Clinical

临床核心是基础科学、临床、行为和流行病学之间的接口 研究人员和艾滋病患者。通过建立多个诊所， 综合临床数据库，临床标本库，社区和国际 外展项目和几个专门针对常见艾滋病毒相关并发症的特别项目 和合并感染，临床核心作为所有患者相关活动的中心， 进行临床试验，提供临床样本和临床结果信息， 100多名UAB CFAR调查人员和世界各地的调查人员。的具体目标 临床核心是：1）为急性胰腺炎相关的临床和转化研究提供基础设施 和早期艾滋病毒感染;儿童，青少年和成年人与确定的艾滋病毒/艾滋病;和艾滋病毒相关 疫苗。2)扩大学生和卫生保健工作者在各个阶段的教育机会， 培训和实践，以发展与临床试验设计、伦理行为和分析相关的技能。 research. 3)维护和更新1917诊所数据库-用于执行临床， 药物经济学和社会心理学结果研究，并确定潜在的研究对象-和 参与CFAR-综合临床系统网络（C-NICS）。4)收集、加工、储存和 将来自特征明确的患者的高质量血液和组织标本通过 综合临床标本库。5)提供药理学分析， 创新的、最先进的方法。6)促进跨学科项目，以更好地了解 艾滋病毒/抗逆转录病毒治疗的代谢并发症的发病机制和管理，以及 几种重要的HIV共病原体（尤其是STD、B型和C型肝炎）。7)提供外展 针对艾滋病毒高危特殊群体的教育、预防和治疗机会的项目 及其并发症。该应用程序描述了最近UAB CFAR程序开发， 反映了艾滋病流行的多样性和不断变化的面貌-越来越多的强调计算机化 患者记录、研究数据库和结果研究;增加国际研究合作 与急性和慢性艾滋病毒感染有关的努力;以及新的跨学科项目，重点是 重要的感染性共病原体和最近认识到的治疗相关并发症。保持 只有通过提供UAB，才有可能实现这种广泛的相互关联和协同的项目 CFAR基础设施、组织和资源。

The Clinical Core serves as an interface between basic science, clinical, behavioral, and epidemiologic investigators and patients with HIV disease. Through the establishment of multiple clinics, a Comprehensive Clinical Database, a Clinical Specimen Repository, community and international outreach projects, and several special programs focused on common HIV-related complications and co-infections, the Clinical Core serves as a hub for all patient-related activities, ranging from the conduct of clinical trials to provision of clinical specimens and clinical outcome information to the 100+ UAB CFAR investigators and investigators around the world. The SPECIFIC AIMS of the Clinical Core are to: 1) Provide infrastructure for clinical and translational research related to acute and early HIV infection; children, adolescents, and adults with established HIV/AIDS; and HIV-related vaccines. 2) Expand educational opportunities for students and health care workers at all phases of training and practice to develop skills related to the design, ethical conduct, and analysis of clinical research. 3) Maintain and update the 1917 Clinic Database -- used to perform clinical, pharmacoeconomic, and psychosocial outcome studies and to identify potential research subjects -- and participate in the CFAR-Network of Integrated Clinical Systems (C-NICS). 4) Collect, process, store, and distribute high-quality blood and tissue specimens from well-characterized patients to investigators via a Comprehensive Clinical Specimen Repository. 5) Provide pharmacologic analyses utilizing innovative, state-of-the-art methodologies. 6) Foster interdisciplinary programs to better understand the pathogenesis and management of metabolic complications of HIV/antiretroviral therapies as well as several important HIV co-pathogens (especially STDs, Hepatitis B and C). 7) Provide outreach programs targeting education, prevention, and treatment opportunities for special groups at risk for HIV and its complications. This application describes recent UAB CFAR programmatic developments that reflect the diverse and changing face of the AIDS epidemic - an increasing emphasis on computerized patient records, research database, and outcomes research; increasing international research collaborative efforts related to acute and chronic HIV infection; and new interdisciplinary programs focused on critically important infectious co-pathogens and recently recognized treatment-related complications. Maintaining this broad array of inter-connected and synergistic projects is possible only through the provision of UAB CFAR infrastructure, organization, and resources.