CORE--ENVIRONMENT /GENE INTERACTIONS

核心——环境/基因相互作用

• 批准号: 7392681
• 负责人: Suzie Chen
• 金额: $ 6.27万
• 依托单位: UNIV OF MED/DENT NJ-R W JOHNSON MED SCH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7392681
• 关键词: Animal Model; Animals; Appointment; Area; Chemopreventive Agent; Collaborations; Contracts; Core Facility; Detection; Development; Environmental Exposure; Environmental Risk Factor; Enzymes; Esophageal carcinoma; Funding; Future; Gene Expression Alteration; Genes; Genetic Polymorphism; Genome Stability; Genomics; Goals; Human; Immune response; Leadership; Mammals; Metabolic Biotransformation; Mutagenesis; Mutation; Names; Numbers; Peer Review Grants; Phytoestrogens; Proteomics; Regulation; Research; Research Methodology; Research Personnel; Sampling; Skin Carcinogenesis; Structure; TP53 gene; Technology; Toxic effect; U-Series Cooperative Agreements; Universities; Yeast Model System; environmental carcinogenesis; environmental chemical; falls; gene environment interaction; interest; melanoma; member; mouse model; response

Description (provided by applicant): This core was created in 1994 under the name "Biotransformation and Toxicity of Environmental Chemicals." The name was changed to Environment-Gene Interactions in April 2000, reflecting the expansion into new areas and the appointment of Dr. Suzie Chen as the Director. Dr. P. Thomas remains in the leadership of the Core as Co-Director. The core includes 16 investigators from 6 different departments at Rutgers University and 6 departments at RWJMS. The collective funding for this group of investigators is 12.8 million dollars. This number includes peer review grants, contracts, and cooperative agreements. The research interest of the core members falls into the following ten areas of research and collaboration: 1) chemopreventive activities and other dietary compounds; 2) regulation of xenobioticmetabolizing enzymes; 3) genetic polymorphisms of metabolizing enzymes Lambert; 4) detection of phytoestrogens from environmental samples; 5) P53 mutations in skin carcinogenesis; 6) mouse model for esophageal carcinoma; 7) mouse model of malignant melanoma; 8) genomic stability; 9) mutagenesis and environmental carcinogenesis; and 10) animal models. The core goals are, 1) to identify and study genes involved in cellular response to environmental exposure; 2) to characterize the alterations of the gene expression resulting from host responses to environmental factors; 3) to identify important genetic polymorphisms associated with environmental response genes; and 4) to elucidate functionally important environmental response genes in a variety of model systems, from yeast to mammals. The future plans for the core include enhancement of use of genomic and proteomic approaches, develop and increase intracore interaction and to extend studies in animal models to humans.

描述(申请人提供)：该核心创建于1994年，名称为“环境化学品的生物转化和毒性”。2000年4月更名为环境-基因相互作用，反映了新领域的扩展和陈素琪博士被任命为主任。P·托马斯博士继续担任CORE的联席主任。核心调查人员包括来自罗格斯大学6个不同系和RWJMS 6个系的16名调查人员。这组调查人员总共获得了1280万美元的资金。这一数字包括同行评审赠款、合同和合作协议。核心成员的研究兴趣包括以下十个领域：1)化学预防活性和其他饮食化合物；2)外源代谢酶的调控；3)代谢酶Lambert的遗传多态；4)从环境样本中检测植物雌激素；5)P53突变与皮肤癌；6)食道癌的小鼠模型；7)小鼠恶性黑色素瘤模型；8)基因组稳定性；9)诱变与环境致癌；10)动物模型。其核心目标是：1)识别和研究细胞对环境暴露的反应相关基因；2)表征宿主对环境因素反应引起的基因表达的变化；3)确定与环境反应基因相关的重要遗传多态；4)阐明从酵母到哺乳动物等各种模式系统中重要的环境反应基因。未来的核心计划包括加强基因组和蛋白质组方法的使用，开发和增加核心内相互作用，并将动物模型研究扩展到人类。