PILOT PROJECTS 8A, 8B AND 8C
试点项目 8A、8B 和 8C
基本信息
- 批准号:7469491
- 负责人:
- 金额:$ 9.76万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-07-01 至 2011-06-30
- 项目状态:已结题
- 来源:
- 关键词:AbstinenceAffectAgeAlcoholsAnatomyAnimalsAnteriorAreaBehavioralBrainBrain regionBudgetsCaffeineCell NucleusClinicalCognitionCognitiveCognitive deficitsDataDependenceDiagnostic and Statistical ManualDorsalDrug abuseExclusion CriteriaFunctional Magnetic Resonance ImagingFundingGeneticGlobus PallidusGoalsHistamineImpulsivityLong-Term EffectsMagnetic Resonance ImagingMeasuresMedialMediatingMedical centerMemory impairmentMethamphetamineModelingMusNeonatalNeuroanatomyNeurobiologyNicotineNumbersPatientsPerformancePharmaceutical PreparationsPilot ProjectsPreclinical Drug EvaluationProceduresProspective StudiesRecommendationRecoveryRelative (related person)ResearchResearch ActivityResearch PersonnelResearch Project GrantsResourcesSelf AdministrationShort-Term MemorySignal TransductionSubstantia nigra structureSystemTask PerformancesThalamic structureTimeTranslational ResearchUrineVentral Tegmental AreaWeekWorkaddictionbasedaydesigndiscountdiscountingfrontal lobeimprovedinnovationinsightmembermethamphetamine exposureneural circuitneuroadaptationneuroimagingpre-clinicalrelating to nervous systemstressor
项目摘要
The Pilot Project Component is designed to provide a flexible means for developing and exploring new
research activities or directions, and unique opportunities that can evolve into independently funded
research projects. In addition, the Pilot Project Component provides a resource for attracting new
investigators into drug abuse research. We propose to fund an average of three pilot projects per year with
an average budget of $33K. The expected duration of these pilot projects will be 1-2 years. The Center
Scientific Director will manage this Component. Pilot Project Component applications will be solicited from all
OHSU- and Portland VA Medical Center-based investigators annually. Each proposal will be evaluated for
scientific merit/innovation, thematic alignment and several other criteria by at least two members of the
Center's Scientific Advisory Board, the Scientific Director, and the Center Director. Recommendations for
funding will be considered for approval by the Center Executive Committee. Three pilot projects are
proposed for funding in Year 1 of the Methamphetamine Abuse Research Center (MARC). Project 8A (W.
Hoffman, PI) will use functional magnetic resonance imaging to study neuroanatomical associates of MA
addiction and heightened impulsivity. Project 8B (S. Mitchell, PI) will examine in mice the notion that
impulsivity is related to MA self-administration, using a delay discounting procedure. Project 8C (J. Raber,
PI) will explore the hypothesis that histamine mediates the detrimental long-term effects of neonatal MA
exposure on cognition. All of these pilots are related to a Center theme at least by virtue of their examination
of MA effects. In addition, mice used in Project 8B and 8C will share genetic background with those used in
Scientific Components 5 and 6, and will obtain mice from the Animal Core. Pilot project 8A also relates to the
Center impulsivity, neuroadaptation and neuroanatomy themes; Pilot project 8B relates to the Center
impulsivity theme; and Pilot project 8C relates to the Center stressor responsivity and neuroadaptation
themes. It is expected that Pilot Component projects funded in years 2-5 of the Center will contribute to the
study of MA abuse and to one or more of the additional themes of the Center: Impulsivity, stressor
responsivity, neuroadaptation, and neuroanatomy, and to our goal of pursuing translational research in
preclinical and clinical models.
试点项目组件旨在提供一种灵活的方法来开发和探索新的
研究活动或方向,以及可演变为独立资助的独特机会
研究项目。此外,试点项目部分还提供了吸引新的
对药物滥用研究的调查。我们建议平均每年资助三项试验计划,包括
平均预算为3.3万美元。这些试点项目的预计期限为1-2年。《中心》
科学主任将管理这一部分。试点项目组件申请将向所有
每年在俄亥俄州立大学和波特兰退伍军人医学中心工作的调查人员。将对每项提案进行评估
科学功绩/创新、主题协调和若干其他标准,由至少两名
中心的科学顾问委员会、科学主任和中心主任。针对以下方面的建议
资金将考虑由中心执行委员会批准。三个试点项目是
建议在甲基苯丙胺滥用研究中心(MARC)的第一年提供资金。项目8A(W.
Hoffman,Pi)将使用功能磁共振成像来研究MA的神经解剖学联系
上瘾和高度冲动。项目8B(S.Mitchell,Pi)将在小鼠身上检验
冲动性与MA自我管理有关,使用延迟贴现程序。项目8C(J.Raber,
PI)将探索组胺介导新生儿MA有害长期影响的假设
暴露在认知上。所有这些飞行员都与一个中心主题有关,至少从他们的检查来看是这样
MA效应的影响。此外,项目8B和8C中使用的小鼠将与项目8B和8C中使用的小鼠具有相同的遗传背景
科学组件5和6,并将从动物核心获得小鼠。试验计划8A亦涉及
中心冲动、神经适应和神经解剖学主题;试点项目8B与中心有关
冲动主题;试点项目8C与中心应激源反应性和神经适应有关
主题。预计在中心第2-5年资助的试点组成部分项目将有助于
对MA滥用的研究以及中心的一个或多个附加主题:冲动、压力源
响应性、神经适应和神经解剖学,以及我们追求翻译研究的目标
临床前和临床模型。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('TAMARA J. RICHARDS', 18)}}的其他基金
BLRD Research Career Scientist Award Application
BLRD 研究职业科学家奖申请
- 批准号:
10696821 - 财政年份:2023
- 资助金额:
$ 9.76万 - 项目类别:
Genetic Factors Underlying Risk for Methamphetamine Intake and Associated Traits
甲基苯丙胺摄入风险和相关特征的遗传因素
- 批准号:
10448448 - 财政年份:2018
- 资助金额:
$ 9.76万 - 项目类别:
Genetic Factors Underlying Risk for Methamphetamine Intake and Associated Traits
甲基苯丙胺摄入风险和相关特征的遗传因素
- 批准号:
9977141 - 财政年份:2018
- 资助金额:
$ 9.76万 - 项目类别:
Genetic Factors Underlying Risk for Methamphetamine Intake and Associated Traits
甲基苯丙胺摄入风险和相关特征的遗传因素
- 批准号:
10215457 - 财政年份:2018
- 资助金额:
$ 9.76万 - 项目类别:
Genetic basis and mechanisms underlying binge-level methamphetamine intake
暴食水平甲基苯丙胺摄入的遗传基础和机制
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10427124 - 财政年份:2014
- 资助金额:
$ 9.76万 - 项目类别:
Genetic basis and mechanisms underlying binge-level methamphetamine intake
暴食水平甲基苯丙胺摄入的遗传基础和机制
- 批准号:
10082416 - 财政年份:2014
- 资助金额:
$ 9.76万 - 项目类别:
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