Chlamydia-infected Epithelial Cell Secretion of Immunoregulatory Cytokines

衣原体感染的上皮细胞分泌免疫调节细胞因子

• 批准号: 7470141
• 负责人: WILBERT A DERBIGNY
• 金额: $ 10.8万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7470141
• 关键词: Acute; Agonist; Arum; CXCL10 gene; CXCL9 gene; Cell Line; Cell secretion; Cells; Chlamydia; Chlamydia Infections; Chlamydia trachomatis; Data; Dendritic Cells; Developed Countries; Developing Countries; Dominant-Negative Mutation; Epithelial Cells; Event; Exhibits; Genes; Genital system; Goals; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic; Host Defense; Human; Immune; Immune response; Infection; Inflammatory; Integration Host Factors; Interferon-beta; Interferons; Interleukin-12; Interleukin-6; Knockout Mice; Knowledge; Mammalian Oviducts; Messenger RNA; Modeling; Molecular; Mus; Outcome; Pattern Recognition; Play; Poly I-C; Production; Proteins; Publishing; Recruitment Activity; Regulation; Regulatory Pathway; Reproductive Tract Infections; Research; Research Personnel; Role; Sexually Transmitted Diseases; Signal Pathway; Smooth Muscle Myocytes; Surface; TLR2 gene; TLR3 gene; TLR4 gene; Testing; abstracting; autocrine; cell type; chemokine; cytokine; extracellular; genital infection; interleukin-12 subunit p35; keratinocyte; knockout animal; macrophage; monocyte; mouse model; neutralizing antibody; paracrine; pathogen; programs; receptor; reproductive; research study; respiratory smooth muscle; response; tool

DESCRIPTION (provided by applicant): NO ABSTRACT WAS PROVIDED BY THE PI.

描述（由申请人提供）：PI未提供摘要。

项目成果

Analyses of the pathways involved in early- and late-phase induction of IFN-beta during C. muridarum infection of oviduct epithelial cells.

• DOI: 10.1371/journal.pone.0119235
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Hu S;Hosey KL;Derbigny WA
• 通讯作者: Derbigny WA