2007 Endothelial Phenotypes in Health and Disease Gordon Research Conference

2007 年健康与疾病中的内皮表型戈登研究会议

• 批准号: 7483407
• 负责人: Thomas O Daniel
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7483407
• 关键词: Academy; Acute Lung Injury; Atherosclerosis; Biology; Blood - brain barrier anatomy; Blood Vessels; Cardiology; Cell Line; Cellular biology; Clinical; Dermatology; Developmental Biology; Diabetes Mellitus; Discipline; Discipline of obstetrics; Disease; Endothelial Cells; Endothelium; Fibrosis; Gastroenterology; Genomics; Goals; Health; Hematology; Hemolytic-Uremic Syndrome; Hemostatic function; Human; Immunology; Inflammation; Liver Circulation; Lung; Maine; Mathematics; Mediating; Modality; Natural Immunity; Nature; Nephrology; Neurology; Neurosciences; New England; Nonlinear Dynamics; Ophthalmology; Organ; Organism; Participant; Phenotype; Placenta; Play; Process; Proteomics; Pulmonary Hypertension; Pulmonology; Range; Research; Research Personnel; Role; Scientist; Sepsis; Sickle Cell Anemia; Sorting - Cell Movement; Stem cells; Structure; Testing; Therapeutic; Time; Tissues; Today; Transplantation; Universities; Vascular Diseases; Veno-Occlusive Disease; abstracting; interest; oncology; precursor cell; success; symposium; tumor

DESCRIPTION (provided by applicant): The 2008 Endothelial Cell Phenotypes in Health and Disease Gordon Research Conference will be held August 3-8, 2008 at the University of New England, Biddeford, Maine. The overall goal of this "Endothelial Phenotypes in Health and Disease" Gordon Research Conference is to bring together scientists from diverse fields who share a common interest in understanding the role of endothelial cell phenotypes in health and disease. The topics covered provide a convergent interaction for investigators from such diverse fields as vascular biology, hematology (hemostasis, endothelial precursor cells, circulating endothelial cells, sickle cell disease), sepsis (innate immunity), oncology (tumor endothelium), pulmonary (pulmonary hypertension, acute lung injury), obstetrics (placenta), nephrology (hemolytic uremic syndrome), neurology (blood brain barrier), gastroenterology (liver circulation, veno-occlusive disease), developmental biology, and nonlinear dynamics/mathematics. At the present time, there is no other well-established venue for this sort of cross-disciplinary interaction between these various groups. The endothelial cells (EC) that line the interconnected vascular network supplying every organ are highly specialized and heterogeneous in structure and function. The EC network establishes and maintains a dynamic dialogue with the underlying tissues it supplies, integrating the mobile intravascular compartment within specialized vascular structures that define organ function in health, and that mediate critical aspects of pathological disease processes, ranging from inflammation to atherosclerosis to fibrosis. Thus, the integrated structure and function of endothelial cells extends far beyond the traditional organ focused disciplines of cardiology, hematology and pulmonary medicine. The endothelium, in traversing each and every organ, establishes a dialogue that is unique to the underlying tissue. The endothelial-tissue interface plays an important role not only in maintaining health of the organism, but also in dictating the focal nature of vascular disease states. Viewed from this perspective, the endothelium transects across a spectrum of clinical disciplines. While twenty years ago, one was hard pressed to identify a single disease in which the endothelium played a prominent role, today, it may be argued that virtually every disease involves the endothelium, either as a primary determinant of disease or as a victim of collateral damage. Until the formation of this Gordon Conference in 2004, the field had no formal venue for interdisciplinary interactions. The inaugural "Endothelial Phenotypes in Health and Disease" conference was held at Proctor Academy, NH August 22-27, 2004. The second session was held at the University of New England, ME on August 3-8, 2006. Both were resounding successes, as viewed by attendance and participant reviews following the conferences. The overall goal of the third conference, like its predecessors, is to bring together scientists from diverse fields to define the role of endothelial cell phenotypes in health and disease, in order to advance the field, and to create therapeutic hypotheses that can be tested with emerging therapeutic modalities. The fields include developmental biology, immunology, non-linear dynamics, genomics, proteomics, hematology, oncology, pulmonary, cardiology, ophthalmology, dermatology, placental biology, gastroenterology, neuroscience, nephrology, transplant biology, stem cell biology and diabetes. This integrative effort promises to advance human health and to serve the objectives of the NHLBI. (End of Abstract)

描述（由申请人提供）： 2008年健康和疾病中的内皮细胞表型戈登研究会议将于2008年8月3日至8日在缅因州比德福德的新英格兰大学举行。 这个“健康和疾病中的内皮细胞表型”戈登研究会议的总体目标是汇集来自不同领域的科学家，他们在了解内皮细胞表型在健康和疾病中的作用方面有着共同的兴趣。所涵盖的主题为来自血管生物学、血液学、（止血、内皮前体细胞、循环内皮细胞、镰状细胞病）、败血症（先天免疫），肿瘤学（肿瘤内皮），肺（肺动脉高压、急性肺损伤）、产科（胎盘）、肾脏学（溶血性尿毒综合征）、神经学（血脑屏障）、胃肠病学（肝循环、静脉闭塞性疾病）、发育生物学和非线性动力学/数学。目前，这些不同群体之间没有其他固定的跨学科互动场所。 内皮细胞（EC）排列在相互连接的血管网络中，供应每个器官，在结构和功能上是高度特化和异质的。EC网络建立并维持与其供应的底层组织的动态对话，将移动的血管内隔室整合在专门的血管结构内，所述专门的血管结构限定健康中的器官功能，并且介导病理疾病过程的关键方面，从炎症到动脉粥样硬化到纤维化。因此，内皮细胞的整体结构和功能远远超出了心脏病学、血液学和肺医学的传统器官集中学科。 内皮细胞在穿越每一个器官的过程中，建立了一种与底层组织独特的对话。内皮-组织界面不仅在维持生物体的健康方面起重要作用，而且在决定血管疾病状态的病灶性质方面也起重要作用。从这个角度来看，内皮横切一系列临床学科。20年前，人们很难确定内皮在其中发挥重要作用的单一疾病，而今天，可以认为几乎每种疾病都涉及内皮，无论是作为疾病的主要决定因素还是作为附带损害的受害者。直到2004年戈登会议的形成，该领域没有跨学科互动的正式场所。 首届“健康和疾病中的内皮表型”会议于2004年8月22-27日在新罕布什尔州普罗克特学院举行。第二届会议于2006年8月3日至8日在新英格兰大学举行。从会议后的出席情况和与会者审查来看，这两次会议都取得了巨大成功。与历届会议一样，第三届会议的总体目标是汇集来自不同领域的科学家，定义内皮细胞表型在健康和疾病中的作用，以推进该领域的发展，并创建可以测试的治疗假设。与新兴的治疗方式。这些领域包括发育生物学、免疫学、非线性动力学、基因组学、蛋白质组学、血液学、肿瘤学、肺、心脏病学、眼科学、皮肤病学、胎盘生物学、胃肠病学、神经科学、肾脏学、移植生物学、干细胞生物学和糖尿病。这一综合努力有望促进人类健康，并为《国家卫生法》的目标服务。(End摘要）