Investigating mechanisms underpinning outcomes in people on opioid agonist treatment for OUD: Disentangling sleep and circadian rhythm influences on craving and emotion regulation
研究阿片类激动剂治疗 OUD 患者结果的机制:解开睡眠和昼夜节律对渴望和情绪调节的影响
基本信息
- 批准号:10784209
- 负责人:
- 金额:$ 118.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-30 至 2027-08-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAffectArchitectureBehaviorBuprenorphineCessation of lifeCharacteristicsCircadian DysregulationCircadian RhythmsCognitive TherapyDoseEcological momentary assessmentElectroencephalographyEmotionsFinancial costHumanIndividualInterventionLinkMeasuresMelatoninMethadoneMethodsMonitorMotivationNeurocognitiveOpioidOpioid agonistOutcomePathway interactionsPatientsPersonsPharmaceutical PreparationsPhasePhenotypePolysomnographyPopulationProtocols documentationQualitative MethodsRecoveryRelapseReportingResearchRisk FactorsScienceSiteSleepSleep ArchitectureSleep DisordersSleep disturbancesSleeplessnessSymptomsTreatment outcomeWorkactigraphyaddictionbiological sexcircadiancostcravingemotion regulationimprovedinsightmedication for opioid use disordernegative affectnovelopioid agonist therapyopioid epidemicopioid use disorderpoor sleeprelapse predictionsleep behaviorsleep patternsleep physiologysleep qualitysuccesstargeted treatmenttherapy designtherapy developmenttreatment adherence
项目摘要
Project Summary/Abstract
The US opioid epidemic costs over $1.5T and over 75,000 deaths annually. An understudied risk factor
for opioid use disorder (OUD) and its treatment is the importance of sleep and circadian rhythms (CR).
Opioids impact sleep quality in a fashion that inhibits recovery, and sleep remains a critical factor even when
patients enter treatment: the two most efficacious medications for OUD (MOUD) also cause sleep problems
that contribute to suboptimal outcomes. To address the enormous costs of the opioid epidemic, it is essential
to understand the mechanisms underlying the relationship between MOUD, poor sleep, and negative
outcomes. Thus, our central hypothesis is that examination of sleep and circadian phenotypes, will help to
identify individuals on MOUD who will benefit from specific interventions. Characterization of the bidirectional
interplay between sleep behaviors, sleep architecture, circadian rhythms, and neurocognitive measures in
individuals on MOUD is a crucial first step in identifying potential mechanisms or modifiable variables to
improve MOUD outcomes. Identifying the specific type of sleep/circadian disruption by MOUD may highlight
adjunctive treatment options to address the relevant sleep problem (e.g., cognitive behavioral therapy for
insomnia). Moreover, MOUDs disrupt sleep, but it is not known whether this is via alterations of CR or
alterations of sleep behavior/architecture. Sleep/CR science provides experimental methods for separating
circadian timing from sleep physiology in the form of the 90-minute day. Prior work highlights neurocognitive
phenotypes, craving and emotion regulation (ER), that are critical for successful MOUD outcomes. Cravings
are both an OUD symptom and frequent predictor of relapse. Sleep quality affects craving possibly through
positive and negative affect, emphasizing that ER is of critical concern with MOUD, as patients report an
inability to regulate emotions as a primary motivation for use and for relapse. Poor sleep is associated with
diminished ER. In 100 individuals on MOUD we will 1) evaluate (a) naturally occurring sleep patterns using
activity monitoring for one week and (b) sleep physiology through polysomnographic recording in the sleep lab
to contribute to the common aim across research sites and to provide descriptive analyses; 2) examine sleep
and circadian phenotypes using variables collected via actigraphy, PSG, and the 90-min day protocol to
examine associations of these phenotypes with neurocognitive mechanisms that may impact outcome of OUD
treatment including craving and emotion regulation; and 3) use qualitative methods to investigate the
acceptability, feasibility, and perceived utility of interventions targeting the specific mechanistic relationships
hypothesized. In summary, we plan a comprehensive examination of novel pathways between sleep/circadian
rhythms and neurocognitive factors —craving and emotion regulation—critical to success in MOUD as putative
mechanisms underpinning the association of poor sleep and suboptimal treatment outcomes.
