Hypothalamic oxexin-synthesizing neurons regulate the ultradian Basic Rest-Activity Cycle (BRAC); studies in transgenic rats and mice

下丘脑oxexin合成神经元调节超电基本休息活动周期（BRAC）；

• 批准号: nhmrc : 1051826
• 负责人: Dr Youichirou Ootsuka
• 金额: $ 39.24万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/hypothalamic-oxexin-synthesizing-rats-mice/112240
• 关键词: Hypothalamic; oxexin; synthesizing; neurons; regulate

In the hypothalamus region of the brain there is a group of neurons that synthesize a neuropeptide messenger called orexin. In humans, malfunction of orexin neurons results in narcolepsy (abnormal sleepiness) and in disordered metabolism resulting in obesity. Our experiments, conducted in genetically-modified rats and mice, will elucidate the manner in which the orexin neurons integrate our behaviour (eg eating) with our physiological state (eg body and brain temperature, arterial blood pressure).

在大脑的下丘脑区域，有一组神经元合成一种称为食欲素的神经肽信使。在人类中，食欲素神经元的功能障碍导致发作性睡病（异常嗜睡）和导致肥胖的代谢紊乱。我们在转基因大鼠和小鼠中进行的实验将阐明食欲素神经元将我们的行为（例如进食）与我们的生理状态（例如身体和大脑温度，动脉血压）整合的方式。