Hypothalamic orexin neurons and the medullary sympathoadrenal centre: a key role in glucose homeostasis

低血糖或低血糖是糖尿病治疗的主要副作用。暴露在低血糖环境中会导致大脑(神经可塑性)的变化，从而降低人们对低血糖的认识，通常会产生严重的后果。低血糖会触发包括肾上腺素在内的几种激素的产生，肾上腺素可以恢复正常血糖。这一过程还没有完全被理解。这项研究项目将确定控制血糖的神经回路的关键组件。

Hypoglycaemia or low blood sugar is a major side-effect of the treatment of diabetes. Exposure to hypoglycaemia results in changes in the brain (neuroplasticity) that reduce the awareness of hypoglycaemia, often with serious consequences. Hypoglycaemia triggers the production of several hormones including adrenaline which restore normal blood glucose. This process is incompletely understood. This research project will identify key components of the neurocircuitry that controls blood sugar.