Intravascular Photoacoustic Imaging of Atherosclerotic Plaques

动脉粥样硬化斑块的血管内光声成像

• 批准号: 7391647
• 负责人: STANISLAV Y EMELIANOV
• 金额: $ 20万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7391647
• 关键词: Ablation; Accounting; Acoustics; Address; Animals; Area; Arterial Fatty Streak; Atherosclerosis; Balloon Angioplasty; Biochemical; Biomedical Engineering; Brachytherapy; Cardiology; Cessation of life; Clinical; Clinical Engineering; Coronary artery; Coronary heart disease; Custom; Development; Diagnostic Imaging; Diagnostic Procedure; Disease; Elements; Evaluation; Event; Foundations; Frequencies; Goals; Image; Imaging Device; Imaging Techniques; Imaging technology; Intervention; Laboratories; Lasers; Microsurgery; Modality; Modeling; Monitor; Numbers; Optics; Oryctolagus cuniculus; Outcome; Patients; Performance; Property; Protocols documentation; Range; Research; Research Project Grants; Resolution; Risk; Rupture; Scanning; Screening procedure; Slide; Source; Structure; Symptoms; System; Technology; Testing; Tissue Sample; Tissues; Transducers; Ultrasonics; Ultrasonography; United States; United States National Institutes of Health; Work; animal tissue; base; cancer imaging; cardiovascular imaging; cellular imaging; design; improved; in vivo; insight; performance tests; programs; prototype; tool; vaporization

DESCRIPTION (provided by applicant): In the United States alone, approximately 500,000 deaths will result from rupture of plaques considered "insignificant" on an angiographic evaluation. Available screening and diagnostic methods are insufficient to identify the victims before the event occurs. Therefore, there is a definite and urgent clinical need for an imaging technique that can identify and characterize the vulnerability of atherosclerotic plaques during coronary artery interventions. The overall goal of our research program is to develop an in-vivo imaging technology - intravascular photoacoustic imaging - capable of visualizing both structural and functional properties of atherosclerotic plaques. The underlying hypothesis of this project is that intravascular photoacoustic (IVPA) imaging combined with intravascular ultrasound (IVUS) imaging is possible and can be used to distinguish vulnerable plaques, thus assisting pre-intervention planning, the intervention itself, and improving the post-intervention outcome. Most importantly, the proposed photoacoustic imaging will not significantly change the current protocol of coronary artery intervention. A wide range of technical, scientific and clinical problems must be addressed to fully explore the capabilities of intravascular photoacoustic imaging in interventional cardiology. The central theme of the current project is to address the areas of known technical concerns so that the broader developmental efforts may proceed with minimal risk. The main objective of this R21 application is, therefore, to develop and initially test a prototype of the photoacoustic imaging system for intravascular applications. To achieve our objective, we will first design and build the intravascular photoacoustic imaging system based on a mechanically scanned, single element transducer IVUS cathetrer interfaced with a tunable laser source. We will also develop both theoretical and numerical foundations for photoacoustic and ultrasound imaging to optimize the performance of the system. Second, we will test the developed imaging system using tissue mimicking phantoms. Third, the developed imaging system will be tested using animal tissue samples where ultrasonic and photoacoustic images will be correlated with histological slides and biochemical analysis of tissue. Finally, based on the insights gathered during the project, we will outline the design and technical specifications of an intravascular photoacoustic imaging system. Atherosclerotic cardiovascular disease results in more than 19 million deaths annually, and coronary heart disease accounts for the majority of this toll. Despite major advances in treatment of coronary heart disease patients, a large number of victims of the disease who are apparently healthy die suddenly without prior symptoms. Available screening and diagnostic methods are insufficient to identify the victims before the event occurs - in the United States alone, approximately 500,000 deaths per year will result from rupture of plaques considered "insignificant" on an angiographic evaluation. Therefore, there is a definite and urgent clinical need for an imaging technique that can identify and characterize the vulnerability of atherosclerotic plaques during coronary artery interventions including percutaneous balloon angioplasty, endovascular stenting, ablation/vaporization and brachytherapy.

