LSI DTCs 2007-Doctoral Training Centre for Regenerative Medicine

国家健康状况的持续改善取决于可负担得起的替代人体组织和相关疗法的有效发展;自愿器官捐献者的严重短缺和传统疗法的缺点导致每年许多患者可预防的死亡。下一次医疗革命将应用再生医学，创造生物疗法或替代品，以替代或恢复因失败或疾病而失去的组织功能。然而，虽然科学已经揭示了这种疗法的潜力，早期产品已经显示出这种疗法的力量，但现在需要长期提供经过适当培训的人员，以应对工程和生命科学的挑战，然后才能实现人类医疗保健的预期效益。由于这一技术产生的产品与主流制药公司生产的产品大不相同，现有的培训方案装备不足，无法满足对越来越多受过适当培训的人员的需求。我们估计，具有必要技能的工程师人数很少，能够与最先进的生物科学家和临床医生“在同一水平上”互动，全国可能不超过100人;在这样一个小社区，50名新培养的博士将产生非常大的影响。在这里，我们提出了一个新的基于英国的DTC在再生医学集成在三所大学具有高度互补的专业知识，学生将在生命科学/工程接口工作所需的核心技能进行培训，然后从事旨在解决该领域的主要挑战的战略研究计划。这将确保为英国开发必要的人才和技术，以在这个快速增长的全球市场中领先。

SummaryContinued improvement in the nation's health depends upon the efficient development of affordable replacement human tissue and related therapies; an acute shortage of willing organ donors and the shortcomings of conventional therapies leads to the preventable death of many patients each year. The next healthcare revolution will apply regenerative medicines, creating biological therapies or substitutes for the replacement or restoration of tissue function lost through failure or disease. However, whilst science has revealed the potential, and early products have shown the power of such therapies, there is now a need for the long term supply of people properly trained with the necessary skills to face the engineering and life science challenges before the predicted benefits in human healthcare can be realised. Because the products arising from this technology differ significantly from those made by mainstream pharmaceutical companies, training programmes currently available are poorly equipped to meet the demand for increasing numbers of appropriately trained personnel. We estimate that the number of engineers with the necessary skills to interact `on the same level' with cutting edge bioscientists and clinicians is very small, perhaps no more than 100 nationally; in such a small community 50 newly trained PhD's will have a very large impact. Here we propose a new UK based DTC in Regenerative Medicine integrated across three Universities with highly complementary expertise where students will be trained in the core skills needed to work at the life science/engineering interface and then engaged in strategic research programmes designed to address the major challenges in the field. This will ensure that the necessary people and enabling technologies are developed for the UK to lead in this rapidly growing worldwide marketplace.