CELL, MOLECULAR AND ANIMAL CORE

细胞、分子和动物核心

• 批准号: 7192128
• 负责人: GARY Andrew WEISMAN
• 金额: $ 30.8万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7192128
• 关键词: Advisory Committees; Alzheimer' s Disease; Animal Model; Animals; Budgets; Cell model; Cells; Chronic; Consultations; Disease Progression; Doctor of Philosophy; Educational Activities; Emergency Situation; Equipment; Fostering; Funding; Goals; Grant; Human Resources; Inflammation; International; Lipids; Missouri; Molecular; Neuronal Dysfunction; Oxidative Stress; Pathogenesis; Phenotype; Prevention strategy; Program Research Project Grants; Research; Research Personnel; Research Project Grants; Research Training; Resources; Series; Signal Pathway; Training Programs; Universities; Visit; cost; design; innovation; programs; repaired; success; symposium

The University of Missouri-Columbia (MU) Program Project Grant (PPG), Cell Models for AD: Lipids and Related Signaling Pathways, is a comprehensive research and training program that investigates the impact of oxidative stress and oligomeric Ap on neuronal dysfunction and chronic inflammation using appropriate cell and animal models that express different phenotypes of AD. The Administrative Core is a key component for the success of the PPG. The overall goal of the Administrative Core, led by Grace Y. Sun, PhD, is to provide cohesiveness to the PPG by overseeing and supervising Research Projects and Cores. This effort includes, but is not limited to, the administration of the budget and high cost resources, the coordination of visits by invited speakers, the organization of meetings for the internal and external advisory boards, and interactions with other NIA- funded investigators conducting research on Alzheimer's disease and NIA Program Officers. The PPG is comprised of three highly integrated projects and two cores. Specific aims for Core A are: 1) Coordinate and oversee the PPG administrative activities; 2) Foster interactions among PPG researchers; 3) Organize a seminar series to focus on AD and related subjects; 4) Provide statistical consultations; 5) Provide emergency funds for equipment repair or replacement of small equipment; 6) Design a website for the PPG; 7) Establish the Advisory Committee; and 8) Organize national and international symposia and meetings of the PPG Executive Committee. With the exception of partial support for personnel, major support for Administrative Core A is through a grant from the University of Missouri-Columbia PRIME Fund. MU will provide funds to establish new educational activities by supporting visits of seminar speakers to the MU campus, by organizing local, national and international symposia that will enhance research on the pathogenesis of AD, and by promoting innovative strategies for the prevention and retardation of disease progression.

密苏里-哥伦比亚大学（MU）计划项目资助（PPG），AD细胞模型：脂质和 相关信号通路，是一个全面的研究和培训计划，调查的影响， 氧化应激和寡聚Ap对神经元功能障碍和慢性炎症的影响， 表达不同AD表型的细胞和动物模型。行政核心是一把钥匙 这是PPG成功的关键。行政核心的总体目标，由格雷斯Y。孙先生， 博士，是通过监督和监督研究项目和核心，为PPG提供凝聚力。 这项工作包括但不限于管理预算和高成本资源， 协调应邀演讲者的访问，组织内部和外部咨询会议， 董事会，并与其他NIA资助的研究人员进行研究阿尔茨海默氏症的互动 和NIA计划官员。PPG由三个高度集成的项目和两个核心组成。具体 核心A的目标是：1）协调和监督PPG行政活动; 2）促进互动 3）组织一系列研讨会，重点关注AD和相关主题; 4）提供 5）提供紧急资金，用于设备维修或更换小型 6）为项目规划小组设计一个网站; 7）建立咨询委员会; 8）组织国家一级的 以及PPG执行委员会的国际研讨会和会议。除了部分 对人员的支持，对行政核心A的主要支持是通过大学的赠款提供的 密苏里-哥伦比亚总理基金。MU将提供资金，通过支持建立新的教育活动 研讨会发言人访问MU校园，通过组织地方，国家和国际研讨会， 将加强对AD发病机制的研究，并通过促进创新的预防策略， 和延缓疾病进展。