Virology/Immunology Core

病毒学/免疫学核心的总体使命是加强艾滋病毒相关研究， 促进艾滋病毒调查人员之间的合作，通过提供更好的获得病毒学和 免疫测定、临床标本和重组DNA构建体。 该核心的具体目标是： 1.提供一个中央储存库，存放临床样本及与艾滋病病毒有关的重组DNA 可以被临床、行为和实验室研究者使用的结构。 2.为了集中和改善对最先进的病毒学检测的使用，用于临床，行为， 实验室调查员。 3.提供一个生产与艾滋病毒研究有关的重组蛋白的集中设施。 4.提供流式细胞术分析设计和解释方面的专业知识，并提高 访问进行这些研究所需的共享仪器。 5.改善现有URMC核心设施的使用。 该核心将利用和增强现有的基础设施，例如冷存储中的基础设施 设施（目标1）、传染病科实验室（目标2）、人类免疫学中心（目标4），以及 现有的核心设施（目标5）。此外，我们将集中表达某些 重组蛋白（目标3），以便为在HIV相关研究中使用它们的研究人员提供规模经济 research.病毒学/免疫学核心将执行UR D-CFAR的总体使命 通过支持来自乌拉圭回合及其在南方的国际合作者的广泛调查人员， 非洲，并促进它们之间的跨学科合作。

The overall mission of the Virology/Immunology Core is to enhance HIV-related research and promote collaborations among HIV investigators, by providing improved access to virologic and immunologic assays, clinical specimens, and recombinant DMA constructs. The specific aims of this Core are: 1. To provide a centralized repository for clinical specimens and HIV-related recombinant DMA constructs that can be used by clinical, behavioral, and laboratory investigators. 2. To centralize, and improve access to, state-of-the-art virologic assays for clinical, behavioral, and laboratory investigators. 3. To provide a centralized facility that produces recombinant proteins relevant to HIV research. 4. To provide expertise in the design and interpretation of flow cytometry assays, and to improve access to the shared instrumentation necessary to conduct these studies. 5. To provide improved access to existing URMC core facilities. This core will utilize and augment already existing infrastructures, such as those in the Cold Storage Facility (Aim 1), Infectious Diseases Unit laboratories (Aim 2), Human Immunology Center (Aim 4), and existing core facilities (Aim 5) at the URMC. In addition, we will centralize expression of certain recombinant proteins (Aim 3), in order to provide economy of scale to investigators that use them in HIVrelated research. The Virology/Immunology Core will implement the overall mission of the UR D-CFAR by supporting a broad base of investigators from the UR and its international collaborators in South Africa, and promoting interdisciplinary collaborations among them.