描述(申请人提供)：仅在美国，就有大约500,000例死亡病例是由于血管造影评估认为“微不足道”的斑块破裂造成的。现有的筛查和诊断方法不足以在事件发生前确定受害者。因此，临床上迫切需要一种能够在冠状动脉介入治疗中识别和表征动脉粥样硬化斑块易损性的成像技术。我们研究计划的总体目标是开发一种体内成像技术-血管内光声成像-能够可视化动脉粥样硬化斑块的结构和功能属性。该项目的基本假设是，血管内光声(IVPA)成像与血管内超声(IVUS)成像相结合是可能的，并可用于区分易损斑块，从而辅助介入前计划、介入本身，并改善介入后的结果。最重要的是，拟议的光声成像不会显著改变目前的冠状动脉介入治疗方案。为了充分探索血管内光声成像在介入心脏病学中的能力，必须解决广泛的技术、科学和临床问题。当前项目的中心主题是解决已知的技术关切领域，以使更广泛的发展努力能够以最小的风险进行。因此，R21应用的主要目标是开发和初步测试用于血管内应用的光声成像系统的原型。为了实现我们的目标，我们将首先设计和建立基于机械扫描的单元件换能器IVUS阴极和可调激光光源的血管内光声成像系统。我们还将为光声和超声成像建立理论和数值基础，以优化系统的性能。其次，我们将使用组织模拟模型来测试开发的成像系统。第三，开发的成像系统将使用动物组织样本进行测试，其中超声波和光声图像将与组织的组织切片和生化分析相关联。最后，基于在项目期间收集到的见解，我们将概述血管内光声成像系统的设计和技术规格。动脉粥样硬化性心血管疾病每年导致1900多万人死亡，而冠心病占死亡人数的大部分。尽管在治疗冠心病患者方面取得了重大进展，但大量表面上健康的患者突然死亡，没有先前的症状。现有的筛查和诊断方法不足以在事件发生前识别受害者--仅在美国，每年就有大约500,000人死于血管造影评估认为“微不足道”的斑块破裂。因此，临床上迫切需要一种能够识别和表征冠状动脉介入治疗过程中动脉粥样硬化斑块易损性的成像技术，包括经皮球囊血管成形术、血管内支架置入术、消融/汽化和近距离放射治疗。

项目成果

Display pixel-based synthetic aperture focusing method for intravascular ultrasound imaging.

显示基于像素的血管内超声成像合成孔径聚焦方法。

• DOI: 10.1109/iembs.2009.5335164
• 发表时间: 2009
• 期刊: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
• 作者: Kim,Seungsoo;Aglyamov,SalavatR;Emelianov,StanislavY
• 通讯作者: Emelianov,StanislavY

In vivo intravascular ultrasound-guided photoacoustic imaging of lipid in plaques using an animal model of atherosclerosis.

• DOI: 10.1016/j.ultrasmedbio.2012.08.006
• 发表时间: 2012-12
• 期刊: ULTRASOUND IN MEDICINE AND BIOLOGY
• 影响因子: 2.9
• 作者: Wang, Bo;Karpiouk, Andrei;Yeager, Doug;Amirian, James;Litovsky, Silvio;Smalling, Richard;Emelianov, Stanislav
• 通讯作者: Emelianov, Stanislav

On the possibility to detect lipid in atherosclerotic plaques using intravascular photoacoustic imaging.

关于使用血管内光声成像检测动脉粥样硬化斑块中脂质的可能性。

• DOI: 10.1109/iembs.2009.5334213
• 发表时间: 2009
• 期刊: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
• 作者: Wang,Bo;Su,Jimmy;Amirian,James;Litovsky,SilvioH;Smalling,Richard;Emelianov,Stanislav
• 通讯作者: Emelianov,Stanislav

Intravascular Photoacoustic Imaging.

• DOI: 10.1109/jstqe.2009.2037023
• 发表时间: 2010-06-03
• 期刊: IEEE journal of quantum electronics
• 影响因子: 2.5
• 作者: Wang B;Su JL;Karpiouk AB;Sokolov KV;Smalling RW;Emelianov SY
• 通讯作者: Emelianov SY