PILOT PROJECTS 8A, 8B AND 8C

试点项目部分旨在为开发和探索新的 研究活动或方向，以及可以发展成为独立资助的独特机会 研究项目。此外，试点项目部分还为吸引新的 药物滥用研究的调查员我们建议每年平均资助三项试验计划， 平均预算为3.3万美元。这些试点项目的预期期限为1-2年。中心 科学总监将管理该组件。试点项目组成部分的申请将征求所有 OHSU和波特兰VA医学中心的研究者每年。每一份提案都将被评估， 科学价值/创新、主题一致性和其他一些标准，至少有两名委员会成员提出 中心的科学顾问委员会，科学主任和中心主任。建议 资金将由中心执行委员会审议批准。三个试点项目是 在第一年的甲基苯丙胺滥用研究中心（MARC）的资金建议。项目8A（W. 霍夫曼，PI）将使用功能磁共振成像研究MA的神经解剖学相关 上瘾和冲动项目8B（S. Mitchell，PI）将在小鼠中检查以下概念： 冲动与MA自我管理有关，使用延迟折扣程序。项目8 C（J. Raber， PI）将探讨组胺介导新生儿MA的有害长期影响的假设 认知上的暴露。所有这些试点都与一个中心的主题有关，至少通过他们的检查 MA的影响。此外，项目8B和8 C中使用的小鼠将与项目8B和8 C中使用的小鼠共享遗传背景。 科学组件5和6，并将从动物中心获得小鼠。试点项目8A还涉及 中心冲动性、神经适应性和神经解剖学主题;试点项目8B与中心有关 冲动性主题;试点项目8 C涉及中心的应激源反应和神经适应 主题.预计中心第2-5年资助的试点项目将有助于 MA滥用的研究和该中心的一个或多个额外的主题：冲动，压力源 反应性，神经适应性和神经解剖学，以及我们追求转化研究的目标， 临床前和临床模型。

The Pilot Project Component is designed to provide a flexible means for developing and exploring new research activities or directions, and unique opportunities that can evolve into independently funded research projects. In addition, the Pilot Project Component provides a resource for attracting new investigators into drug abuse research. We propose to fund an average of three pilot projects per year with an average budget of $33K. The expected duration of these pilot projects will be 1-2 years. The Center Scientific Director will manage this Component. Pilot Project Component applications will be solicited from all OHSU- and Portland VA Medical Center-based investigators annually. Each proposal will be evaluated for scientific merit/innovation, thematic alignment and several other criteria by at least two members of the Center's Scientific Advisory Board, the Scientific Director, and the Center Director. Recommendations for funding will be considered for approval by the Center Executive Committee. Three pilot projects are proposed for funding in Year 1 of the Methamphetamine Abuse Research Center (MARC). Project 8A (W. Hoffman, PI) will use functional magnetic resonance imaging to study neuroanatomical associates of MA addiction and heightened impulsivity. Project 8B (S. Mitchell, PI) will examine in mice the notion that impulsivity is related to MA self-administration, using a delay discounting procedure. Project 8C (J. Raber, PI) will explore the hypothesis that histamine mediates the detrimental long-term effects of neonatal MA exposure on cognition. All of these pilots are related to a Center theme at least by virtue of their examination of MA effects. In addition, mice used in Project 8B and 8C will share genetic background with those used in Scientific Components 5 and 6, and will obtain mice from the Animal Core. Pilot project 8A also relates to the Center impulsivity, neuroadaptation and neuroanatomy themes; Pilot project 8B relates to the Center impulsivity theme; and Pilot project 8C relates to the Center stressor responsivity and neuroadaptation themes. It is expected that Pilot Component projects funded in years 2-5 of the Center will contribute to the study of MA abuse and to one or more of the additional themes of the Center: Impulsivity, stressor responsivity, neuroadaptation, and neuroanatomy, and to our goal of pursuing translational research in preclinical and clinical models.