Clinical

临床核心已经运行了20年，提供促进翻译接口的服务 基础科学、临床、行为和流行病学研究人员与艾滋病毒感染患者之间的关系。具体的 临床核心的目标是： 1.提供一个全面的标本储存库，提供高效的收集、处理、存储、 临床标本的质量保证跟踪、分发和运输 涉及多个研究学科的协作性研究。 2.提供创新的计算机化数据库和信息学服务？资源和 存储和访问复杂的交互数据的设备以及协助研究设计的专业知识， 确定符合研究方案进入标准的受试者，进行适当的数据分析和 对结果提供详细和相关的解释。 3.建立新的方法和技术，使CFAR更容易获得临床样本 成员们意识到，尽管我们在促进创新的翻译方面取得了许多成功 研究，我们必须努力改进这一进程。 4.提供研究培训服务，以支持各级(从学生到研究人员再到经验丰富的人员 教师更新他们的技能)国内和国际的临床研究。 虽然这些服务中的每一项自我们的CFAR开始以来一直在运营，但每项服务都在继续增长和 根据调查人员的需求进行实质性的多样化。需要临床核心服务的出版物继续 在上一次供资期间，每年都会增加。样本与信息紧密相连， 计算机化的数据库，这种协同作用在与艾滋病毒有关的新发现中发挥了重要作用 发病机制，了解免疫反应和疫苗开发。最近，病历系统和 研究数据库已完全电子化，使用完全由CFAR设计和管理的软件 具有信息学、统计学和计算机技术专业知识的调查人员。这些进步使CFAR 处于领导协作临床数据库和基于结果的国内和国际研究人员的独特地位 项目，并对有关卫生保健机会和成本效益的政策辩论作出有意义的贡献。一个 加强了各种国内科研培训服务，同时加强了国际科研培训工作 最好的例证是与国际核心组织充分合作，提供临床核心支持。这些临床核心服务 对于在DAB和世界各地进行大量的艾滋病毒/艾滋病研究是必不可少的。

The Clinical Core has been in operation for twenty years to provide services that foster the translational interface between basic science, clinical, behavioral, and epidemiologic investigators and HIV-infected patients. The Specific Aims of the Clinical Core are: 1. To provide a Comprehensive Specimen Repository offering the efficient collection, processing, storage, quality assurance tracking, distribution, and shipping of clinical specimens obtained from wellcharacterized patients for collaborative investigations involving multiple research disciplines. 2. To provide an innovative Computerized Database and Informatics Service¿the resources and equipment to store and access complex, interactive data and the expertise to assist with study design, identify subjects who meet entry criteria for research protocols, conduct appropriate data analyses and provide detailed and relevant interpretation of results. 3. To establish new methods and technologies to make clinical samples more readily accessible to CFAR members realizing that despite the numerous successes we have had in fostering innovative translational research, we must strive to improve this process. 4. To provide Research Training Services to support all levels (from students to research staff to seasoned faculty updating their skills) of domestic and international clinical research. While each of these services has been in operation since the beginning of our CFAR, each continues to grow and diversify substantially in response to investigator needs. Publications requiring Clinical Core services have continued to increase every year during the last funding period. Specimens are integrally linked with information in the Computerized Database, and this synergy has played an important role in new discoveries related to HIV pathogenesis, understanding immune responses and vaccine development. Recently, the medical record system and research database have become fully electronic, utilizing software completely designed and managed by CFAR investigators with expertise in informatics, statistics and computer technology. These advancements place CFAR investigators in a unique position to lead collaborative clinical database and outcomes-based national and international projects, and to contribute meaningfully to policy debates regarding health care access and cost-effectiveness. A variety of domestic research training services have been strengthened, while international research training efforts are best exemplified by Clinical Core support, in full collaboration with the International Core. These Clinical Core services are essential for the conduct of a vast array of HIV/AIDS research at DAB and around the world.