Clinical

临床

• 批准号: 7685017
• 负责人: Paul A. Goepfert
• 金额: $ 38.66万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-15 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7685017
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adherence; Advertisements; Anti-Retroviral Agents; Appointment; Area; Arts; Basic Science; Behavioral; Behavioral Sciences; Biometry; Characteristics; Clinic; Clinical; Clinical Research; Collaborations; Collection; Complex; Computer software; Computers; DNA Sequence; Data; Data Analyses; Databases; Development; Discipline; Electronics; Ensure; Equipment; Faculty; Fostering; Funding; HIV; Health Personnel; Health Services Accessibility; Health behavior; Healthcare; Human Resources; Immune response; Individual; Informatics; Institution; International; Investigation; Lead; Leadership; Link; Mails; Medical Records; Mental disorders; Mentors; Methods; Newsletter; Observational Study; Operative Surgical Procedures; Outcome; Pathogenesis; Patients; Pharmaceutical Preparations; Plasmapheresis; Play; Policies; Positioning Attribute; Process; Productivity; Protocols documentation; Publications; Publishing; Research; Research Design; Research Methodology; Research Personnel; Research Subjects; Research Training; Resources; Role; Sampling; Seasons; Services; Shipping; Ships; Site; Specimen; Stream; Students; Substance abuse problem; System; Techniques; Technology; Training; Translational Research; Update; Work; Zambia; base; career; cohort; computerized; cost effectiveness; design; improved; innovation; interest; meetings; member; prospective; quality assurance; repository; research study; response; skills; statistics; success; systems research; vaccine development; virology; web site

The Clinical Core has been in operation for twenty years to provide services that foster the translational interface between basic science, clinical, behavioral, and epidemiologic investigators and HIV-infected patients. The Specific Aims of the Clinical Core are: 1. To provide a Comprehensive Specimen Repository offering the efficient collection, processing, storage, quality assurance tracking, distribution, and shipping of clinical specimens obtained from wellcharacterized patients for collaborative investigations involving multiple research disciplines. 2. To provide an innovative Computerized Database and Informatics Service¿the resources and equipment to store and access complex, interactive data and the expertise to assist with study design, identify subjects who meet entry criteria for research protocols, conduct appropriate data analyses and provide detailed and relevant interpretation of results. 3. To establish new methods and technologies to make clinical samples more readily accessible to CFAR members realizing that despite the numerous successes we have had in fostering innovative translational research, we must strive to improve this process. 4. To provide Research Training Services to support all levels (from students to research staff to seasoned faculty updating their skills) of domestic and international clinical research. While each of these services has been in operation since the beginning of our CFAR, each continues to grow and diversify substantially in response to investigator needs. Publications requiring Clinical Core services have continued to increase every year during the last funding period. Specimens are integrally linked with information in the Computerized Database, and this synergy has played an important role in new discoveries related to HIV pathogenesis, understanding immune responses and vaccine development. Recently, the medical record system and research database have become fully electronic, utilizing software completely designed and managed by CFAR investigators with expertise in informatics, statistics and computer technology. These advancements place CFAR investigators in a unique position to lead collaborative clinical database and outcomes-based national and international projects, and to contribute meaningfully to policy debates regarding health care access and cost-effectiveness. A variety of domestic research training services have been strengthened, while international research training efforts are best exemplified by Clinical Core support, in full collaboration with the International Core. These Clinical Core services are essential for the conduct of a vast array of HIV/AIDS research at DAB and around the world.

临床核心已经运作了二十年，提供促进翻译界面的服务 基础科学、临床、行为和流行病学调查人员与HIV感染者之间的关系。具体 临床核心的目的是： 1.提供一个全面的标本库，提供有效的收集，处理，储存， 质量保证跟踪、分发和运输从表征良好的 患者进行涉及多个研究学科的合作研究。 2.提供创新的计算机化数据库和信息服务， 用于存储和访问复杂的交互式数据的设备以及用于协助研究设计的专业知识， 确定符合研究方案入选标准的受试者，进行适当的数据分析， 提供详细和相关的结果解释。 3.建立新的方法和技术，使临床样本更容易获得CFAR 成员们认识到，尽管我们在促进创新翻译方面取得了许多成功， 研究，我们必须努力改善这一进程。 4.提供研究培训服务，以支持各级（从学生到研究人员，以经验丰富的 教师更新他们的技能）的国内和国际临床研究。 虽然这些服务中的每一个都是从我们的CFAR开始运行的，但每一个都在继续增长， 根据调查人员的需求进行大幅多样化。需要临床核心服务的出版物继续 在上一个供资期间，每年都在增加。样本与中的信息紧密相连 计算机化数据库，这种协同作用在与艾滋病毒相关的新发现中发挥了重要作用 发病机制，了解免疫反应和疫苗开发。最近，医疗记录系统和 研究数据库已完全电子化，使用完全由CFAR设计和管理的软件 具有信息学、统计学和计算机技术专门知识的调查员。这些进步将CFAR 研究者处于独特的地位，能够领导基于国家和国际的协作临床数据库和结局 项目，并有意义地促进有关卫生保健的获取和成本效益的政策辩论。一 各种国内研究培训服务得到加强，而国际研究培训工作也得到加强。 最好的例证是临床核心支持，与国际核心充分合作。这些临床核心服务 对于在DAB和世界各地进行大量的HIV/AIDS研究至关重要。