Transcostal High Intensity Focused Ultrasound for the Treatment of Cancer

经肋高强度聚焦超声治疗癌症

• 批准号: EP/F025750/1
• 负责人: Nader Saffari
• 金额: $ 193.33万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FF025750%2F1
• 关键词: Transcostal; Intensity; Focused; Ultrasound; Treatment

The efficacy of high intensity focused ultrasound (HIFU) for the non-invasive treatment of cancer has been clearly demonstrated for a range of different cancers including those of the liver, prostate and breast. As a non-invasive focal therapy, HIFU offers considerable advantages over other techniques such as chemotherapy and surgery, in terms of invasiveness and risk of harmful side-effects. Despite its advantages, however, there are a number of significant challenges currently hindering its widespread clinical application, specifically: the need to transmit energy through the rib cage and the associated risk of skin burns and damage to the rib surface, the effects of organ motion on treatment accuracy, a poor understanding of cavitation processes in vivo and, finally, the lack of effective techniques for real-time image guidance and treatment monitoring. The overall objective of the research programme described in this document is to develop practical solutions for these issues. Successful completion of this proposal will result in a prototype clinical device for the safe and effective HIFU treatment of tumours of the liver, kidney and pancreas that has undergone preclinical testing and conforms to the necessary safety standards for patient use.

高强度聚焦超声（HIFU）用于癌症非侵入性治疗的疗效已在一系列不同癌症（包括肝癌、前列腺癌和乳腺癌）中得到明确证明。作为一种非侵入性的局部治疗，HIFU在侵入性和有害副作用的风险方面比其他技术如化疗和手术提供了相当大的优势。然而，尽管其具有优势，但目前仍存在许多重大挑战阻碍其广泛的临床应用，具体而言：需要通过胸腔传输能量以及皮肤烧伤和肋骨表面损伤的相关风险、器官运动对治疗精度的影响、对体内空化过程的不了解，最后，缺乏有效的实时图像引导和治疗监测技术。本文件所述研究方案的总体目标是为这些问题制定切实可行的解决办法。该提案的成功完成将产生一种用于安全有效地HIFU治疗肝、肾和胰腺肿瘤的原型临床器械，该器械已经过临床前测试，并符合患者使用的必要安全标准。

项目成果

Interactive planning of miniplates

• DOI: 10.1117/12.2249748
• 发表时间: 2017-03
• 作者: Markus Gall;K. Reinbacher;J. Wallner;Jan Stanzel;Xiaojun Chen;K. Schwenzer-Zimmerer;D. Schmalstieg;J. Egger

An assessment of the DORT method on simple scatterers using boundary element modelling.

使用边界元建模对简单散射体的 DORT 方法进行评估。

• DOI: 10.1088/0031-9155/60/9/3715
• 发表时间: 2015
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Gélat P

The NifTK software platform for image-guided interventions: platform overview and NiftyLink messaging

• DOI: 10.1007/s11548-014-1124-7
• 发表时间: 2015-03-01
• 期刊: INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
• 影响因子: 3
• 作者: Clarkson, Matthew J.;Zombori, Gergely;Ourselin, Sebastien
• 通讯作者: Ourselin, Sebastien

Towards the optimisation of acoustic fields for ablative therapies of tumours in the upper abdomen

优化上腹部肿瘤消融治疗的声场

• DOI: 10.1088/1742-6596/457/1/012002
• 发表时间: 2013
• 期刊: Conference Series
• 作者: Gélat P

Scattering of the field of a multi-element phased array by human ribs

人体肋骨对多元件相控阵场的散射

• DOI: 10.1088/1742-6596/353/1/012010
• 发表时间: 2012
• 期刊: Conference Series
• 作者: Gélat P