权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

A new fibre optic intravascular oxygen sensor for measuring fast and dynamic arterial blood oxygen tension changes online

一种新型光纤血管内氧传感器，用于在线快速动态测量动脉血氧张力变化

基本信息

批准号：
EP/F02987X/1
负责人：
Clive Edward Winston Hahn
金额：
$ 29.17万
依托单位：
University of Oxford
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2008
资助国家：
英国
起止时间：
2008 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FF02987X%2F1
关键词：
new fibre optic intravascular oxygen

项目摘要

We have demonstrated, in the diseased lung, using a prototype intravascular electrochemical oxygen sensor, that lung alveolar units begin to collapse in expiration and re-open in inspiration, and that process ( known as cyclical atelactasis) causes the oxygen partial pressure in the arterial blood (PaO2) to oscillate widely on a breath-by-breath basis. These results have been confirmed independently by international investigators. However, the prototype oxygen sensors used by ourselves and others were unable to measure rapid PaO2 oscillations in flowing blood accurately, especially when the oxyhaemoglobin (the red pigmant in blood) saturation was changing. We now need to adapt and further develop a brand new intravascular sensor, using new technology, to measure these fast blood oxygen oscillations independent of oxyhaemoglobin saturation.It is also well established that the application of mechanical ventilation to hospital patients in Intensive Care Units exacerbates this repetitive atelactasis process and can cause further mechanical lung damage, known as Ventilator Induced Lung Injury (VILI). There is an international quest to understand the mechanisms underlying VILI and to reduce its incidence, and to reduce the deleterious effects of atelactasis on the lung.We believe, along with other workers, that the presence of PaO2 oscillations in arterial blood can be used (a) to detect the onset of cyclical atelactasis in the lung; and (b) also to direct the clinician to adjust the ventilator settings to reduce the amplitude of the oscillations / and thus reduce or else eliminate the atelactasis process itself.A clinical need therefore exists for a rapid-response intravascular oxygen sensor to measure these intrabreath PaO2 oscillations on-line and in real time. Currently available clinical intravascular oxygen sensors are, far too slow (60-90 sec time response) to be used for this breath-by-breath clinical measurement. Therefore a new fast response oxygen sensor must be developed, and that is the reason for this biomedical engineering grant application. The work will concentrate on developing this new sensor and testing it in the laboratory, before it is ultimately tested in physiological conditions (in vivo). The new sensor, based on a fibre optic technique, will enable measurements to be made in critically-ill patients in the Intensive Care Unit, in order to moderate the incidence and severity of VILI.

我们已经证明，在患病的肺中，使用原型血管内电化学氧传感器，肺泡单元开始在呼气时塌陷并在吸气时重新开放，并且该过程（称为周期性肺不张）导致动脉血中的氧分压（PaO 2）在呼吸基础上广泛振荡。这些结果已得到国际调查人员的独立证实。然而，我们和其他人使用的原型氧传感器无法准确测量流动血液中的快速PaO 2振荡，特别是当氧合血红蛋白（血液中的红色色素）饱和度发生变化时。我们现在需要适应和进一步开发一种全新的血管内传感器，使用新技术，来测量这些快速的血氧振荡，而不依赖于氧合血红蛋白饱和度。这也是公认的，机械通气的应用，医院重症监护病房的病人加剧了这种重复性的肺不张的过程，并可能导致进一步的机械性肺损伤，称为呼吸机诱导的肺损伤（VILI）。国际上一直在寻求了解VILI的潜在机制，降低其发病率，并减少肺不张对肺的有害影响。我们与其他工作者沿着认为，动脉血中PaO 2振荡的存在可用于（a）检测肺中周期性肺不张的发作;以及（B）还指导临床医生调节呼吸机设置以减小振荡的幅度，从而减小或消除乳糖不全过程本身。响应血管内氧传感器以在线和真实的时间测量这些呼吸内PaO 2振荡。目前可用的临床血管内氧传感器太慢（60-90秒时间响应）而不能用于这种逐呼吸的临床测量。因此，必须开发一种新的快速响应氧传感器，这就是申请生物医学工程资助的原因。这项工作将集中在开发这种新的传感器，并在实验室中进行测试，然后在生理条件下（体内）进行最终测试。新的传感器，基于光纤技术，将使测量在重症监护室的危重病人，以缓和VILI的发病率和严重程度。