Clinical Science Core

临床科学核心

• 批准号: 7479041
• 负责人: MICHAEL C KEEFER
• 金额: $ 16.96万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7479041
• 关键词: AIDS/HIV problem; Address; African; Area; Biological Assay; Biometry; Clinical; Clinical Pharmacology; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Conduct Clinical Trials; Face; Foundations; Goals; Gray unit of radiation dose; HIV; Immunology; Institution; International; Laboratories; Modeling; Operative Surgical Procedures; Perinatal; Population Study; Process; Protocols documentation; Research; Research Activity; Research Personnel; Services; South Africa; Strategic Planning; Structure; Translational Research; Universities; Work; base; design; experience; programs; restraint; translational study; virology

CLINICAL SCIENCES CORE (CORE C) The Clinical Sciences Core (CSC; Core C) will be the focal point of all D-CFAR clinical and translational research activities. A major goal for the Core will be to provide expertise and services to facilitate the design, implementation and conduct of HIV/AIDS clinical trials by D-CFAR investigators. The Core will be directed by Dr. Michael Keefer, who has extensive administrative and clinical research experience. The Core will provide support for clinical and translational research by developing a "Protocol Team Service" that draws on the 20 year experience of the major UR HIV/AIDS clinical research programs. While fiscal restraints obviously limit the extent to which a "network-like" support structure can be established, our extensive expertise will allow us to proceed in a step-wise fashion to provide an 'investigator-centered' service that addresses the most pressing needs that clinical researchers face as they design, implement and conduct their studies. The "Protocol Team Service" will also leverage other expertise within the D-CFAR and the UR institution as a whole to present a coordinated menu of services that the program's D-CFAR investigators can access. Intellectual assistance will be provided through a "protocol design" service, and laboratory assays provided in collaboration with the Virology/Immunology Core (Core D). A second area of focus for Core C will be the creation of a "Biostatistical Service" designed to meet investigator needs that were identified during the strategic planning process for this D-CFAR application (including the needs of international partners in South Africa; see below). The third area of emphasis will be on "Specialized Services" - notably biomathematical modeling (which is a major institutional strength at UR) and clinical pharmacology services. Finally, the activities and services of Core C will be designed to build upon the growing collaboration that the UR is nurturing with successful research colleagues in South Africa. Dr. Keefer's current close working relationship with Dr. Glenda Gray (U-Witwatersrand [UWj / Perinatal HIV Research Centre [PHRU]) and Dr. Linda-Gail Bekker (U-Cape Town [UCT] / Desmond Tutu HIV Centre [DTHC]) through HVTN operations will form the initial foundation of the collaboration. It is our goal for the UR-South African collaboration to evolve into a broad-based inter-institutional collaboration in years to come.

临床科学核心(核心C) 临床科学核心(CSC；核心C)将是所有D-CFAR临床和 翻译研究活动。核心的一个主要目标将是提供专门知识和服务 促进D-CFAR调查员设计、实施和进行艾滋病毒/艾滋病临床试验。 Core将由Michael Keefer博士领导，他拥有广泛的管理和临床研究 经验。该核心将通过开发一种 “礼宾团队服务”--借鉴UR主要艾滋病毒/艾滋病诊所20年的经验 研究项目。虽然财政限制显然限制了“网络式”支持的程度 结构可以建立，我们丰富的专业知识将使我们能够循序渐进地 提供以研究人员为中心的服务，满足临床上最迫切的需求 研究人员在设计、实施和进行他们的研究时面临着挑战。“协议团队服务” 还将利用D-CFAR和UR机构内部的其他专业知识，作为一个整体提交 该项目的D-CFAR调查人员可以访问的协调服务菜单。知识分子 将通过“方案设计”服务提供协助，并在 与病毒学/免疫学核心(核心D)合作。Core C的第二个重点领域将是 创建了一个“生物统计服务”，旨在满足期间确定的调查人员需求 这一D-CFAR应用的战略规划过程(包括国际合作伙伴的需求 在南非；见下文)。第三个重点领域将是“专门服务”--特别是 生物数学建模(UR的一个主要机构优势)和临床药理学 服务。最后，核心C的活动和服务将在不断增长的 UR正在培育与南非成功的研究同事的合作。基弗医生的 目前与格伦达·格雷博士的密切工作关系(U-Witwater srand[UWJ/围产期艾滋病毒 研究中心[Phru])和Linda-Gail Bekker博士(U-开普敦[UCT]/Desmond Tutu艾滋病毒中心 [DTHC])通过HVTN运营将构成合作的初始基础。这是我们的目标 多年来，乌鲁木齐-南非的合作演变为基础广泛的机构间合作 来吧。