Translational Science

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Core I: Translational Science The Translational Science Core was established in 2002. The intent of this core is to facilitate the development and implementation of novel clinical/translational HIV studies by CFAR investigators at Tufts and Brown as well as at international sites. The core responds to the evolution of the CFAR epidemic into an ever more complex syndrome which requires expansion of basic and clinical research to translational studies that are capable of examining the clinical import of basic research and identifying the basic mechanisms for observations made in clinical studies. Funding of the core has permitted the development of interdisciplinary studies that would not otherwise be supported and has recruited excellent new investigators to initiate HIV related research projects. The services provided by this core are diverse and have led to the development of a diverse group of studies. The primary aims of the core are to: 1. Specifically support the investigation of the role of human immunodeficiency virus infection (viral burden, viral type and inflammatory changes induced by the viral infection) on clinical outcomes including development of resistance, and development of metabolic and body shape changes (HIVassociated lipodystrophy). 2. Support translational studies of complications of HIV and its therapies, including tuberculosis, diarrheal disease such as cryptosporidal infection and antiretroviral drug toxicities. 3. Support of translational studies in developing the infrastructure and expertise necessary to conduct these complex studies, to be defined as needed by the site and the investigator. PERFORMANCE SITE(S) (organization, city, state) Tufts University, Boston, MA PHS 398 (Rev. 04/06) Page 377 Form Page 2