Administrative

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primarily by Dr. Holtzman and Dr. Senior) will provide scientific and administrative direction for all aspects of the SCCOR program as noted above. In particular, direction is critical for maintaining communication among SCCOR investigators to facilitate interaction and rapid translation of basic science observations to clinical research protocols. PHS 398/2590 (Rev. 09/04) Page 411 Continuation Format Page Core A: Holtzman, Michael J. Principal Investigator/Program Director (Last, First, Middle): Holtzman, Michael J. 2. Advisory committee The Core will coordinate an annual meeting with the Internal Advisory Committee in which SCCOR progress is presented and critically reviewed. We selected an internal (versus external) committee for two main reasons: (1) the local administrative talent (Department Heads of SCCOR member DepartmentsCell Biology/Physiology, Genetics, Medicine, Pathology/Immunology, Pediatrics, Physics, and Radiology) are also outstanding scientists and immunologists and so are ideally suited to advise the SCCOR program; and (2) we wanted to maintain flexibility in our choice of outside advisors so that a standing committee was considered less desirable than ad hoc consultants. 3. Consultants The Core will also coordinate visits from external consultants listed in the project and core proposals. As noted above, we opted to use this mechanism for external advice (rather than an external advisory committee) to allow for flexibility in consultant selection as SCCOR research progresses. 4. Budget support The core will be responsible for management of all budgets and for monitoring expenditures for SCCOR investigators. Each investigator will receive a monthly statement detailing the financial activity of their project. Orders for supplies and equipment are placed using an on-line computer service that facilitates cost accounting. The core will also be responsible for maintaining records in response to internal and external audits of SCCOR activities. 5. Personnel support The Core will be responsible for initiating all contact with the University department for human resources and for handling issues related to employment status and job benefits. 6. Manuscript preparation The core will provide assistance in preparing manuscripts and will coordinate activities related to publication of SCCOR data. In addition, the Core will be responsible for maintaining a computer-based reference library for use in manuscript preparation and searches relevant to SCCOR projects. 7. Progress reports and other correspondence The core will be responsible for facilitating preparation of all progress reports. In addition, core personnel will prepare and/or facilitate any correspondence of SCCOR investigators with their collaborators. 8. Approval for human and animal use The core will maintain all human and animal use approvals and will facilitate renewal of approvals on an annual basis. 9. Information handling The core will assist in computer-based literature searches and will provide facilities and personnel for data presentation (including computer-based presentations and photocopying for overhead projection) as well as for color and black and white photocopying. Publication costs are incorporated into budgets for individual projects. 10. Computer support and electronic communication This component (provided primarily by Mr. Vogelgesang) will provide all support for computer services for the SCCOR program. A primary goal of this support is to maintain electronic linkage for all SCCOR investigators with each other and with their collaborators/colleagues. The current system takes advantage of local electronic mail interfaced to other Departments and to other services off-