CONTROL SYSTEM FOR MRI MONITORED THERMAL THERAPIES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 项目摘要 我们建议开发、实施和验证用于MR监测的热疗(间质激光热疗和冷冻治疗)的计算机控制系统的使用，该系统将连接到我们的0.5T开放式介入性MR扫描仪。该系统将利用3D MRI信息，在治疗终点处提供音频和视觉预先警告信号和警报信号。我们的目标是直接满足癌症治疗的临床需求，即对目前超出人类能力范围的异质组织中的肿瘤热疗进行准确的3D时空监测和控制，以确保患者的安全，同时优化治疗效果。我们建议的系统将在到达终点之前提供可识别的预先警告信号，并在热疗终点发生时提供警报信号，因为热暴露水平或治疗边界达到或超过预定义的3D边界或安全限制。 项目开始时间：2001年8月1日 项目结束：2007年7月31日 未来的计划 重点将放在开始试验第二阶段，即控制系统在人类冷冻治疗病例中的使用。该系统将仅限于使用(经过验证的)基于光流的预测方法进行监测，直到软件模块2软件完成。 由于软件编程和软件集成方面的困难，软件模块2的进展似乎比预期的要慢。 协作给NCIGT带来的好处 U41为该项目提供了帮助，因为它支持我们的MRT套件中发生的热疗，这些热疗是该项目开发的软件的主要目标。 给项目带来的好处 该项目为U41成像和核磁共振引导的治疗核心提供了援助，因为该项目是一个技术开发项目，应该会提高BWH现有热疗能力的技术和水平。 出版物 Stuart G.Silverman、Maryellen R.M.Sun、Kemal Tuncali、Paul R.Morrison、Eric van Sonnenberg、Sridhar Shankar、Kelly H.Zou、Simon K.Warfield，“3D评估MRI引导的经皮肝转移冷冻疗法”，美国放射学杂志。 R.Nakamura，K.Tuncali，P.R.Morrison，N.Hata，S.G.Silverman，R.Kikinis，F.A.Jolesz，G.P.Zientara，“MR引导冷冻治疗的控制系统-使用自动分割和3D光流对治疗边界的短期预测”，计算机科学讲稿(Springer-Verlag，Heidelberg)，第七届国际会议。医学图像计算和计算机辅助干预MICCAI，法国圣马洛，2004年9月，第3217卷，PT。第二，第542-550页。 D·米苏拉斯、W·S·霍格、F.J.雷比基、A·埃德尔曼、G·P·齐恩塔拉，《使用多个接收器线圈的非傅立叶编码并行磁共振成像》，Magn res Med，52：321-328,2004。 摘要 Kemal Tuncali，Gary P Zientara，Ryoichi Nakamura，Paul R Morrison，Simon K Warfield，Stuart G Silverman，3D计算机化监测MRI引导的经皮冷冻消融：动物模型中系统的验证和回顾性临床病例应用，北美放射学会第91届科学大会摘要和年会，2005年11月，伊利诺伊州芝加哥。 K Tuncali、R Nakamura、En Wildenberg、PR Morison、SK Warfield、GP Zientara、SG Silverman，“图像引导经皮肿瘤消融的3D计算机化监控：在动物模型中对系统的验证和回顾性临床病例应用”，第五届介入性核磁共振研讨会摘要，波士顿，马萨诸塞州，2004年10月。 D.Mitouras，R.V.Mulkern，A.S.Edelman，G.P.Zientara，F.J.Rabicki，“3D超快自旋回声内体积磁共振成像：神经成像应用”，第12次会议摘要，国际磁共振学会，日本京都，2004年5月。 D Mitouras、R V Mulkern、A Edelman、G P Zientara、F J Robicki，“超短、非选择性、硬脉冲重聚焦射频脉冲的两个缩小视场3D快速自旋回波磁共振成像方法的神经成像应用”，北美放射学会第90届科学大会和年会摘要，2004年11月，伊利诺伊州芝加哥。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Project Summary We propose to develop, implement, and validate use of a computerized control system for MR-monitored thermal therapies (interstitial laser thermal therapy and cryotherapy) that is to be attached to our 0.5T open configuration interventional MR scanner. The system will utilize 3D MRI information, providing audible and visual prior warning signals and an alarm signal at the therapy endpoint. We aim to directly answer the cancer treatment clinical need for accurate 3D spatial-temporal monitoring and control of tumor thermal therapies in heterogeneous tissue, currently beyond human capability, to guarantee patient safety while optimizing therapy effectiveness. Our proposed system will provide recognizable prior warning signals before the endpoint is reached, and an alarm signal at the instance when the thermal therapy endpoint occurs, as the thermal exposure level or therapy boundary meets or exceeds predefined 3D boundaries or safety limits. Project Start: 01-AUG-2001 Project End: 31-JUL-2007 Plans Going Forward Emphasis will be on beginning Trial Phase Two, the use of the control system in human cryotherapy cases. The system will be