The magic of blood: shining light on chemistry, physics and bioengineering

血液的魔力：照亮化学、物理和生物工程

• 批准号: EP/F057709/1
• 负责人: Christopher Cooper
• 金额: $ 23.33万
• 依托单位: University of Essex
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FF057709%2F1
• 关键词: magic; blood; shining; light; chemistry

Areas to be coveredThis project aims to promote the role of research funded by EPSRC, particularly that at the Life Science Interface. Three areas will be covered. 1 The initial focus will be on issues relating to the chemistry and physics of blood. Blood is a fluid involved in oxygen transport and host defence against disease. However, its colour and magnetic properties makes it accessible to a wide range of physical techniques. A key story will be the use of the optical properties of blood as a probe in medicine and sport, the purpose of two current EPSRC grants by the PI. Bioengineering the blood itself to make a safer and more long-lasting alternative to blood transfusions / so-called blood substitutes / will also be featured. 2 The use of illegal drugs in sport is a contentious and continually evolving media story. It provides an ideal environment within which basic ideas of chemistry and physics can be communicated to a mass audience. Furthermore EPSRC funds a large number of grants in sports science, partly, but not entirely, in response to the London 2012 Olympics bid. These are fertile ground for the media and I would be interesting in assisting other EPSRC scientists in developments outside my immediate research area, using any contacts I have built up. 3 The environmental pollutant nitric oxide is now known to play a key role in normal bodily functions, as well as disease. Nitric oxide's influence ranges from killing bacteria to controlling penile erections (Viagra acts on the nitric oxide pathway). The PI has research interests in the chemistry and biology of nitric oxide, including developing mathematical and computational models to describe its effects on brain and muscle function. StrategyThe overall strategy will make use of the saleability of sport and medicine to the mass media, using these as Trojan Horses to explain chemical and physical principles underpinning current research. TacticsThe tactics will first be to use current and future book projects (blood, drugs in sport, nitric oxide) to create a profile against which to launch proposals for television and radio documentaries. Especially for TV work, it is key to create evocative visual images and an important part of the project will be filming studies (in chemistry, physics or sport), creating taster tapes that can be used to pitch programs.Further media responses to work already produced will be followed up and I will reactively respond to print media stories in these areas. Because of this, considerable flexibility will be built into the project. So for example if a TV or radio documentary series was commissioned about blood or sports science it would be counter-productive to initiate a book writing project on nitric oxide in that year.

本项目旨在促进EPSRC资助的研究的作用，特别是在生命科学接口方面。将涵盖三个领域。1最初的重点将是与血液的化学和物理学有关的问题。血液是一种参与氧气运输和宿主防御疾病的液体。然而，它的颜色和磁性使它可以用于各种物理技术。一个关键的故事将是使用血液的光学特性作为医学和体育的探针，这是PI目前两项EPSRC赠款的目的。生物工程血液本身，使一个更安全和更持久的替代输血/所谓的血液替代品/也将特色。2在体育运动中使用非法药物是一个有争议的和不断演变的媒体故事。它提供了一个理想的环境，在其中化学和物理的基本思想可以传达给广大观众。此外，EPSRC为体育科学提供了大量赠款，部分但不完全是为了响应伦敦2012年奥运会的申办。这些都是媒体的沃土，我会很有兴趣在我直接研究领域之外的发展中帮助其他EPSRC科学家，利用我建立的任何联系。3现在已知环境污染物一氧化氮在正常的身体功能以及疾病中起着关键作用。一氧化氮的影响范围从杀死细菌到控制阴茎勃起（伟哥作用于一氧化氮途径）。PI对一氧化氮的化学和生物学有研究兴趣，包括开发数学和计算模型来描述其对大脑和肌肉功能的影响。总体战略将利用体育和医学对大众媒体的宣传，利用这些宣传作为特洛伊木马来解释支撑当前研究的化学和物理原理。策略策略将首先使用当前和未来的图书项目（血液，体育药物，一氧化氮）创建一个配置文件，根据该配置文件启动电视和广播纪录片的建议。特别是对于电视作品来说，创造令人回味的视觉图像是关键，项目的一个重要部分将是拍摄研究（化学，物理或体育），制作可以用于推销节目的品尝磁带。媒体对已经制作的作品的进一步反应将被跟进，我将对这些领域的印刷媒体故事做出反应。因此，该项目将具有相当大的灵活性。因此，例如，如果一个电视或广播纪录片系列是关于血液或运动科学的，那么在那一年发起一本关于一氧化氮的书的写作项目将适得其反。

项目成果

Drug cheating at the Olympics: who, what, and why?

奥运会上的毒品作弊：谁、什么、为什么？

• DOI: 10.1016/s0140-6736(12)61114-3
• 发表时间: 2012
• 期刊: Lancet (London, England)
• 作者: Cooper C

Run, Swim, Throw, Cheat: The science behind drugs in sport

跑步、游泳、投掷、作弊：运动中药物背后的科学

• 发表时间: 2012
• 作者: Cooper

Blood: A Very Short Introduction

血液：非常简短的介绍

• 发表时间: 2016
• 作者: Cooper