison, N.Hata, S.G.Silverman, R.Kikinis, F.A.Jolesz, G.P.Zientara, "Control System for MR-Guided Cryotherapy - Short-Term Prediction of Therapy Boundary Using Automatic Segmentation and 3D Optical Flow", Lecture Notes in Computer Science (Springer-Verlag, Heidelberg), 7th Intl Conf. Medical Image Computing and Computer-Assisted Intervention MICCAI, Saint-Malo France, Sept 2004, Vol. 3217, Pt. II, pp.542-550. D.Mitsouras, W.S.Hoge, F.J.Rybicki, A.Edelman, G.P.Zientara, " Non-Fourier Encoded Parallel MRI Using Multiple Receiver Coils", Magn Res Med, 52:321-328, 2004. Abstracts Kemal Tuncali, Gary P Zientara, Ryoichi Nakamura, Paul R Morrison, Simon K Warfield, Stuart G Silverman, 3D Computerized Monitoring of MRI-guided Percutaneous Cryoablations: Validation of the System in an Animal Model and Retrospective Clinical Case Applications, Abstract for Radiological Society of North America's 91st Scientific Assembly and Annual Meeting, Chicago, Illinois, November 2005. K Tuncali, R Nakamura, EN Wildenberg, PR Morrison, SK Warfield, GP Zientara, SG Silverman, "3D Computerized Monitoring of Image-Guided Percutaneous Tumor Ablations: Validation of the System in an Animal Model and Retrospective Clinical Case Applications", Abstract for the 5th Interventional MRI Symposium, Boston, MA, October 2004. D. Mitsouras, R.V. Mulkern, A.S. Edelman, G.P.Zientara, F.J.Rybicki, "3D Ultra-Fast Spin Echo Inner Volume MRI: Neuroimaging Applications", Abstract for 12th Meeting Intl Society of Magnetic Resonance, Kyoto, Japan, May 2004. D Mitsouras , R V Mulkern, A Edelman, G P Zientara, F J Rybicki, "Neuroimaging Applications of Tow Reduced Field of View 3D Fast Spin Echo Magnetic Resonance Imaging Methods with Ultrashort, Non-Selective, Hard-Pulse Refocusing Radiofrequency Pulses", Abstract for Radiological Society of North America's 90th Scientific Assembly and Annual Meeting, Chicago, Illinois, November 2004.