Molecular and Cellular Toxicology

分子和细胞毒理学

• 批准号: 7496895
• 负责人: RAYMOND F NOVAK
• 金额: $ 9.93万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7496895
• 关键词: Apoptosis; Applications Grants; Area; Asthma; Award; Bioinformatics; Camping; Categories; Childhood; Chlorinated Hydrocarbons; Collaborations; Communication; Communities; Community Outreach; Computer Analysis; Computer software; Core Facility; Cost Sharing; Cultured Cells; Curiosities; Diabetes Mellitus; Disease; Education; Education and Outreach; Educational Curriculum; Electronic Mail; Environmental Epidemiology; Environmental Health; Equipment; Etiology; Faculty; Fertilization; Functional disorder; Funding; Funding Opportunities; Future; Gene Expression; Gene Expression Regulation; Genetic; Genetic Polymorphism; Genomics; Goals; Grant; Growth; Growth and Development function; Hepatic; Human; Human Resources; Hygiene; Image Cytometry; Incentives; Individual; Inflammation; Information Dissemination; Institutes; Interdisciplinary Study; Internet; Intervention; Investments; Knowledge; Leadership; Malignant Neoplasms; Metabolic Diseases; Michigan; Molecular; Mutation; Neurofibromatosis 1; Operative Surgical Procedures; Particulate; Personnel Staffing; Photochemotherapy; Physicians; Pilot Projects; Population; Positioning Attribute; Proteins; Proteomics; Publications; Range; Research; Research Activity; Research Personnel; Research Proposals; Resources; Role; Schools; Science; Scientist; Score; Series; Services; Signal Transduction; Site; Solvents; Structural Biologist; Students; Support of Research; Technology; Toxicology; Training; Translational Research; Universities; Update; atopy; college; continuing medical education; environmental agent; genetic association; high school; interest; member; nervous system disorder; novel; programs; reproductive; symposium; teacher

A competitive renewal is submitted for the EHS Center in "Molecular and Cellular Toxicology with Human Applications" headquartered in the Institute of Environmental Health Sciences (IEHS) at Wayne State University (WSU). The focus of the Center is the stimulation of collaborative interdisciplinary, multidisciplinary research employing contemporary molecular, cellular, genomic and proteomic approaches to the study of environmental agent (e.g. organochlorines/PAH/solvents and particulates; major urban/Southeastern Michigan concerns) effects on gene expression, cell signaling and function, and human populations. Disease emphasis includes asthma, hepatic dysfunction in metabolic diseases (e.g. diabetes, inflammation, dislipidemias), reproductive and neurological disorders, and cancer. Progress includes 12 multi-investigator grants ($43 M), numerous collaborative grants, 93 collaborative and 411 total publications, research integrating population and bench scientists, and institutional investment. The EHS Center consists of an Administrative Core, three Research Cores, four Facility Cores, a COEP, a Pilot Project Program and an Enrichment Program. The Research Cores, "Gene Regulation and Genetics", "Cell Signaling and Function" and "Environmental Epidemiology", contain 43 faculty from three schools/colleges, three centers and five departments. The "Cell Culture", "Imaging and Cytometry", "Microarray and Bioinformatics" and "Protein Interaction and Proteomics" Facility Cores exist in dedicated space with assigned personnel to support research. The Microarray and Bioinformatics Facility Core includes Agilent and ABI equipment, Sun computers, analysis software (e.g. Rosetta Resolver(R) and bioinformatics expertise to assist with global gene expression analysis and the association of genetic factors (i.e. SNPs (polymorphisms), mutations) with disease. A Protein Interaction and Proteomics Facility Core has been initiated with the purchase of major equipment. An active COEP, with emphasis on K-12 education, has been developed and includes K-12 curricula, science camps, competitive science awards, high school teacher training, and dissemination of information to the community. The Pilot Project Program contains escalating incentive funding for collaborative, interdisciplinary, multidisciplinary research proposals; supplemental funds for scored, not funded, grants may be provided. Professional growth is stimulated through an Enrichment Program (i.e. a seminar series and an Annual Thematic Symposium offering Category I Continuing Medical Education credits). Institutional commitment is shown by the hierarchal position of the IEHS in WSU, by assigned tenure track positions, by approximately $1,000,000 in equipment purchases, and by past (approximately $240,000) and future cost sharing of the Pilot Project Program (approximately $300,000). The EHS Center, reviewed annually by the External Advisory Board, provides Center Members with the opportunity and resources for collaborative interdisciplinary/multidisciplinary research, involving bench scientists, bioinformaticists, structural biologists, population scientists, physician-scientists and graduate students, to examine the role of environmental agents in disease.

为总部设在韦恩州立大学(WSU)环境健康科学研究所(IEHS)的“分子和细胞毒理学与人类应用”EHS中心提交了一份竞争性续签申请。该中心的重点是促进跨学科、多学科的协作研究，利用当代分子、细胞、基因组和蛋白质组学方法研究环境制剂(例如，有机氯/多环芳烃/溶剂和颗粒物；密歇根州主要城市/东南部问题)对基因表达、细胞信号和功能以及人类种群的影响。疾病重点包括哮喘、代谢性疾病中的肝功能障碍(如糖尿病、炎症、血脂紊乱)、生殖和神经障碍以及癌症。进展包括12名多调查员赠款(4,300万美元)、众多协作性赠款、93项协作性赠款 以及411篇出版物、整合人口和板凳科学家的研究以及机构投资。EHS中心由一个行政核心、三个研究核心、四个设施核心、一个COEP、一个试点项目方案和一个浓缩方案组成。研究的核心是“基因调控和遗传学”、“细胞信号和功能”和“环境流行病学”，包括来自三所学校/大学、三个中心和五个系的43名教职员工。这个 “细胞培养”、“成像和细胞计量学”、“微阵列和生物信息学”和“蛋白质相互作用和蛋白质组学”设施的核心存在于专门的空间，并指派人员支持研究。微阵列和生物信息学设施核心包括安捷伦和ABI设备、太阳计算机、分析软件(例如Rosetta Resolver(R))和生物信息学专业知识，以帮助进行全球基因表达分析和遗传因素(即SNP)的关联 (多态)、突变)与疾病有关。通过购买主要设备，已经启动了蛋白质相互作用和蛋白质组学设施核心。现已制定了一项以K-12教育为重点的积极的CoEP，其中包括K-12课程、科学夏令营、竞争性科学奖、高中教师培训以及向社区传播信息。试点项目计划包含不断增加的奖励资金，用于协作、跨学科、多学科的研究提案；针对已评分的、非资助的补充资金可能是 如果是这样的话。专业成长是通过丰富计划(即系列研讨会和提供I类继续医学教育学分的年度主题研讨会)来刺激的。机构承诺体现在IEHS在华盛顿大学的等级地位、分配的任期跟踪职位、设备采购方面的约1,000,000美元，以及试点项目计划的过去(约240,000美元)和未来的成本分担(约300,000美元)。EHS中心由外部咨询委员会每年进行审查，为中心成员提供跨学科/多学科合作研究的机会和资源，包括长凳科学家、生物信息学家、结构生物学家、人口学家、内科科学家和研究生，以研究环境因素在疾病中的作用。