2008 Calcium Signaling and Disease SGP Conference

描述(由申请者提供)：本提案请求资金支持将于2008年9月3-7日在马萨诸塞州伍兹霍尔海洋生物实验室举行的“钙信号与疾病”国际研讨会。本次会议将是第62届全科生理学家学会(SGP)年会。SGP的主要目的是每年举办一次研讨会，讨论细胞生物学家、生理学家和生物物理学家广泛感兴趣的不同主题。为2008年会议选择的议题特别及时和引人注目。以前的SGP会议(1986年和1998年)都集中在举行这些会议时的尖端钙信号研究。在计划2008年的会议时，很明显，最近钙信号领域的爆炸性发展首次将重点放在了以疾病为导向的研究上。虽然许多钙信号会议都包含一个“疾病”会议，但我们的研讨会将是美国第一次专门关注钙信号病理方面的会议。在选择我们的计划时，我们把重点放在了几个关键的研究领域，在这些领域，进展最显著，获得的线索也最诱人。这些疾病包括：(1)心脏和骨骼肌疾病(心律失常、猝死综合征、恶性高热和肌营养不良)，(2)神经退行性疾病(阿尔茨海默病、亨廷顿病和帕金森病)，(3)中枢神经系统疾病(家族性偏头痛和自闭症)，(4)与钙泵功能障碍有关的疾病(耳聋、Darier和Hailey-Hailey病)，(5)与Trp通道家族功能障碍有关的疾病(多囊肾病、低镁血症、不孕症和糖尿病)。这些主题代表了跨越几个医学子专业的与疾病相关的项目的独特混合，但由于其对钙离子信号的关注而统一。我们预计，这次会议将吸引大量致力于钙信号转导的科学家，也将吸引一些临床科学家和以前从未接触过尖端钙信号研究的面向疾病的基础研究人员。我们希望通过促进传统的“钙信号转导研究人员”和“疾病研究人员”之间的交流，我们的会议将在加速该领域的进展并将其转化为临床见解和实践方面发挥重要作用。由普通生理学家协会组织的会议似乎是促进转化性生物医学研究中这种关键发展的理想准备。与公共健康相关：这项提案要求资金帮助支持将于2008年9月3-7日在马萨诸塞州伍兹霍尔海洋生物实验室举行的关于“钙信号与疾病”的国际研讨会。本次会议将是第62届全科生理学家学会(SGP)年会。SGP的主要目的是每年举办一次研讨会，讨论细胞生物学家、生理学家和生物物理学家广泛感兴趣的不同主题。

DESCRIPTION (provided by applicant): This proposal requests funds to help support an international symposium on "Calcium signaling and disease" to be held September 3 - 7, 2008, at the Marine Biological Laboratory in Woods Hole, Massachusetts. This meeting will be the 62nd Annual Symposium of the Society of General Physiologists (SGP). The major purpose of the SGP is to host a symposium each year on a different subject of wide interest to cell biologists, physiologists and biophysicists. The topic chosen for the 2008 meeting is especially timely and compelling. The previous SGP meetings (in 1986 and 1998) were focused on the cutting-edge Ca2+ signaling research at the time when those meetings were held. In planning the 2008 meeting, it became clear that recent explosive developments in the area of Ca2+ signaling for the first time actually placed a focus on disease-oriented research within reach. Although many Ca2+ signaling meetings incorporated a "disease" session, our symposium will be the first in the U.S. focused exclusively on pathological aspects of Ca2+ signaling. In selecting our program we focused on several key areas of research where the progress has been most dramatic, and the obtained clues most tantalizing. These areas are: (1) cardiac and skeletal muscle diseases (arrhythmia, sudden death syndrome, malignant hyperthermia and muscular dystrophy), (2) neurodegenerative disease (Alzheimer's, Huntington's, and Parkinson's); (3) disorders of the central nervous system (familial migraine and autism); (4) disorders linked to dysfunction of Ca2+ pumps (deafness, Darier and Hailey-Hailey disease); (5) disorders linked to dysfunction of the trp channel family (polycystic kidney disease, hypomagnesaemia, infertility and diabetes). These topics represent a unique blend of disease-related projects spanning several medical subspecialties but unified by their focus on Ca2+ signaling. We expect that this conference will attract a significant number of scientists working on Ca2+ signaling but also a number of clinical scientists and disease- oriented basic researchers who have not been exposed to cutting edge Ca2+ signaling research previously. We hope that by promoting an exchange between traditional "Ca2+ signaling researchers" and "disease researchers" our meeting will play an important role in accelerating progress in the field and its translation into clinical insights and practice. The meetings organized by the Society of General Physiologists seem to be ideally poised to facilitate such critical developments in translational biomedical research. PUBLIC HEALTH RELEVANCE: This proposal requests funds to help support an international symposium on "Calcium signaling and disease" to be held September 3 - 7, 2008, at the Marine Biological Laboratory in Woods Hole, Massachusetts. This meeting will be the 62nd Annual Symposium of the Society of General Physiologists (SGP). The major purpose of the SGP is to host a symposium each year on a different subject of wide interest to cell biologists, physiologists and biophysicists.