International Research

国际研究

• 批准号: 7697012
• 负责人: JEFFREY Samuel Allen STRINGER
• 金额: $ 7.29万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-16 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7697012
• 关键词: AIDS prevention; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adult; Adverse event; Africa; Africa South of the Sahara; African; American; Appointment; Area; Authorization documentation; Award; Behavioral; Biostatistics Core; Cells; Certification; Clinical; Clinical Trials; Collaborations; Commit; Communication; Country; Data Analyses; Databases; Developed Countries; Developing Countries; Development; Disease; Documentation; Electronic Mail; Ensure; Ethical Review; Ethics; Evaluation; Faculty; Fellowship Program; Fostering; Foundations; Freezing; Funding; Grant; Growth; HIV; HIV Infections; Health; Heterosexuals; Housing; International; Internet; Internships; Laboratories; Liquid substance; Manuscripts; Modeling; Monitor; Nitrogen; Pathogenesis; Perinatal; Phase; Photocopying; Plasma; Preparation; Prevalence; Prevention; Prevention program; Procedures; Process; Protocols documentation; Public Health; Range; Reporting; Research; Research Ethics Committees; Research Infrastructure; Research Methodology; Research Personnel; Research Project Grants; Research Training; Resources; Rwanda; Sampling; Scanning; Scientist; Security; Services; Shipping; Ships; Site; Specimen; Structure; Students; Teaching Hospitals; Telefacsimile; Telephone; Therapeutic Studies; Training; Training Programs; Training Support; Translational Research; Transportation; Travel; Tropical Disease; United States National Institutes of Health; Universities; Update; Visit; Word Processing; Work; Writing; Zambia; antiretroviral therapy; authority; base; data management; disease transmission; editorial; experience; interest; next generation; programs; protocol development; symposium; training project; transmission process; vaccine development; virus culture

More than 90% of the HIV infections in the world are in developing countries and 80% are in sub- Saharan Africa. HIV prevalence in African urban adults ranges from 10->30%. In the USA, there have been reductions in HIV transmission and disease following prevention campaigns and antiretroviral therapy. In contrast, until the last few years, HIV prevention programs in developing countries were not evidence-based and resources for monitoring and evaluation were lacking. There has been a substantial improvement in program planning since NIH funding was committed to train developing country researchers, to establish linkages with US-based scientists, and to implement locally relevant collaborative studies. When the UAB CFAR International core (IC) was first established in 1997, there was only one funded RO1 to conduct HIV research in Rwanda and Zambia. Since then, the IC has provided a hub for substantial growth and facilitated the establishment of HIVNET/HPTN, AIEDRN, and CIPRA projects; seven new RO1 funded studies from UAB and three from other US Universities; and four foundation funded projects. The IC has facilitated the integration of seven AITRP graduates as co-investigators in NIH funded grants and worked with four AITRP trainees to write their own NIH proposals (pending review July 02). The IC also established a one-year field internship for American MPH students. Twelve interns have graduated since 1998, all of whom are now project coordinators for NIH funded HIV projects in Zambia or Rwanda. The IC thus provided critical logistical support and trained staff for 17 newly funded research awards in the last 4 years. These projects span the behavioral, epidemiologic, clinical, pathogenesis, and vaccine development areas relevant to heterosexual and perinatal HIV transmission and treatment of HIV disease. In the next 5 years, the IC will provide support for structured communication between the various research groups. This will facilitate the identification of critical gaps and new opportunities, and ensure that the next generation of projects builds logically on the previous one. In the coming 5 years, we will maintain the model that has proved highly successful. The IC will provide practical assistance with development and implementation of collaborative projects (organization of formal and informal conferences and meetings between UAB and field-based researchers; facilitation of IRB clearance and approvals from relevant authorities); procurement, processing, storing, and shipping of samples; and Ioqistics of communication and travel (email, telephone, fax, word processing and scanning services; visas and airplane tickets; housing in Rwanda and Zambia). Through coordination of scientific exchanges, practical training, and leveraged collaborations, we will foster more translational research and continue to expand the cadre of experienced and committed youn 9 investi_lators from the US and Africa.

世界上90%以上的艾滋病毒感染者在发展中国家，80%在亚 撒哈拉非洲。非洲城市成年人的艾滋病毒流行率为10-> 30%。在美国， 预防运动和抗逆转录病毒治疗后，艾滋病毒传播和疾病减少。在 相比之下，直到最近几年，发展中国家的艾滋病预防计划才以证据为基础 缺乏监测和评价资源。有了很大的改善， 自NIH资助以来，项目规划致力于培训发展中国家的研究人员，以建立 与美国科学家建立联系，并开展与当地相关的合作研究。 当UAB CFAR国际核心（IC）于1997年首次成立时， 第一区域办事处在卢旺达和赞比亚进行艾滋病毒研究。从那时起，IC提供了一个枢纽， 增长，并促进了艾滋病毒/艾滋病网络/艾滋病毒/艾滋病传播网络、艾滋病教育和康复网络和艾滋病防治和康复中心项目的建立; 由UAB资助的研究和其他美国大学的三个;和四个基金会资助的项目。的IC 促进了七名AITRP毕业生作为NIH资助赠款的共同研究者的整合， 与四名AITRP学员一起编写他们自己的NIH提案（等待2002年7月的审查）。该1c还 为美国公共卫生硕士学生建立了为期一年的实地实习。自那时以来，已有12名实习生毕业 1998年，他们现在都是国家卫生研究院资助的赞比亚或卢旺达艾滋病毒项目的项目协调员。 因此，国际中心为17个新资助的研究项目提供了重要的后勤支持和培训人员 在过去的四年里。这些项目涵盖行为学、流行病学、临床、发病机理和疫苗 在与异性性行为和围产期艾滋病毒传播和艾滋病毒疾病治疗有关的发展领域，在 未来5年，IC将为各种研究之间的结构化沟通提供支持 组这将有助于确定关键差距和新的机会，并确保下一个 项目的生成在逻辑上建立在前一个项目的基础上。 在未来5年，我们将保持这一模式，这一模式已被证明是非常成功的。IC将提供 为制定和执行合作项目提供实际援助（组织正式的 UAB和实地研究人员之间的非正式会议;促进IRB 相关部门的许可和批准）;采购、加工、储存和运输 样品;以及通信和旅行的物流（电子邮件、电话、传真、文字处理和扫描 服务;签证和机票;在卢旺达和赞比亚的住房）。通过协调科学 交流，实践培训和杠杆合作，我们将促进更多的转化研究， 继续扩大来自美国和非洲的有经验和有责任心的年轻投资者队伍。