Research Education in Statistical Genetics of Substance Abuse

药物滥用统计遗传学研究教育

• 批准号: 7590562
• 负责人: MICHAEL CHURTON NEALE
• 金额: $ 28.76万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7590562
• 关键词: Address; Alcohol or Other Drugs use; Area; Behavioral Genetics; Biometry; Clinical; Communities; Dependence; Development; Doctor of Philosophy; Drug abuse; Education; Education Projects; Educational Curriculum; Educational process of instructing; Educational workshop; Environment; Fostering; Future; Genetic; Goals; Human; Individual; Institutes; Institution; Interdisciplinary Study; Internet; Libraries; Mathematics; Mentors; Mission; Molecular Genetics; Monitor; National Institute of Drug Abuse; Participant; Pharmacology; Positioning Attribute; Psychology; Public Health; Publishing; Range; Recruitment Activity; Research; Research Personnel; Research Project Grants; Research Training; Statistical Methods; Substance abuse problem; Time; Training; Training Programs; Universities; Virginia; career; cohort; design; field study; genetic epidemiology; multidisciplinary; post-doctoral training; pre-doctoral; programs; software development; statistics

DESCRIPTION (provided by applicant): This application seeks support from the National Institute on Drug Abuse R25 mechanism for pre-doctoral and postdoctoral research positions at the Virginia Institute for Psychiatric and Behavioral Genetics (VIPBG) at Virginia Commonwealth University (VCU). The overall goal of this research education program is to provide an environment that encourages the development and application of statistical genetics at the highest levels. To accomplish this goal, a research education program in statistical genetics will been developed to foster interdisciplinary research, a key tenet of the NIDA mission, and which we believe is essential to conducting research in this field. Two areas of research focus are identified: Advanced Genetic Epidemiology and Statistical Molecular Genetics. These areas are synergistic and address a diverse variety of statistical methods, both those in current use and those under development. The research education program consists of pre-doctoral and postdoctoral components. Pre-doctoral participants will pursue degrees in either Human and Molecular Genetics or Biostatistics. This component is designed to recruit, at the earliest time in their careers, potential future investigators to research in statistical genetics focused on substance use, abuse and dependence (SUAD). The aim is to create a cohort of PhD graduates who are have been extensively exposed to, and begun to publish research in, this area at the outset of their research training. The postdoctoral component recognizes that many promising young researchers have training in areas relevant to, but not focused on, the statistical genetics of substance use and abuse. This flexible 2-3 year postdoctoral training component will help guide young investigators to this field of study and will provide them with integrated and focused training that will enable them to pursue careers in statistical genetics of SUAD. Research education is intended for individuals with training in mathematics, statistics, biostatistics, genetics, psychology or pharmacology and to those who have completed their clinical requirements for the MD degree. The goal of the postdoctoral component is to educate independent investigators who will contribute to the efforts to identify and characterize the genetic and environmental determinants of SUAD; they are expected to do so at VCU and at other institutions nationwide. To accomplish the overall program goal we will: i) Offer and carefully monitor a multidisciplinary integrated research training program with a range of research opportunities; ii) Meet the needs for training in emerging research areas in SUAD; iii) Provide training to researchers from diverse academic and ethnic backgrounds and intensive mentoring; iv) Provide a specialized curriculum that will merge strengths in SUAD research at our institution; and v) Disseminate course materials, developed software, user guides and example scripts to the wider community by teaching workshops and establishing a website with web casts, pod casts and script libraries. PUBLIC HEALTH RELEVANCE: This project seeks support from the NIDA R25 research education program in statistical genetics of substance abuse. Two pre-doctoral and three postdoctoral participants will pursue individualized courses of training in statistical genetics, and participate in active research projects in the Virginia Institute for Psychiatric and Behavioral Genetics at Virginia Commonwealth University.

描述（由申请人提供）：本申请寻求国家药物滥用研究所R25机制的支持，以获得弗吉尼亚联邦大学（VCU）弗吉尼亚精神病和行为遗传学研究所（VIPBG）的博士前和博士后研究职位。该研究教育计划的总体目标是提供一个环境，鼓励最高水平的统计遗传学的发展和应用。为了实现这一目标，统计遗传学的研究教育计划将被开发，以促进跨学科的研究，NIDA的使命的一个关键原则，我们认为这是必不可少的在这一领域进行研究。确定了两个研究重点领域：高级遗传流行病学和统计分子遗传学。这些领域具有协同作用，涉及各种统计方法，包括目前使用的和正在开发的统计方法。研究教育计划由博士前和博士后组成。博士前参与者将攻读人类和分子遗传学或生物统计学学位。这一部分的目的是招募，在他们的职业生涯的最早时间，潜在的未来的研究人员在统计遗传学研究集中在物质使用，滥用和依赖（SUAD）。其目的是创建一批博士毕业生，他们在研究培训开始时就广泛接触并开始发表这一领域的研究成果。博士后部分承认，许多有前途的年轻研究人员在与药物使用和滥用的统计遗传学有关的领域接受了培训，但并不侧重于这一领域。这个灵活的2-3年博士后培训部分将有助于指导年轻的研究人员到这一研究领域，并将为他们提供综合和集中的培训，使他们能够从事SUAD统计遗传学的职业。研究教育的目的是为个人在数学，统计学，生物统计学，遗传学，心理学或药理学的培训，以及那些谁已经完成了他们的临床要求的MD学位。博士后部分的目标是教育独立的调查人员，他们将有助于识别和描述SUAD的遗传和环境决定因素;他们预计将在VCU和全国其他机构这样做。为了实现整体计划目标，我们将：i）提供并仔细监控 多学科综合研究培训计划，提供一系列研究机会; ii）满足SUAD新兴研究领域的培训需求; iii）为研究人员提供培训， 我们的目标是：（a）提供多样化的学术和种族背景以及密集的指导;（b）提供专业课程，将我们机构在SUAD研究方面的优势融合在一起;以及（c）通过教学研讨会和建立一个有网络广播、播客和脚本库的网站，向更广泛的社区传播课程材料、开发的软件、用户指南和示例脚本。公共卫生相关性：该项目寻求NIDA R25研究教育计划在药物滥用统计遗传学方面的支持。两名博士前和三名博士后参与者将参加统计遗传学的个性化培训课程，并参加弗吉尼亚联邦大学弗吉尼亚精神病和行为遗传学研究所的积极研究项目。