LSI Doctoral Training Centres - The doctoral training centre in chemical biology
LSI 博士培训中心 - 化学生物学博士培训中心
基本信息
- 批准号:EP/F500416/1
- 负责人:
- 金额:$ 605.59万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Training Grant
- 财政年份:2008
- 资助国家:英国
- 起止时间:2008 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The DTC's research will focus on the understanding of protein-protein and lipid-protein interaction.Quantitative measurement and modelling, of these macromolecular interactions, and the synthesis of new molecules with the ability to disrupt them will open up entirely novel avenues to attack diseases and ultimately be of clinical benefit.The Chemical Biology DTC is designed to exploit the UK's strong position in genomics by providing a bridge into new molecular post-genomic tools and technologies developed by DTC PhD researchers who work at the physical sciences/life sciences interface. The students are both the means by which the tools and technology are developed and the bridge that brings the quantitative perspectives of physical sciences to important biological problems. The need for such researchers has been highlighted by RCUK (http://w,Avw.rcuk.ac.uk/aboutreuk/executivegroup/egmeetings/feb07/070221report.htm) and thepharmaceutical sector (e.g. http://pubs.acs.org/cen/employment/84/8416chemicalbiology.html).Our particular focus on protein-protein and lipid-protein interactions has been chosen following consultation with senior research strategists from the pharmaceutical sector, who recognise that learning how to interfere with these interactions would form the basis for new pharmaceutical approaches to disease. However, they also recognise that such approaches will need to grow within academia and will require multidisciplinary researchers to carry these ideas with them and into industry. Their support of this proposal is a reflection of these longer term intentions.
DTC的研究将集中在蛋白质-蛋白质和脂质-蛋白质相互作用的理解。定量测量和建模,这些大分子相互作用,而具有破坏能力的新分子的合成将开辟全新的途径来攻击疾病,并最终获得临床效益。化学生物学DTC旨在通过提供一个桥梁,分子后基因组工具和技术由从事物理科学/生命科学接口工作的DTC博士研究人员开发。学生既是开发工具和技术的手段,也是将物理科学的定量观点带到重要生物学问题的桥梁。RCUK(http://w,Avw.rcuk.ac.uk/aboutreuk/executivegroup/egmeetings/feb07/070221report.htm)和制药部门(例如http://pubs.acs.org/cen/employment/84/8416chemicalbiology.html)强调了对此类研究人员的需求。我们特别关注蛋白质-蛋白质和脂质-蛋白质相互作用是在与制药部门的高级研究战略家协商后选择的,他们认识到学习如何干扰这些相互作用将形成新的药物治疗疾病方法的基础。然而,他们也认识到,这种方法需要在学术界发展,并需要多学科研究人员将这些想法带入工业界。他们对这项建议的支持反映了这些较长期的意图。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Richard Templer其他文献
Novel Probes for Sensing Lateral Stress in Membranes
- DOI:
10.1016/j.bpj.2009.12.4268 - 发表时间:
2010-01-01 - 期刊:
- 影响因子:
- 作者:
Natalia Goehring;Anca Margineanu;Richard Templer;Oscar Ces - 通讯作者:
Oscar Ces
Richard Templer的其他文献
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{{ truncateString('Richard Templer', 18)}}的其他基金
Lipid control of membrane protein folding
膜蛋白折叠的脂质控制
- 批准号:
BB/F013167/1 - 财政年份:2008
- 资助金额:
$ 605.59万 - 项目类别:
Research Grant
LSI Doctoral Training Centres: Imperial College London
LSI 博士培训中心:伦敦帝国理工学院
- 批准号:
EP/F500076/1 - 财政年份:2007
- 资助金额:
$ 605.59万 - 项目类别:
Training Grant
Doctoral Training Centre - Imperial College London
博士培训中心 - 伦敦帝国理工学院
- 批准号:
EP/E50163X/1 - 财政年份:2006
- 资助金额:
$ 605.59万 - 项目类别:
Training Grant
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