Using Message Framing to Promote HPV Vaccination

使用消息框架促进 HPV 疫苗接种

• 批准号: 7616276
• 负责人: Mary A Gerend
• 金额: $ 7.26万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-17 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7616276
• 关键词: 12 year old; Advisory Committees; Affective; Age; Anogenital venereal warts; Behavior; Behavior Therapy; Caring; Child; Clinical Trials; Cognitive; Condition; Development; Effectiveness; Effectiveness of Interventions; Exposure to; Female; Fostering; Gardasil; Genital Human Papilloma Virus Infection; Goals; HPV-High Risk; Health; Health Communication; Health behavior; Health behavior change; Human; Human Papilloma Virus Vaccine; Human Papillomavirus; Human papilloma virus infection; Immunization; Incidence; Infection; Intervention; Left; Malignant neoplasm of cervix uteri; Mediating; Mediator of activation protein; Medical; Methods; Morbidity - disease rate; Pap smear; Papillomavirus; Parents; Participant; Perception; Population; Prevention; Public Health; Purpose; Randomized; Range; Rate; Relative (related person); Research; Sampling; Scientist; Screening for cancer; Self Efficacy; Sexually Transmitted Diseases; Standards of Weights and Measures; Telephone; Testing; Translating; United States; United States Food and Drug Administration; Vaccinated; Vaccination; Vaccines; Woman; base; behavior change; burden of illness; communication theory; cost; design; follow-up; girls; improved; insight; interest; mortality; pediatrician; preadolescence; prophylactic; psychologic; research study; theories; therapy design; university student; uptake; young adult

DESCRIPTION (provided by applicant): Persistent infection with a sexually transmitted infection known as human papillomavirus (HPV) is the primary cause of cervical cancer. Although Pap testing has significantly reduced the incidence of cervical cancer in the U.S., nearly 4,000 women died of cervical cancer in 2007. A prophylactic quadrivalent HPV vaccine (Gardasil) was recently approved for girls and women ages 9-26. The vaccine protects against infection by four HPV types responsible for over 90% of all genital warts and 70% of all cervical cancers. Routine HPV vaccination is recommended in girls ages 11-12 and "catch-up" vaccination among girls/women ages 13-26 who have not been vaccinated previously. Studies conducted before Gardasil's release found that young women expressed keen interest in the vaccine. Whether high acceptability will translate into high rates of vaccination, however, is unclear. In addition, little is known about effective methods for promoting HPV vaccination in young adults. The proposed research therefore will evaluate a behavioral intervention aimed at promoting catch-up vaccination among female college students, a population that is at high risk for HPV infection. The proposed intervention will apply the use of message framing, a theoretically grounded health communication strategy that involves motivating health behavior change through presentation of equivalent appeals framed in terms of either gains or losses. Message framing has proven to be a highly effective strategy for promoting behavior change across a wide range of health practices, including cancer screening and prevention behaviors. The first aim of the proposed randomized controlled experiment is to assess the effectiveness of a loss-framed intervention (relative to a gain-framed intervention and standard-of-care control) in promoting catch-up HPV vaccination. At baseline, participants will be randomly assigned to one of three interventions (loss, gain, control). Follow-up assessments will be conducted by telephone 2 and 8 months later to assess HPV vaccination status. Based on theory and previous research, exposure to a loss-framed intervention is hypothesized to increase HPV vaccination rates relative to the other two conditions. The second aim is to identify mediators of the intervention effect. Although several studies have attempted to uncover the cognitive and affective mechanisms underlying the effects of framed health messages on behavior, relatively few have been successful. In the proposed research, observed framing effects are expected to be mediated by increases in both perceived vulnerability to HPV infection and self-efficacy to receive the HPV vaccine. HPV infection represents a tremendous threat to public health. It is responsible for increasing medical costs, as well as the psychological and disease burden associated with abnormal Pap testing, genital warts, and cervical cancer. The long-term objectives of the proposed research are to facilitate the development of theory-based health communication interventions for promoting HPV vaccination and, ultimately, to reduce the incidence of cervical cancer.

描述（由申请人提供）：持续感染性传播感染，称为人乳头瘤病毒（HPV）是宫颈癌的主要原因。虽然巴氏试验在美国大大降低了宫颈癌的发病率，2007年，近4 000名妇女死于宫颈癌。一种预防性四价HPV疫苗（Gardasil）最近被批准用于9-26岁的女孩和妇女。该疫苗可预防四种HPV类型的感染，这四种HPV类型导致90%以上的生殖器疣和70%的宫颈癌。建议11-12岁的女孩进行常规HPV疫苗接种，13-26岁以前未接种过疫苗的女孩/妇女进行“追赶”疫苗接种。在Gardasil发布之前进行的研究发现，年轻女性对疫苗表现出浓厚的兴趣。然而，高可接受性是否会转化为高疫苗接种率尚不清楚。此外，对促进年轻人接种HPV疫苗的有效方法知之甚少。因此，拟议的研究将评估一种行为干预措施，旨在促进女大学生的追赶疫苗接种，这是一个HPV感染高风险的人群。拟议的干预措施将应用信息框架的使用，这是一种有理论基础的健康传播策略，涉及通过提出以收益或损失为框架的等效呼吁来激励健康行为改变。事实证明，信息框架是一种非常有效的策略，可以在广泛的健康实践中促进行为改变，包括癌症筛查和预防行为。拟议的随机对照实验的第一个目的是评估损失框架干预（相对于获得框架干预和标准护理对照）在促进追赶HPV疫苗接种方面的有效性。在基线时，参与者将被随机分配到三种干预措施之一（损失，增益，控制）。将在2个月和8个月后通过电话进行随访评估，以评估HPV疫苗接种状态。根据理论和以前的研究，假设暴露于损失框架干预可以相对于其他两种情况增加HPV疫苗接种率。第二个目的是确定中介的干预效果。尽管有几项研究试图揭示框架健康信息对行为影响的认知和情感机制，但相对而言，成功的研究很少。在拟议的研究中，观察到的框架效应预计将通过增加对HPV感染的易感性和接受HPV疫苗的自我效能来介导。HPV感染是对公共卫生的巨大威胁。它负责增加医疗费用，以及与异常巴氏试验，生殖器疣和宫颈癌相关的心理和疾病负担。拟议研究的长期目标是促进发展基于理论的健康传播干预措施，以促进HPV疫苗接种，并最终降低宫颈癌的发病率。