Mentored career development in clinical research in non-malignant hematology

描述(由申请人提供)： 这份申请描述了宾夕法尼亚大学和费城儿童医院计划培训非恶性血液学临床和转化研究的下一代领导者。血液学课程的广度和深度，以及大学的额外资源，为这一职业发展计划提供了理想的环境，该计划将被构建为涵盖四个领域，包括：止血、红细胞疾病、免疫血液学和输血医学以及干细胞和骨髓增殖性疾病。有经验的教师将领导每个领域，并协助主任和联席主任开发良性血液学的全面课程。这些教师将担任初级导师，并与次级导师一起，在各自的专业领域培训学者。此外，该计划将利用最近开发的转化医学和治疗研究所内的资源。该计划的具体培训目标是：1)提供基础广泛的临床培训，接触儿童和成人非恶性血液学的所有方面；2)指导学者获得成为一名成功的临床或翻译研究人员所需的知识和工具，包括生物统计学、流行病学、临床试验设计和负责任的研究指导；3)培养对与其临床研究重点领域相关的基础分子和细胞生物学进展以及在这些领域使用的方法有透彻了解的学者；4)确保对基础和临床生物医学研究中的伦理问题的知识和理解；以及，5)在明确的时间表内为学者提供密切的指导，以实现教育、研究以及科学和拨款撰写方面的目标，并在支持性的学术环境中提供积极的临床研究榜样。该计划将培训未来的良性血液学临床和翻译研究人员，他们拥有基础科学和临床研究方法论方面的复杂背景。预计该专业的毕业生将处于其研究领域的领先地位，并处于竞争进一步的NIH资金的理想位置，并在学术中心担任非恶性血液学的教员，培训下一代非恶性血液学家。

DESCRIPTION (provided by applicant): This application describes plans at the University of Pennsylvania and Children's Hospital of Philadelphia to train the next generation of leaders in clinical and translational research in non-malignant hematology. The breadth and depth of the hematology programs, along with additional resources at the University, provide an ideal setting for this career development program, which will be structured to cover four areas including: Hemostasis, Red Cell Disorders, Immune Hematology and Transfusion Medicine, and Stem Cells and Myeloproliferative Disorders. Experienced faculty members will lead each area and aid the Director and Co- Directors in developing a comprehensive curriculum in benign hematology. These faculty will serve as Primary Mentors, and with Secondary Mentors, will train scholars in their areas of expertise. In addtion, the program will utilize the resources within the recently developed Institute for Translational Medicine and Therapeutics. The specific training goals of this program are: 1) To provide broad-based clinical training and exposure to all aspects of pediatric and adult non-malignant hematology; 2) To guide the Scholar in acquiring the knowledge and tools necessary to be a successful clinical or translational researcher, including training in biostatistics, epidemiology, clinical trials design, and in the responsible conduct of research; 3) To develop scholars with a thorough understanding of advances in basic molecular and cell biology relevant to their areas of clinical research focus, and in methodologies used in these areas; 4) To ensure knowledge and understanding of ethical issues in both basic and clinical biomedical research; and, 5) To provide close mentoring of the scholars with defined timelines to meet goals in education, research, and scientific and grant writing, and to provide positive clinical research role models in a supportive academic environment. The program will train future clinical and translational researchers in benign hematology who are equipped with a sophisticated background in basic science and clinical research methodologies. It is anticipated that graduates of this program will be at the leading edge of their research field and ideally situated to compete for further NIH funding and to serve as faculty members in non-malignant hematology in academic centers, training the next generation of non-malignant hematologists.