limited to using the (validated) optical flow-based prediction method for monitoring until the Software Module Two software is complete. The progress on Software Module Two appears to be slower than anticipated due to the software programming and software integration difficulties. Benefits of Collaboration to the NCIGT The U41 provides aid to the project in that it supports the thermal therapies occuring in our MRT suite that are the prime target of the software developed in this project. Benefits to the Project The project provides aid to the U41 Imaging and MR-guided therapy cores in that this project is a technical development project that should raise the technical and level of the capabilities available for thermal therapies at BWH. Publications Stuart G. Silverman, Maryellen R. M. Sun, Kemal Tuncali, Paul R. Morrison, Eric van Sonnenberg, Sridhar Shankar, Kelly H. Zou, Simon K. Warfield, "Three-Dimensional Assessment of MRI-Guided Percutatneous Cryotherapy of Liver Metastases, American Journal of Roentgenology. R.Nakamura, K.Tuncali, P.R.Morrison, N.Hata, S.G.Silverman, R.Kikinis, F.A.Jolesz, G.P.Zientara, "Control System for MR-Guided Cryotherapy - Short-Term Prediction of Therapy Boundary Using Automatic Segmentation and 3D Optical Flow", Lecture Notes in Computer Science (Springer-Verlag, Heidelberg), 7th Intl Conf. Medical Image Computing and Computer-Assisted Intervention MICCAI, Saint-Malo France, Sept 2004, Vol. 3217, Pt. II, pp.542-550. D.Mitsouras, W.S.Hoge, F.J.Rybicki, A.Edelman, G.P.Zientara, " Non-Fourier Encoded Parallel MRI Using Multiple Receiver Coils", Magn Res Med, 52:321-328, 2004. Abstracts Kemal Tuncali, Gary P Zientara, Ryoichi Nakamura, Paul R Morrison, Simon K Warfield, Stuart G Silverman, 3D Computerized Monitoring of MRI-guided Percutaneous Cryoablations: Validation of the System in an Animal Model and Retrospective Clinical Case Applications, Abstract for Radiological Society of North America's 91st Scientific Assembly and Annual Meeting, Chicago, Illinois, November 2005. K Tuncali, R Nakamura, EN Wildenberg, PR Morrison, SK Warfield, GP Zientara, SG Silverman, "3D Computerized Monitoring of Image-Guided Percutaneous Tumor Ablations: Validation of the System in an Animal Model and Retrospective Clinical Case Applications", Abstract for the 5th Interventional MRI Symposium, Boston, MA, October 2004. D. Mitsouras, R.V. Mulkern, A.S. Edelman, G.P.Zientara, F.J.Rybicki, "3D Ultra-Fast Spin Echo Inner Volume MRI: Neuroimaging Applications", Abstract for 12th Meeting Intl Society of Magnetic Resonance, Kyoto, Japan, May 2004. D Mitsouras , R V Mulkern, A Edelman, G P Zientara, F J Rybicki, "Neuroimaging Applications of Tow Reduced Field of View 3D Fast Spin Echo Magnetic Resonance Imaging Methods with Ultrashort, Non-Selective, Hard-Pulse Refocusing Radiofrequency Pulses", Abstract for Radiological Society of North America's 90th Scientific Assembly and Annual Meeting, Chicago, Illinois, November 2004.