CORE--IMAGING

NIDA中心的成像核心旨在为分子成像研究提供完全集成和全面的支持。成像核心还将包括旨在为试点项目提供新机会的开发组件，或增强PET成像的当前数据采集能力。成像核心的协调要素将包括正电子发射断层扫描（PET）成像、计算机建模、数据分析和放射化学。成像核心将为NIDA中心授予的个别项目提供专门的分子成像工具。核心项目将提供一种机制，将几名年轻的研究人员纳入该中心的资助，并为制定未来的试点项目提供基础设施。此外，成像核心将允许

The Imaging Core into the NIDA Center is intended to provide fully-integrated and comprehensive support for molecular imaging research. The Imaging Core will also include developmental components intended to provide new opportunities for pilot projects, or enhance the current capability of data acquisition by PET imaging. The coordinated elements of the Imaging Core will include positron emission tomography (PET) imaging, computer modeling, data analysis and radiochemistry. The Imaging Core will provide specialized molecular imaging tools for specific research addressed in several of the NIDA Center grant individual projects. The Core will provide a mechanism for the inclusion of several young investigators into the Center grant, as well as an infrastructure for developing future pilot projects. Moreover, the Imaging Core will allow the Center Grant to expand upon the successful development, through a previous Center funded pilot project, of the selective and high affinity dopamine transporter (DAT) radioligand, [18F]-(+)-N-(4-fluorobenzyl)- 2beta-propanoyl-3beta-(4-chlorophenyl) tropane ([18F]FCT). The Imaging Core will consist of three synergistic components: Data Analysis Component: This component will be responsible for all image data analysis, including kinetic/computer modeling, and comprehensive data and statistical analysis for Project PET scans. In addition, kinetic and computer modeling strategies will be developed for the use of new radiopharmaceuticals utilized by the projects or generated by the Imaging Core. Imaqing Component: This component will provide the necessary personnel and infrastructure to conduct the PET scans included with various Projects. The support will be comprehensive including veterinary management, PET camera technology, metabolite analysis of biological specimens, kinetic/computer modeling, data and statistical analysis, quality assurance, and assistance in manuscript, presentations, and proposals. The Imaging Component will also have a developmental component to validate and refine the quantitative techniques for MicroPET. Radiochemistry Component This component will be to carry out synthesis and production of both routine ("off-the-shelf") and custom radioligands and to make these radioligands available for both the base and pilot projects of the Center as required