Role of Gelatinases in Cartilage Degradation after Load Injury in a Murine Model

明胶酶在小鼠模型负荷损伤后软骨降解中的作用

• 批准号: 7509016
• 负责人: CHIH S CHEN
• 金额: $ 8.46万
• 依托单位: HOSPITAL FOR SPECIAL SURGERY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7509016
• 关键词: Accidents; Acute; Affect; Age; American; Animal Model; Apoptosis; Cartilage; Cell Death; Cells; Centers for Disease Control and Prevention (U.S.); Chemistry; Cleaved cell; Collaborations; Collagen; Collagen Type II; Core Protein; Data; Degenerative polyarthritis; Elevation; Enzymes; Epiphysial cartilage; Event; Feasibility Studies; Fibroblasts; Fourier Transform; Future; Gelatin; Gelatinase A; Gelatinase B; Gelatinases; Genes; Histology; Image; Immunohistochemistry; In Situ; Inflammation; Inflammatory; Inflammatory Response; Injury; Interleukin-1; Interleukin-6; Interstitial Collagenase; Joints; Liquid substance; Matrix Metalloproteinases; Measurement; Mechanics; Mediating; Microscopy; Modeling; Molecular; Mus; Necrosis; Outcome; Outcome Study; Phenotype; Physiological; Population; Property; Proteins; Proteoglycan; Recombinants; Rheumatoid Arthritis; Role; Signal Pathway; Site; Sports; Stromelysin 1; Synovial Fluid; Synovial Membrane; System; TNF gene; TNF-alpha converting enzyme; Techniques; Testing; Time; Tissue Inhibitor of Metalloproteinase-1; Tissues; Today; Week; X-Ray Computed Tomography; aggrecan; angiogenesis; cell motility; collagenase; collagenase 3; cytokine; day; enzyme activity; human MMP14 protein; in vitro Model; in vivo; interest; kinematics; macrophage; mouse model; neutrophil; soft tissue; therapeutic target