CORE--IMAGING

进入NIDA中心的成像核心旨在为分子成像研究提供完全集成的全面支持。成像核心还将包括开发部分，旨在为试点项目提供新的机会，或增强目前通过正电子发射计算机断层扫描获取数据的能力。成像核心的协调要素将包括正电子发射断层成像(PET)、计算机建模、数据分析和放射化学。成像核心将为NIDA中心资助的几个单独项目中涉及的特定研究提供专门的分子成像工具。该核心将提供一种机制，以便将几名年轻的调查人员纳入中心赠款，并为发展未来的试点项目提供基础设施。此外，成像核心将允许 该中心通过之前中心资助的试点项目，成功开发了选择性和高亲和力的多巴胺转运体(DAT)放射性配体[18F]-()-N-(4-氟苯基)-2-β-丙酰基-3-(4-氯苯基)托烷([18F]FCT)。成像核心将由三个协同组件组成： 数据分析组件：该组件将负责所有图像数据分析，包括动力学/计算机建模，以及项目PET扫描的综合数据和统计分析。此外，还将为项目利用或成像核心产生的新放射性药物的使用制定动力学和计算机模拟战略。 伊玛清组件：该组件将提供必要的人员和基础设施，以进行各种项目附带的正电子发射计算机断层扫描。支持将是全面的，包括兽医管理、PET摄像技术、生物标本的代谢物分析、动力学/计算机建模、数据和统计分析、质量保证以及手稿、演示文稿和提案方面的协助。成像部分还将有一个开发部分，用于验证和改进微型PET的定量技术。 放射化学部分该部分将进行常规(“现成”)和定制放射性配体的合成和生产，并根据需要为中心的基础和试点项目提供这些放射性配体

The Imaging Core into the NIDA Center is intended to provide fully-integrated and comprehensive support for molecular imaging research. The Imaging Core will also include developmental components intended to provide new opportunities for pilot projects, or enhance the current capability of data acquisition by PET imaging. The coordinated elements of the Imaging Core will include positron emission tomography (PET) imaging, computer modeling, data analysis and radiochemistry. The Imaging Core will provide specialized molecular imaging tools for specific research addressed in several of the NIDA Center grant individual projects. The Core will provide a mechanism for the inclusion of several young investigators into the Center grant, as well as an infrastructure for developing future pilot projects. Moreover, the Imaging Core will allow the Center Grant to expand upon the successful development, through a previous Center funded pilot project, of the selective and high affinity dopamine transporter (DAT) radioligand, [18F]-(+)-N-(4-fluorobenzyl)- 2beta-propanoyl-3beta-(4-chlorophenyl) tropane ([18F]FCT). The Imaging Core will consist of three synergistic components: Data Analysis Component: This component will be responsible for all image data analysis, including kinetic/computer modeling, and comprehensive data and statistical analysis for Project PET scans. In addition, kinetic and computer modeling strategies will be developed for the use of new radiopharmaceuticals utilized by the projects or generated by the Imaging Core. Imaqing Component: This component will provide the necessary personnel and infrastructure to conduct the PET scans included with various Projects. The support will be comprehensive including veterinary management, PET camera technology, metabolite analysis of biological specimens, kinetic/computer modeling, data and statistical analysis, quality assurance, and assistance in manuscript, presentations, and proposals. The Imaging Component will also have a developmental component to validate and refine the quantitative techniques for MicroPET. Radiochemistry Component This component will be to carry out synthesis and production of both routine ("off-the-shelf") and custom radioligands and to make these radioligands available for both the base and pilot projects of the Center as required