Clinical Infrastructure

临床基础设施核心是SCCOR提案中不可或缺的组成部分。它是以非常具体的方式为每个项目服务的统一纽带，为DNA分析和各种生化测定提供血液。同样重要的是，临床基础设施核心收集、整理、归档和检索所有临床数据，从而将每个科学分析与关键临床信息相匹配。此外，临床基础设施核心负责招募患者、对照和独特的家庭进行纵向研究。它还负责对这些患者及其家属进行系统的跟踪。事实上，这是一项艰巨的任务，需要与患者、家属、医生、研究护士、科学家、 IRB和管理员。数以千计的样本将被获取、存储、检索和分析。将生成和维护一个非常大的临床、人口学、心血管造影术、心电图学和超声心动图资料数据库。克利夫兰诊所的团队已经在现场组建了这样一个组织，形式是GeneBank和GeneQuest。我们现在在这两个大型和重要的数据存储库方面已经有了几年的经验，并得到了强有力的机构支持。我们有空间和一大批研究干部护士、计算机、技术人员和一些医生来操作这项劳动密集型的工作 基础设施。随着时间的推移，它的操作方面有所改善，关于基因和冠状动脉疾病的重要新数据目前正在涌现。我们现在有机会与SCCOR一起扩大我们的研究目标，并进一步将我们数据库中的临床表型信息与冠状动脉疾病的遗传和分子病理生理学联系起来。临床基础设施核心显然是实现这一目标的关键。我们相信，在加里·弗朗西斯博士和斯蒂芬·埃利斯博士以及我们众多敬业人员的干练领导下，我们可以利用我们在GeneBank和GeneQuest方面的独特经验，专注于新的和紧密的 综合SCCOR项目，旨在探索和更好地了解冠状动脉疾病的遗传学。

The Clinical Infrastructure Core is an indispensable component of the SCCOR proposal. It is the unifying link that serves each Project in a very specific manner by providing blood for DNA analysis and assorted biochemistry determinations. Just as importantly, the Clinical Infrastructure Core collects, collates, files and retrieves all clinical data, thereby matching each scientific analysis to key clinical information. Moreover, the Clinical Infrastructure Core is responsible for recruiting patients, controls, and unique families for longitudinal study. It is also responsible for the systematic follow-up of these patients and their families. In reality, this is an enormous task, requiring the multiple interactions with patients, families, physicians, research nurses, scientists, IRBs and administrators. Thousands of samples will be acquired, stored, retrieved and analyzed. An exceptionally large database of clinical, demographic, angiographic, electrocardiographic and echocardiographic material will be generated and maintained. The group at the Cleveland Clinic has already assembled such an organization on site in the form of GeneBank and GeneQuest. We have now several years of experience with these two large and important data repositories, generously maintained by strong institutional support. We have space and a large cadre of research nurses, computers, technicians and some physicians to operate this labor-intensive infrastructure. Over time, its operational aspects have improved, and important new data on genes and coronary artery disease are currently emerging. We now have an opportunity with the SCCOR to expand our research goals and further link our clinical phenotype information in the data banks to the genetic and molecular pathophysiology of coronary artery disease. The Clinical Infrastructure Core is clearly essential to this end. We believe that under the able leadership of Drs. Gary Francis and Stephen Ellis and our many dedicated personnel, that we can leverage our unique experience with GeneBank and GeneQuest to focus on new and tightly integrated SCCOR projects designed to explore and better understand the genetics of coronary artery disease.