International Research

世界上90%以上的艾滋病毒感染者在发展中国家，80%在亚 撒哈拉非洲。非洲城市成年人的艾滋病毒流行率从10%到30%不等。在美国，已经有了 在开展预防运动和抗逆转录病毒治疗后，减少艾滋病毒传播和疾病。在……里面 相比之下，直到最近几年，发展中国家的艾滋病毒预防方案还没有证据 缺乏用于监测和评估的资源。这方面有了很大的改善 计划计划，因为NIH的资金致力于培训发展中国家的研究人员，以建立 与美国科学家建立联系，并开展与当地相关的合作研究。 当UAB CFAR国际核心(IC)于1997年首次成立时，只有一笔资金 RO1将在卢旺达和赞比亚进行艾滋病毒研究。从那时起，集成电路为大量的 增长并促进了HIVNET/HPTN、AIEDRN和CIPRA项目的建立；7个新的RO1 UAB资助的研究和其他美国大学资助的三项研究；以及四个基金会资助的项目。集成电路 促进了七名AITRP毕业生作为NIH资助的赠款和 与四名AITRP实习生一起撰写他们自己的NIH提案(等待审查，7月2日)。该IC还 为美国公共卫生硕士学生建立了为期一年的实地实习。自那以来已有12名实习生毕业 1998年，他们现在都是国立卫生研究院资助的赞比亚或卢旺达艾滋病毒项目的项目协调员。 因此，IC为17个新资助的研究奖项提供了关键的后勤支持和培训工作人员 在过去的四年里。这些项目涵盖行为、流行病学、临床、发病机制和疫苗。 与异性和围产期艾滋病毒传播和艾滋病毒疾病治疗有关的发展领域。在……里面 未来5年，IC将为各种研究之间的结构化沟通提供支持 组。这将有助于确定关键差距和新机会，并确保下一个 项目的生成在逻辑上建立在前一个项目的基础上。 在接下来的5年里，我们将保持已经被证明非常成功的模式。IC将提供 为合作项目的开发和实施提供实际援助(组织正式的 和非正式会议和联合调查小组与实地研究人员之间的会议；为内部审查委员会提供便利 有关当局的审批)；采购、加工、储存和运输 样本；通信和旅行的信息学(电子邮件、电话、传真、文字处理和扫描 服务；签证和机票；卢旺达和赞比亚的住房)。通过科学的协调 交流、实践培训和杠杆合作，我们将促进更多的翻译研究和 继续扩大来自美国和非洲的经验丰富、忠于职守的年轻投资者队伍。

More than 90% of the HIV infections in the world are in developing countries and 80% are in sub- Saharan Africa. HIV prevalence in African urban adults ranges from 10->30%. In the USA, there have been reductions in HIV transmission and disease following prevention campaigns and antiretroviral therapy. In contrast, until the last few years, HIV prevention programs in developing countries were not evidence-based and resources for monitoring and evaluation were lacking. There has been a substantial improvement in program planning since NIH funding was committed to train developing country researchers, to establish linkages with US-based scientists, and to implement locally relevant collaborative studies. When the UAB CFAR International core (IC) was first established in 1997, there was only one funded RO1 to conduct HIV research in Rwanda and Zambia. Since then, the IC has provided a hub for substantial growth and facilitated the establishment of HIVNET/HPTN, AIEDRN, and CIPRA projects; seven new RO1 funded studies from UAB and three from other US Universities; and four foundation funded projects. The IC has facilitated the integration of seven AITRP graduates as co-investigators in NIH funded grants and worked with four AITRP trainees to write their own NIH proposals (pending review July 02). The IC also established a one-year field internship for American MPH students. Twelve interns have graduated since 1998, all of whom are now project coordinators for NIH funded HIV projects in Zambia or Rwanda. The IC thus provided critical logistical support and trained staff for 17 newly funded research awards in the last 4 years. These projects span the behavioral, epidemiologic, clinical, pathogenesis, and vaccine development areas relevant to heterosexual and perinatal HIV transmission and treatment of HIV disease. In the next 5 years, the IC will provide support for structured communication between the various research groups. This will facilitate the identification of critical gaps and new opportunities, and ensure that the next generation of projects builds logically on the previous one. In the coming 5 years, we will maintain the model that has proved highly successful. The IC will provide practical assistance with development and implementation of collaborative projects (organization of formal and informal conferences and meetings between UAB and field-based researchers; facilitation of IRB clearance and approvals from relevant authorities); procurement, processing, storing, and shipping of samples; and Ioqistics of communication and travel (email, telephone, fax, word processing and scanning services; visas and airplane tickets; housing in Rwanda and Zambia). Through coordination of scientific exchanges, practical training, and leveraged collaborations, we will foster more translational research and continue to expand the cadre of experienced and committed youn 9 investi_lators from the US and Africa.