PILOT PROJECTS 8A, 8B AND 8C

试点项目 8A、8B 和 8C

• 批准号: 7657308
• 负责人: TAMARA J. RICHARDS
• 金额: $ 9.75万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7657308
• 关键词: Abstinence; Affect; Age; Alcohols; Anatomy; Animals; Anterior; Area; Behavioral; Brain; Brain region; Budgets; Caffeine; Cell Nucleus; Clinical; Cognition; Cognitive; Cognitive deficits; Data; Dependence; Diagnostic and Statistical Manual; Dorsal; Drug abuse; Exclusion Criteria; Functional Magnetic Resonance Imaging; Funding; Genetic; Globus Pallidus; Goals; Histamine; Impulsivity; Long-Term Effects; Magnetic Resonance Imaging; Measures; Medial; Mediating; Medical center; Memory impairment; Methamphetamine; Modeling; Mus; Neonatal; Neuroanatomy; Neurobiology; Nicotine; Numbers; Patients; Performance; Pharmaceutical Preparations; Pilot Projects; Preclinical Drug Evaluation; Procedures; Prospective Studies; Recommendation; Recovery; Relative (related person); Research; Research Activity; Research Personnel; Research Project Grants; Resources; Self Administration; Short-Term Memory; Signal Transduction; Substantia nigra structure; System; Task Performances; Thalamic structure; Time; Translational Research; Urine; Ventral Tegmental Area; Week; Work; addiction; base; day; design; discount; discounting; frontal lobe; improved; innovation; insight; member; methamphetamine exposure; neural circuit; neuroadaptation; neuroimaging; pre-clinical; relating to nervous system; stressor

The Pilot Project Component is designed to provide a flexible means for developing and exploring new research activities or directions, and unique opportunities that can evolve into independently funded research projects. In addition, the Pilot Project Component provides a resource for attracting new investigators into drug abuse research. We propose to fund an average of three pilot projects per year with an average budget of $33K. The expected duration of these pilot projects will be 1-2 years. The Center Scientific Director will manage this Component. Pilot Project Component applications will be solicited from all OHSU- and Portland VA Medical Center-based investigators annually. Each proposal will be evaluated for scientific merit/innovation, thematic alignment and several other criteria by at least two members of the Center's Scientific Advisory Board, the Scientific Director, and the Center Director. Recommendations for funding will be considered for approval by the Center Executive Committee. Three pilot projects are proposed for funding in Year 1 of the Methamphetamine Abuse Research Center (MARC). Project 8A (W. Hoffman, PI) will use functional magnetic resonance imaging to study neuroanatomical associates of MA addiction and heightened impulsivity. Project 8B (S. Mitchell, PI) will examine in mice the notion that impulsivity is related to MA self-administration, using a delay discounting procedure. Project 8C (J. Raber, PI) will explore the hypothesis that histamine mediates the detrimental long-term effects of neonatal MA exposure on cognition. All of these pilots are related to a Center theme at least by virtue of their examination of MA effects. In addition, mice used in Project 8B and 8C will share genetic background with those used in Scientific Components 5 and 6, and will obtain mice from the Animal Core. Pilot project 8A also relates to the Center impulsivity, neuroadaptation and neuroanatomy themes; Pilot project 8B relates to the Center impulsivity theme; and Pilot project 8C relates to the Center stressor responsivity and neuroadaptation themes. It is expected that Pilot Component projects funded in years 2-5 of the Center will contribute to the study of MA abuse and to one or more of the additional themes of the Center: Impulsivity, stressor responsivity, neuroadaptation, and neuroanatomy, and to our goal of pursuing translational research in preclinical and clinical models.

试点项目组件旨在为开发和探索新的项目提供灵活的方法