CORE--IMAGING

核心--成像

• 批准号: 7390849
• 负责人: Kathryn Ann Morton
• 金额: $ 15.43万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7390849
• 关键词: Abstinence; Address; Affinity; Binding; Biodistribution; Biogenic Amines; Biological; Biological Assay; Blood - brain barrier anatomy; Blood specimen; Brain; Carbon; Characteristics; Chemistry; Cocaine; Cocaine Dependence; Computer Simulation; Computer software; Computers; Custom; Data; Data Analyses; Deoxyglucose; Development; Elements; Equipment; Evaluation; Fluorine; Funding; Future; Goals; Grant; High Pressure Liquid Chromatography; Human Resources; Image; Image Analysis; Imaging Device; In Vitro; Individual; Kinetics; Label; Ligands; Macaca mulatta; Manuscripts; Measurement; Measures; Metabolic; Methods; Mission; Modeling; Monkeys; National Institute of Drug Abuse; Numbers; Penetration; Pharmaceutical Preparations; Pilot Projects; Positron-Emission Tomography; Preparation; Primates; Principal Investigator; Production; Protocols documentation; Publishing; Radiochemistry; Radiolabeled; Radiopharmaceuticals; Rattus; Reference Standards; Research; Research Infrastructure; Research Personnel; Resolution; Ritalin; Rodent; Sampling; Scanning; Sedation procedure; Self Administration; Serotonin; Services; Solutions; Specimen; Statistical Data Interpretation; Structure; Support of Research; Synaptosomes; Techniques; Technology; Therapeutic Intervention; Tracer; Tropanes; Tryptamines; Validation; addiction; analog; base; data acquisition; data modeling; design; digital imaging; dopamine transporter; in vivo; inhibitor/antagonist; interest; microsystems; molecular imaging; nonhuman primate; noradrenaline transporter; novel; programs; quality assurance; radioligand; radiotracer; receptor; research study; response; serotonin transporter; tool; tryptamine; uptake

The Imaging Core into the NIDA Center is intended to provide fully-integrated and comprehensive support for molecular imaging research. The Imaging Core will also include developmental components intended to provide new opportunities for pilot projects, or enhance the current capability of data acquisition by PET imaging. The coordinated elements of the Imaging Core will include positron emission tomography (PET) imaging, computer modeling, data analysis and radiochemistry. The Imaging Core will provide specialized molecular imaging tools for specific research addressed in several of the NIDA Center grant individual projects. The Core will provide a mechanism for the inclusion of several young investigators into the Center grant, as well as an infrastructure for developing future pilot projects. Moreover, the Imaging Core will allow the Center Grant to expand upon the successful development, through a previous Center funded pilot project, of the selective and high affinity dopamine transporter (DAT) radioligand, [18F]-(+)-N-(4-fluorobenzyl)- 2beta-propanoyl-3beta-(4-chlorophenyl) tropane ([18F]FCT). The Imaging Core will consist of three synergistic components: Data Analysis Component: This component will be responsible for all image data analysis, including kinetic/computer modeling, and comprehensive data and statistical analysis for Project PET scans. In addition, kinetic and computer modeling strategies will be developed for the use of new radiopharmaceuticals utilized by the projects or generated by the Imaging Core. Imaqing Component: This component will provide the necessary personnel and infrastructure to conduct the PET scans included with various Projects. The support will be comprehensive including veterinary management, PET camera technology, metabolite analysis of biological specimens, kinetic/computer modeling, data and statistical analysis, quality assurance, and assistance in manuscript, presentations, and proposals. The Imaging Component will also have a developmental component to validate and refine the quantitative techniques for MicroPET. Radiochemistry Component This component will be to carry out synthesis and production of both routine ("off-the-shelf") and custom radioligands and to make these radioligands available for both the base and pilot projects of the Center as required

NIDA中心的成像核心旨在为分子成像研究提供完全集成和全面的支持。成像核心还将包括开发组件，旨在为试点项目提供新的机会，或增强目前通过PET成像获取数据的能力。成像核心的协调要素将包括正电子发射断层扫描（PET）成像、计算机建模、数据分析和放射化学。成像核心将提供专门的分子成像工具，用于NIDA中心资助的几个项目中的特定研究。核心基金将提供一种机制，将几名年轻的研究人员纳入中心赠款，并为开发未来的试点项目提供基础设施。此外，成像核心将允许 通过先前中心资助的试点项目，在成功开发选择性和高亲和力多巴胺转运蛋白（DAT）放射性配体[18 F]-（+）-N-（4-氟苄基）-2 β-丙酰基-3 β-（4-氯苯基）托烷（[18 F]FCT）的基础上，扩大中心赠款。成像核心将由三个协同组件组成： 数据分析组件：该组件将负责所有图像数据分析，包括动力学/计算机建模，以及项目PET扫描的综合数据和统计分析。此外，还将开发动力学和计算机建模策略，以使用项目使用或成像核心生成的新放射性药物。 Imaqing组件：该组件将提供必要的人员和基础设施，以进行各种项目中包含的PET扫描。支持将是全面的，包括兽医管理，PET相机技术，生物标本的代谢物分析，动力学/计算机建模，数据和统计分析，质量保证，并在手稿，演示文稿和建议的援助。成像组件还将有一个开发组件，以验证和完善MicroPET的定量技术。 放射化学部分该部分将进行常规（“现成”）和定制放射性配体的合成和生产，并根据需要为中心的基础和试点项目提供这些放射性配体。