Molecular and Cellular Toxicology

分子和细胞毒理学

• 批准号: 7048500
• 负责人: RAYMOND F NOVAK
• 金额: $ 153.39万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7048500
• 关键词: clinical research; environmental toxicology; human subject

A competitive renewal is submitted for the EHS Center in "Molecular and Cellular Toxicology with Human Applications" headquartered in the Institute of Environmental Health Sciences (IEHS) at Wayne State University (WSU). The focus of the Center is the stimulation of collaborative interdisciplinary, multidisciplinary research employing contemporary molecular, cellular, genomic and proteomic approaches to the study of environmental agent (e.g. organochlorines/PAH/solvents and particulates; major urban/Southeastern Michigan concerns) effects on gene expression, cell signaling and function, and human populations. Disease emphasis includes asthma, hepatic dysfunction in metabolic diseases (e.g. diabetes, inflammation, dislipidemias), reproductive and neurological disorders, and cancer. Progress includes 12 multi-investigator grants ($43 M), numerous collaborative grants, 93 collaborative and 411 total publications, research integrating population and bench scientists, and institutional investment. The EHS Center consists of an Administrative Core, three Research Cores, four Facility Cores, a COEP, a Pilot Project Program and an Enrichment Program. The Research Cores, "Gene Regulation and Genetics", "Cell Signaling and Function" and "Environmental Epidemiology", contain 43 faculty from three schools/colleges, three centers and five departments. The "Cell Culture", "Imaging and Cytometry", "Microarray and Bioinformatics" and "Protein Interaction and Proteomics" Facility Cores exist in dedicated space with assigned personnel to support research. The Microarray and Bioinformatics Facility Core includes Agilent and ABI equipment, Sun computers, analysis software (e.g. Rosetta Resolver(R) and bioinformatics expertise to assist with global gene expression analysis and the association of genetic factors (i.e. SNPs (polymorphisms), mutations) with disease. A Protein Interaction and Proteomics Facility Core has been initiated with the purchase of major equipment. An active COEP, with emphasis on K-12 education, has been developed and includes K-12 curricula, science camps, competitive science awards, high school teacher training, and dissemination of information to the community. The Pilot Project Program contains escalating incentive funding for collaborative, interdisciplinary, multidisciplinary research proposals; supplemental funds for scored, not funded, grants may be provided. Professional growth is stimulated through an Enrichment Program (i.e. a seminar series and an Annual Thematic Symposium offering Category I Continuing Medical Education credits). Institutional commitment is shown by the hierarchal position of the IEHS in WSU, by assigned tenure track positions, by approximately $1,000,000 in equipment purchases, and by past (approximately $240,000) and future cost sharing of the Pilot Project Program (approximately $300,000). The EHS Center, reviewed annually by the External Advisory Board, provides Center Members with the opportunity and resources for collaborative interdisciplinary/multidisciplinary research, involving bench scientists, bioinformaticists, structural biologists, population scientists, physician-scientists and graduate students, to examine the role of environmental agents in disease.

提交了EHS中心“分子和细胞毒理学与人类应用”的竞争性更新，该中心总部位于韦恩州立大学（WSU）环境健康科学研究所（IEHS）。该中心的重点是激励合作跨学科，多学科研究采用当代分子，细胞，基因组学和蛋白质组学方法研究环境因子（例如有机氯/PAH/溶剂和颗粒物;主要城市/密歇根州东南部关注）对基因表达，细胞信号传导和功能以及人群的影响。疾病重点包括哮喘、代谢性疾病中的肝功能障碍（例如糖尿病、炎症、糖尿病）、生殖和神经系统疾病以及癌症。进展包括12个多研究者赠款（4300万美元），许多合作赠款，93个合作赠款， 和411总出版物，研究整合人口和板凳科学家，和机构投资。EHS中心由一个行政核心，三个研究核心，四个设施核心，一个COEP，一个试点项目计划和一个浓缩计划组成。研究核心，“基因调控和遗传学”，“细胞信号传导和功能”和“环境流行病学”，包括来自三所学校/学院，三个中心和五个部门的43名教师。的 “细胞培养”、“成像和细胞计数”、“微阵列和生物信息学”以及“蛋白质相互作用和蛋白质组学”设施核心位于专用空间，并配备人员支持研究。微阵列和生物信息学设施核心包括Agilent和ABI设备、Sun计算机、分析软件（例如Rosetta Resolver）和生物信息学专业知识，以帮助进行全局基因表达分析和遗传因子（即SNP）的关联 （多态性），突变）与疾病。购买了主要设备，启动了蛋白质相互作用和蛋白质组学核心设施。已经制定了一个积极的COEP，重点是K-12教育，包括K-12课程、科学营、竞争性科学奖、高中教师培训和向社区传播信息。试点项目计划包含不断升级的奖励资金，用于合作，跨学科，多学科的研究提案;补充资金用于评分，而不是资助，赠款可能是 提供了专业成长是通过一个丰富的计划（即系列研讨会和年度专题研讨会提供第一类继续医学教育学分）刺激。机构的承诺是由IEHS在WSU的层次位置，由指定的任期跟踪位置，由约100万美元的设备采购，并通过过去（约240,000美元）和未来的试点项目计划（约300,000美元）的成本分摊。EHS中心每年由外部咨询委员会审查，为中心成员提供跨学科/多学科合作研究的机会和资源，涉及板凳科学家，生物信息学家，结构生物学家，人口科学家，医生科学家和研究生，以研究环境因子在疾病中的作用。