BLRD Research Career Scientist Award Application
BLRD 研究职业科学家奖申请
基本信息
- 批准号:10701238
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-04-01 至 2028-03-31
- 项目状态:未结题
- 来源:
- 关键词:AcademiaAmerican Association for the Advancement of ScienceAnimal ModelAppointmentAreaAutomobile DrivingAwardBasic ScienceBiological AvailabilityBiological ModelsBiologyBrainCancer Institute of New JerseyCancer PatientCancer Therapy Evaluation ProgramCell surfaceCentral Nervous SystemCharacteristicsChemicalsClinicClinicalClinical TrialsCollaborationsCommunitiesCytochrome P450DevelopmentDisciplineDiseaseEctopic ExpressionEpithelial CellsEtiologyExperimental ModelsFDA approvedFellowshipGRM1 geneGliomaGlutamatesGoalsGrantHalf-LifeHealthHumanIn VitroIndustry CollaborationInvestigationJointsKnowledgeLaboratoriesLaboratory FindingLearningLegal patentLesionLigandsLongitudinal StudiesLungMalignant NeoplasmsMalignant neoplasm of brainMedical centerMemoryMetabolismMetabotropic Glutamate ReceptorsMetastatic malignant neoplasm to brainModelingModificationMulti-Institutional Clinical TrialMusMutationNational Cancer InstituteNeoplasm MetastasisNeuronsOncogenicOrangesOrganPatient RecruitmentsPatientsPeer ReviewPennsylvaniaPharmacotherapyPharmacy SchoolsPhasePhysiciansPostdoctoral FellowProbabilityProdrugsPrognostic MarkerPropertyPublicationsRenal carcinomaResearchResearch PersonnelResearch Project GrantsResearch SupportRewardsRiluzoleRoleScientistSecureSignal PathwaySignal TransductionSiteSmall Business Innovation Research GrantSystemTechnologyTestingToxic effectTransgenic MiceTranslatingTranslational ResearchTranslationsTrusteesUniversitiesWorkamyotrophic lateral sclerosis therapyanticancer researchbiomarker identificationcareercell transformationdistinguished professordrug discoveryexperimental studyglutamatergic signalinghuman modelimprovedin vivoinnovationinter-individual variationinterestmalignant breast neoplasmmelanocytemelanomamelanomagenesismetabotropic glutamate receptor type 1molecular pathologymouse modelpre-clinicalpreventprogramsreceptorscreeningtherapeutically effectivetooltranslational applicationstranslational modeltumor
项目摘要
Mouse models reflecting human cancers are important tools towards the translation of basic science
discoveries to clinical therapies. However, rapidly evolving technologies within the last few years require
further refining current approaches that enable models to be more suitable in robust translational
applications to provide consistent information to meet patients’ needs. The focus of my first VA Merit award
was on the contributions of altered metabolisms to melanomagenesis in vitro and in vivo. Results from these
earlier studies have provided understanding and knowledge in the rational conceived strategy of our
working hypothesis for our current VA Merit. In recent years, much has been learned about the molecular
pathology of melanoma and significant progress has been made towards its treatment, yet late-stage
melanoma still remains one of the least curable cancers with high metastatic propensity. The unique
mouse models established by our group where the ectopic expression of a normal neuronal receptor,
metabotropic glutamate receptor (GRM1), in normal melanocytes leads to consistent, wide-spread
development of melanocytic lesions and metastasis to various organs including the lung and brain, two
common metastatic sites for human melanoma. Our focus is to take advantage of the innovative model
that mimic human melanoma with brain metastases to expand, improve, and transform the utility of
mammalian tumor models for translational research. Completion of our proposed investigation is an essential
step towards establishing fundamentally important and relevant animal models of human cancer that will
improve and save cancer patient lives.
反映人类癌症的小鼠模型是基础科学转化的重要工具
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Suzie Chen其他文献
Suzie Chen的其他文献
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{{ truncateString('Suzie Chen', 18)}}的其他基金
Translational application of mouse models of melanoma brain metastases
黑色素瘤脑转移小鼠模型的转化应用
- 批准号:
10371885 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Translational application of mouse models of melanoma brain metastases
黑色素瘤脑转移小鼠模型的转化应用
- 批准号:
10620161 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Regulation of tumor released exosomes and glutamatergic signaling
肿瘤释放的外泌体和谷氨酸信号传导的调节
- 批准号:
8813433 - 财政年份:2014
- 资助金额:
-- - 项目类别:
CORE--MOLECULAR GENETICS AND TRANSGENETICS FACILITY
核心——分子遗传学和转基因设施
- 批准号:
6585561 - 财政年份:2002
- 资助金额:
-- - 项目类别:
相似海外基金
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Standard Grant
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7826796 - 财政年份:1978
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Standard Grant
SCIENCE '71- A REPORT TO THE NATION AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE
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- 批准号:
7251454 - 财政年份:1972
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