Translational Science

核心一：转化科学 翻译科学中心成立于2002年。这一核心的目的是促进 塔夫茨大学的CFAR研究人员开发和实施新的临床/转化HIV研究 和布朗以及在国际网站。核心应对CFAR流行病演变为 越来越复杂的综合征，需要将基础和临床研究扩展到转化研究 能够检查基础研究的临床意义，并确定 临床研究中的观察结果。核心基金的供资使跨学科研究得以发展， 这些研究本来不会得到支持，并招募了优秀的新研究人员来启动艾滋病毒 相关研究项目。该中心提供的服务多种多样，并导致了 一组不同的研究。 该核心的主要目标是： 1.特别支持调查人类免疫缺陷病毒感染（病毒性 病毒负荷、病毒类型和病毒感染诱导的炎症变化）对临床结果的影响 包括抵抗力的发展，以及代谢和体型变化的发展（HIV相关 脂肪营养不良）。 2.支持艾滋病毒并发症及其治疗方法的转化研究，包括结核病， 隐孢子虫感染和抗逆转录病毒药物毒性等肠道疾病。 3.支持翻译研究，发展必要的基础设施和专业知识， 这些复杂的研究，将由研究中心和研究者根据需要进行定义。 履约地点（组织、城市、州） 马萨诸塞州波士顿塔夫茨大学 PHS 398（04/06修订版）第377页表格第2页

Core I: Translational Science The Translational Science Core was established in 2002. The intent of this core is to facilitate the development and implementation of novel clinical/translational HIV studies by CFAR investigators at Tufts and Brown as well as at international sites. The core responds to the evolution of the CFAR epidemic into an ever more complex syndrome which requires expansion of basic and clinical research to translational studies that are capable of examining the clinical import of basic research and identifying the basic mechanisms for observations made in clinical studies. Funding of the core has permitted the development of interdisciplinary studies that would not otherwise be supported and has recruited excellent new investigators to initiate HIV related research projects. The services provided by this core are diverse and have led to the development of a diverse group of studies. The primary aims of the core are to: 1. Specifically support the investigation of the role of human immunodeficiency virus infection (viral burden, viral type and inflammatory changes induced by the viral infection) on clinical outcomes including development of resistance, and development of metabolic and body shape changes (HIVassociated lipodystrophy). 2. Support translational studies of complications of HIV and its therapies, including tuberculosis, diarrheal disease such as cryptosporidal infection and antiretroviral drug toxicities. 3. Support of translational studies in developing the infrastructure and expertise necessary to conduct these complex studies, to be defined as needed by the site and the investigator. PERFORMANCE SITE(S) (organization, city, state) Tufts University, Boston, MA PHS 398 (Rev. 04/06) Page 377 Form Page 2