项目摘要/摘要
美国的阿片类药物流行每年造成超过1.5T美元的损失和超过7.5万人的死亡。未被充分研究的风险因素
对于阿片使用障碍(OUD)及其治疗是睡眠和昼夜节律(CR)的重要性。
阿片类药物以抑制恢复的方式影响睡眠质量,而睡眠仍然是一个关键因素,即使在
患者接受治疗:两种最有效的药物也会导致睡眠问题
这导致了次优的结果。要解决阿片类药物流行的巨大代价,至关重要的是
了解多动症、睡眠不良和负性情绪之间关系的潜在机制
结果。因此,我们的中心假设是对睡眠和昼夜节律表型的检查将有助于
在Moud上确定将从特定干预中受益的个人。双向性的刻画
睡眠行为、睡眠结构、昼夜节律和神经认知测量之间的相互作用
Moud上的个人是确定潜在机制或可修改变量的关键第一步
改善Moud的结果。识别特定类型的睡眠/昼夜节律中断可能会突出显示
解决相关睡眠问题的辅助治疗选择(例如,认知行为治疗
失眠)。此外,霉菌会扰乱睡眠,但尚不清楚这是通过CR或CR的改变实现的
睡眠行为/结构的改变。睡眠/CR科学为分离提供了实验方法
昼夜节律来自睡眠生理学的90分钟一天的形式。先前的工作突出了神经认知
表型,渴望和情绪调节(ER),这是成功的Moud结果的关键。食欲
既是一种不良症状,也是复发的常见预测指标。睡眠质量可能通过以下途径影响渴望
积极和消极的影响,强调ER是Moud的关键问题,因为患者报告
不能将情绪调节作为使用和复发的主要动机。睡眠不佳与
减少ER。在Moud上的100个人中,我们将1)评估(A)自然发生的睡眠模式,使用
在睡眠实验室通过多导睡眠图记录进行一周的活动监测和(B)睡眠生理学
为跨研究站点的共同目标做出贡献,并提供描述性分析;2)检查睡眠
和昼夜节律表型,使用通过动作图、PSG和90分钟一天方案收集的变量来
检查这些表型与神经认知机制的关系,这些神经认知机制可能会影响OUD的结果
治疗包括渴求和情绪调节;3)采用定性的方法调查
针对特定机制关系的干预措施的可接受性、可行性和感知效用
假设的。总而言之,我们计划对睡眠/昼夜节律之间的新通路进行全面检查
节奏和神经认知因素-渴望和情绪调节-作为推测的穆德成功的关键
支持睡眠质量差和治疗效果不佳之间联系的机制。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Mary A Carskadon其他文献
Mary A Carskadon的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Mary A Carskadon', 18)}}的其他基金
COBRE Center for Sleep and Circadian Rhythms in Child and Adolescent Mental Health
COBRE 儿童和青少年心理健康睡眠和昼夜节律中心
- 批准号:
10594987 - 财政年份:2021
- 资助金额:
$ 118.41万 - 项目类别:
COBRE Center for Sleep and Circadian Rhythms in Child and Adolescent Mental Health
COBRE 儿童和青少年心理健康睡眠和昼夜节律中心
- 批准号:
10090146 - 财政年份:2021
- 资助金额:
$ 118.41万 - 项目类别:
COBRE Center for Sleep and Circadian Rhythms in Child and Adolescent Mental Health
COBRE 儿童和青少年心理健康睡眠和昼夜节律中心
- 批准号:
10385694 - 财政年份:2021
- 资助金额:
$ 118.41万 - 项目类别:
COBRE Center for Sleep and Circadian Rhythms in Child and Adolescent Mental Health
COBRE 儿童和青少年心理健康睡眠和昼夜节律中心
- 批准号:
10726745 - 财政年份:2021
- 资助金额:
$ 118.41万 - 项目类别:
Biomarkers of stress, allergy status, and structural changes of the airway and relations with sleep and asthma outcomes in urban children
城市儿童压力、过敏状态和气道结构变化的生物标志物以及与睡眠和哮喘结果的关系
- 批准号:
10392553 - 财政年份:2019
- 资助金额:
$ 118.41万 - 项目类别:
Disparities in Sleep, Asthma, and the Sleep Context in Urban Children
城市儿童睡眠、哮喘和睡眠环境的差异
- 批准号:
10813455 - 财政年份:2019
- 资助金额:
$ 118.41万 - 项目类别:
相似海外基金
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 118.41万 - 项目类别:
Standard Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 118.41万 - 项目类别:
Standard Grant
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 118.41万 - 项目类别:
Training Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 118.41万 - 项目类别:
Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 118.41万 - 项目类别:
Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 118.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 118.41万 - 项目类别:
Studentship
ERI: Developing a Trust-supporting Design Framework with Affect for Human-AI Collaboration
ERI:开发一个支持信任的设计框架,影响人类与人工智能的协作
- 批准号:
2301846 - 财政年份:2023
- 资助金额:
$ 118.41万 - 项目类别:
Standard Grant
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 118.41万 - 项目类别:
Operating Grants
How motor impairments due to neurodegenerative diseases affect masticatory movements
神经退行性疾病引起的运动障碍如何影响咀嚼运动
- 批准号:
23K16076 - 财政年份:2023
- 资助金额:
$ 118.41万 - 项目类别:
Grant-in-Aid for Early-Career Scientists