ADMINISTRATIVE CORE

行政核心

• 批准号: 7233109
• 负责人: BRIAN A. HERMAN
• 金额: $ 12.94万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7233109
• 关键词: Biogenesis; Biological Assay; Cell model; Cells; Complex; Consultations; Growth; Measures; Mitochondria; Mitochondrial DNA; Mitochondrial Proteins; Mitochondrial RNA; Participant; Ploidies; Principal Investigator; Production; Protein Biosynthesis; Research; Respiration; mitochondrial DNA mutation; novel strategies; programs; respiratory; respiratory enzyme; tool

Core C will serve as the Mitochondrial Function Core of the Program Project. Dr. Bai will serve as the Leader of Core C. Core C will be responsible for the following functions in the Program Project: 1. To provide tools and analytic approachesto study mitochondrial biogenesis including mitochondria! DMA content, mitochondrial RNA level, mitochondrial protein synthesis and respiratory complex assembly, and help to quantitatively detect the mitochondrial DMAmutations for all of the principal investigators of the program project who require such analysesfor the proposed studies. 2. To provide tools and approachesto analyze mitochondrialfunction including measuring total respiration, complex-dependent respiration, growth capacitywhile cells predominantly rely on mitochondria for ATP production and ATP level, and to perform respiratory enzymesassays and create mitochondrial DNA-less cell models for the principal investigators of the program projectwho require such analysesfor the proposed studies. 3. To provide consultation regarding the availability of existing and new approachesto study mitochondrial biogenesis and function to the participants of this program project and to insure the quality of relevant research conducted by the Projects and Cores.

核心C将作为该项目的线粒体功能核心。白博士将担任组长 核心C。核心C将负责计划项目中的以下职能： 1.提供研究线粒体生物发生包括线粒体的工具和分析方法！DMA 含量、线粒体RNA水平、线粒体蛋白质合成和呼吸复合体组装，以及 有助于定量检测线粒体DNA突变的所有主要研究人员的 计划项目谁需要这样的分析为拟议的研究。 2.提供工具和方法来分析呼吸功能，包括测量总呼吸， 复合物依赖呼吸，生长能力，而细胞主要依赖线粒体ATP 生产和ATP水平，并进行呼吸酶测定和创建线粒体DNA少 细胞模型的主要研究人员的计划项目谁需要这样的分析， 问题研究 3.就现有和新的线粒体研究方法的可用性提供咨询 生物起源和功能，以确保本计划项目的参与者， 由项目和核心进行的研究。