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CORE--MOUSE MODELS

CORE--MOUSE MODELS
核心——小鼠模型
批准号:
7455092
负责人:
ALAN S VERKMAN
金额:
$8.75万
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-07-01 至 2010-06-30

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中文摘要
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英文摘要
The Mouse models Core will carry out breeding and genotype analysis of mice for evaluation of small-molecule CF therapies and for analysis of small-molecule pharmacology. Wildtype and homozygous CF mice (AF508, G551D, null) with defined genetic background will be generated. The Mouse models Core will also carry out potential difference (PD) measurements, and pharmacokinetic analysis of lead compounds. Wildtype mice will be provided to investigators in nine projects, and various CF mice in five projects. PD measurements (nasal, rectal, ocular) will be used by two projects, and pharmacology studies will be done for seven projects.
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