OPTICAL IMAGING CORE

核心B将作为该计划项目的光学成像和小动物成像核心。詹姆斯博士 Lechleiter是核心领导者，将负责以下工作：1）提供光学显微镜 仪器的程序项目的所有主要调查人员，特别是获得共聚焦， 多光子和整体动物成像，2）协调每个项目的努力，以纳入新的 - 诸如体内光学成像、Micro-SPECT、Micro-PET和Micro-CT的技术，以监测代谢， 衰老过程中DNA增殖、凋亡与解剖影像学的相关性; 和教育有关的理论和光学成像的应用程序的参与者 项目，以确保项目和核心进行的研究质量，4）提供计算机硬件 以及用于分析数字图像和制作出版物质量印刷品的软件。核心B将采取 的优势，仪器已经在运作中的核心光学成像设施和部门。的 UTHSCSA的放射学。通过每个组织公认的专家协调工作， 项目成员将获得最先进的光学和小动物成像仪器 从而使他们能够实施新的方法来研究活细胞，组织和整体的衰老。 动物模型

Core B will serve as the Optical Imaging and Small Animal Imaging core of the Program Project. Dr. James Lechleiter is the core leader and will be responsible for the following: 1) providing optical microscope instrumentation for all of the principle investigators of the program project, in particular access to confocal, multiphoton and whole animal imaging, 2) coordinating efforts of each project to incorporate novel techniques such as in vivo optical imaging, Micro-SPECT, Micro-PET and Micro-CT to monitor metabolism, DNA proliferation, and apoptosis with anatomic imaging correlation during aging, 3) providing consultation and education regarding the theory and application of optical imaging to the participants of the program project to insure the quality of research conducted by the projects and cores, 4) providing computer hardware and software for analysis of digital images and production of publication quality prints. Core B will take advantage of the instrumentation already in operation in the Core Optical Imaging Facility and the Dept. of Radiology at UTHSCSA. By coordinating efforts through recognized experts in each organization, Program Project members will have access to state-of-the-art instrumentation for optical and small animal imaging thus enabling them to implement novel methodologies for the study of aging in living cells, tissues and whole animal models.